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Medicine releasing control method for implanting type medical equipment

An implantable medical and control method technology, which is applied in the field of drug release control by organic/inorganic composite coatings, can solve the problems of toxic monomer or cross-linking agent residue, unsatisfactory long-term release, drug inactivation, etc., and achieve high Elasticity, high toughness, and the effect of improving adhesion

Inactive Publication Date: 2003-01-22
LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, so far, there is no polymer coating material that has all the above advantages at the same time. For example, materials with better biocompatibility are often hydrophilic, and will swell to a greater extent in the blood, so that the The encapsulated drug is released quickly, which cannot meet the requirement of long-term release; the chemical cross-linking of materials often produces residues of toxic monomers or cross-linking agents, and physical cross-linking often requires elevated temperatures, which can easily inactivate the drug; The degradation products of degraded polymer materials are likely to cause local inflammatory reactions, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] In a 1000 ml three-neck flask equipped with a mechanical stirrer and a reflux condenser, add 100 ml methyl methacrylate, 50 ml butyl methacrylate, 50 ml hydroxypropyl methacrylate, and 25 ml trimethoxysilane Propyl methacrylate was dissolved in 400 milliliters of anhydrous methanol, and the temperature was raised to 70° C. under nitrogen protection, and 20 milliliters of anhydrous methanol dissolved with 0.5 gram of azobisisobutylcyanide was added, and refluxed for 8 hours under stirring. After cooling, the obtained viscous solution was poured into 2000 milliliters of petroleum ether to precipitate, washed and vacuum-dried to obtain 201 grams of solid polymer.

[0028] Add 10 grams of tetraethyl orthosilicate (TEOS), 5 milliliters of 0.1 mol / l hydrochloric acid solution to 20 milliliters of ethanol, stir and hydrolyze at 60 ° C for 5 hours, add 10 grams of the synthesized polymer and another 30 milliliters of ethanol , after continuing to stir for 1 hour, cool to room t...

Embodiment 2

[0033] Add 5 grams of tetraethyl orthosilicate, 5 grams of tetraethyl titanate, and 6 ml of 0.1 mol / l hydrochloric acid solution into 20 ml of isopropanol, stir and hydrolyze at 60°C for 6 hours, and obtain viscous transparent Sol.

[0034] Add 2 grams of tobacol to the above solution and stir until completely dissolved, then place the obtained transparent sol at room temperature for 10 days to gel, and then dry at 60° C. for 5 hours to obtain a drug-containing xerogel. The xerogel was pulverized and sieved in a ball mill to obtain 4 grams of particles with a diameter of 5 microns or less.

[0035] Carry out the synthesis of polymer with the device identical with example 1, difference is that the raw material of polymerization changes 180 milliliters of butyl methacrylates into, 30 milliliters of hydroxyethyl methacrylates and 30 milliliters of vinyl acetates, all the other conditions are identical, reaction At the end, 195 grams of polymer were obtained after purification. ...

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Abstract

The present invention provides a method of preparing inorganic and organic composite coating to control medicine release on the surface of implanted medical equipment. The inorganic material is silicon sol or titanium sol and the organic material is polymer with excellent biocompatibility and filming performance. The present invention combines the excellent performance of inorganic material and polymer and is superior to available inorganic and organic coating and is suitable for long-period controlled release of medicine sensitive to outer heat, light and other conditions.

Description

field of invention [0001] The invention belongs to the technical field of medical devices, in particular to a method for controlling drug release applied to implantable medical devices, in particular to a method for controlling drug release by using an organic / inorganic composite coating. Background technique [0002] In the current surgical operation or interventional treatment methods, it is often necessary to implant some special medical devices in the patient's body for treatment, such as heart valves, valve rings, stents in blood vessels and digestive tracts, and the like. These implantable medical devices made of metal or polymer materials are being used to treat more and more diseases. However, these implants may also cause the following side effects in the human body, including: increasing the possibility of postoperative infection; triggering foreign body reactions, causing inflammation or local fibrosis; triggering wound healing reactions to cause local tissue hype...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61M31/00
Inventor 钟伟杜强国王海涛杨玉良
Owner LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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