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Porous scaffold with complex contour and its preparing process

A porous scaffold and shape technology, applied in the fields of polymer materials and biomedical engineering, can solve the problems of unfavorable cell implantation and ingrowth of nutrients and metabolites, solvent volatilization and difficulty in demoulding, and achieve good shape retention ability, Ease of preparation

Inactive Publication Date: 2002-10-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the solvent casting method, the existence of a large amount of solvent makes the polymer, porogen, and solvent complex have good fluidity, so it can be cast and formed to prepare a porous scaffold with a simple shape and a thickness of no more than 2 mm, but the shape is complex. , thicker porous scaffolds, due to solvent volatilization and difficulty in demolding, there is no report in the literature that solvent casting method is used to prepare scaffolds with complex shapes
On the other hand, the solvent casting method often leads to the formation of a surface cortex when preparing porous scaffolds, which is detrimental to the transport of nutrients and metabolites, as well as the implantation and ingrowth of cells in tissue engineering applications.

Method used

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  • Porous scaffold with complex contour and its preparing process
  • Porous scaffold with complex contour and its preparing process
  • Porous scaffold with complex contour and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1, first make a human ear model with gypsum, put it into a copper mold box, and pad the bottom flat; mix the silicone rubber main agent and curing agent with a ratio of 10 grams: 0.68 grams, then fill it into the mold box, press In practice, solidify at room temperature for 5 minutes, demoulding to obtain flexible mold A (female mold A); put female mold A into the mold box, then put it into the human ear model, repeat the above process to obtain female mold B (see figure 1 ); Simultaneously, design and process copper rigid mould, make flexible mold just can be put into rigid mould; 0.3 gram viscosity-average molecular weight is 55000 PCL is dissolved in the chloroform concentrated solution that forms PCL in 2 gram chloroforms; Sieve the porogen particles, add 2.7 grams of sodium chloride particles with a particle size of 280-450 μm into the solution, stir evenly, and wait for the solvent to partially volatilize to form a dough-like polymer / solvent / porogen compoun...

Embodiment 2

[0055] Embodiment 2, model making and flexible-rigid composite mold design and manufacture are the same as embodiment 1. Dissolve 0.21 grams of PCL with a viscosity average molecular weight of 55,000 in 2 grams of chloroform to form a concentrated solution of PCL in chloroform, sieve the sodium chloride porogen particles, and add 2.79 grams of sodium chloride particles with a particle size of 280-450 μm to the solution , stir evenly, and wait until the solvent is partially volatilized to form a dough-like polymer / solvent / porogen compound; put the flexible mold A into the rigid mold, fill in the polymer / solvent / porogen compound, and cover the flexible mold B, press the metal platen again, compact it, fasten it with bolts, and keep it at room temperature for 5 minutes to fully set the shape; demoulding, to obtain a solid support of the polymer / solvent / porogen composite with the desired shape, in the Leave it overnight at room temperature to evaporate the solvent, then remove res...

Embodiment 3

[0056] Embodiment 3, model making and flexible-rigid composite mold design and manufacture are the same as embodiment 1. Dissolve 0.21 grams of PCL with a viscosity average molecular weight of 55,000 in 2 grams of chloroform to form a concentrated solution of PCL in chloroform, sieve the sodium chloride porogen particles, and add 2.79 grams of sodium chloride particles with a particle size of 180-280 μm to the solution , stir evenly, and wait until the solvent is partially volatilized to form a dough-like polymer / solvent / porogen compound; put the flexible mold A into the rigid mold, fill in the polymer / solvent / porogen compound, and cover the flexible mold B, press the metal platen again, compact it, fasten it with bolts, and keep it at room temperature for 5 minutes to fully set the shape; demoulding, to obtain a solid support of the polymer / solvent / porogen composite with the desired shape, in the Leave it overnight at room temperature to evaporate the solvent, then remove res...

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Abstract

A porous scaffold with complex contour similar to the damaged tissue or organ is prepared from the biodegradable and biocompatible high-molecular material through designing the both flexible and rigid composite mould and the solvent-based cold press / particle infusion. Its advantages are simple and feasible preparing process and high porosity (more than 90%).

Description

technical field [0001] The invention belongs to the technical field of polymer materials and the field of biomedical engineering, and specifically relates to a porous scaffold with complex shape and a preparation method thereof, in particular to a biodegradable porous polymer scaffold for tissue engineering whose shape is similar to a defect tissue or organ and its preparation method. technical background [0002] Porous scaffolds are widely used in chemical, pharmaceutical, biomedical engineering and other technical fields. In recent years, with the rapid development of tissue engineering research, porous scaffolds play an increasingly important role in the development of tissue engineering technology and products. [0003] Tissue engineering is a new method of rebuilding or repairing tissue with living cells. Its basic principle and method are to plant human cells cultured in vitro on tissue engineering porous scaffolds that have good biocompatibility and can be gradually...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/56
Inventor 丁建东吴林波张俊川朱文
Owner FUDAN UNIV
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