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Application of reagent for detecting gene expression level and construction method of NAC (neoadjuvant chemotherapy) curative effect prediction model for breast cancer patients

A technology of gene expression level and detection method, applied in breast cancer-related fields, can solve problems such as the promotion and application of neoadjuvant chemotherapy that affects the benefit of patients

Active Publication Date: 2019-03-08
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

[0004] At present, the indications, specific chemotherapy regimens, chemotherapy schedules, and efficacy evaluation of neoadjuvant chemotherapy have not yet been completed, which affects the benefits of patients and the promotion and application of neoadjuvant chemotherapy to a certain extent.

Method used

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  • Application of reagent for detecting gene expression level and construction method of NAC (neoadjuvant chemotherapy) curative effect prediction model for breast cancer patients
  • Application of reagent for detecting gene expression level and construction method of NAC (neoadjuvant chemotherapy) curative effect prediction model for breast cancer patients
  • Application of reagent for detecting gene expression level and construction method of NAC (neoadjuvant chemotherapy) curative effect prediction model for breast cancer patients

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Embodiment 1

[0080] The present embodiment provides a method for constructing a NAC curative effect prediction model for breast cancer patients, which includes the following steps:

[0081] Patient and Model

[0082]This study was approved by the Institutional Ethics Committee of West China Hospital (IRS number: 2017-476), and the clinical trial has been registered in the China Clinical Trial Registry (http: / / www.chictr.org.cn / ; Registration number: ChiCTR1800016763). The inventors retrospectively collected clinicopathological data of patients who underwent curative surgery and NAC treatment from January 2013 to December 2017. It should be noted that NAC treatment refers to a treatment plan of 4 or 6 cycles of anthracyclines combined with taxanes.

[0083] The NAC regimen includes a TEC regimen (every three weeks: docetaxel 75mg / m 2 , Epirubicin 50mg / m 2 and cyclophosphamide 500 mg / m 2 ) and PE regimen (weekly: paclitaxel 120mg / m 2 And epirubicin 50mg / m 2 , every 3 weeks as a course ...

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Abstract

The invention discloses an application of a reagent for detecting gene expression level and a construction method of an NAC (neoadjuvant chemotherapy) curative effect prediction model for breast cancer patients, and relates to the technical field of breast cancer. Particularly, the prediction model can predict the curative effect of anthracyclines and taxus drugs in NAC, so as to provide a basis for whether the breast cancer patients accept NAC regimens or choose which type of NAC regimens. The patients who are sensitive to chemotherapy regimens and may reach pCR can seize the opportunity of NAC by predicting the curative effect, so that effective NAC is conducted, and the breast-conserving rate or survival rate is increased; however, the patients who are insensitive to chemotherapy regimens or may cause tumor progression can choose other effective treatments in time.

Description

technical field [0001] The invention relates to the technical field related to breast cancer, in particular to the application of reagents for detecting gene expression levels and the construction method of NAC curative effect prediction model for breast cancer patients. Background technique [0002] With the continuous improvement of diagnosis and treatment concepts and the rapid development of science and technology, the treatment effect of breast cancer has been significantly improved, but it is one of the most common malignant tumors in women. Today, the treatment of breast cancer is centered on radical surgery, combined with radiotherapy, chemotherapy and targeted therapy. Neoadjuvant chemotherapy (NAC) has been widely used in clinical practice. [0003] In addition to targeting patients with locally advanced breast cancer, NAC can also detect the sensitivity of chemotherapy regimens and strive for breast-conservation opportunities for downstaging, etc. Related studie...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/106C12Q2600/158C12Q2600/166
Inventor 叶丰步宏郑鸿付波杨李波邓玲
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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