Hydrogenation calalyst of N-(3,4-dimethyl phenyl amine)-D-riboside

Abstract

A hydrocatalyst for preparing N-(D)-deoxyriboseol-3,4-dimethylaniline as the intermediate in semi-synthesizing riboflavin is a novel alloy catalyst prepared from Raney Ni-catalyst through modifying by the transition metal elements of families I, II, IV, VI, VII and VIII chosen from Cu, Zn, Ti, Zr, Cr, Mo, Mn, Fe, Co, Ru, Rh, Pd and Pt. It contains Ni, Al and transition metal element in Wt. ratio of 1000:1000:(1-280). Its advantages are high activity, selectivity and output rate, low dosage and low cost.

Description

Technical field [0001] The present invention relates to riboflavin (vitamin B 2 ) semi-synthetic process to prepare the hydrogenation catalyst of the important raw material intermediate N-(D)-deoxyribitol-3,4-xylaniline (hereinafter referred to as ribosamine), specifically it is a modified Raney nickel catalyst. Background technique [0002] In addition to being used as a medicine, riboflavin is also widely used as a feed additive and food additive. It was produced by microbial fermentation in the early days. In recent years, the process of producing riboflavin by chemical semi-synthesis has been developed. The riboflavin semi-synthesis process uses glucose as the starting material, fermented in the presence of shikimic acid auxotrophic mutant strains to obtain D-ribose, and then undergoes steps such as impurity removal, hydrogenation, coupling, cyclization, and purification to obtain riboflavin white. [0003] D-ribose first reacts with 3,4-xylidine to generate N-(3,4-xyl...

AI Technical Summary

Problems solved by technology

[0004] Existing patents, such as CN, 1122833A, 1194262A, etc., when N-(3,4-xylaniline)-D-riboside hydrogenation produces ribosamine, use Raney nickel as a catalyst, but there are low catalyst activity, Problems such as large dosage, low yield, and high cost; in CN1194252A, a large amount of sodium sulfate is also required, resulting in the disadvantages of low purity and poor quality of the target product ribosamine; and none of the above-mentioned patents analyzes the purity of the target product ribosamine, What is disclosed is only the yield of ribosamine crude product, especially the yield introduced in CN1194252A2 is far from the actual yield (or pure yield) of ribosamine, which is much higher