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Chinese medicinal composition for chronic primary glomerulonephritis and its preparation and quality control

A technology of glomerulonephritis and composition, applied in the field of traditional Chinese medicine composition for the treatment of chronic primary glomerulonephritis, can solve the problems of poor western medicine, difficult treatment, poor prognosis, etc., achieve no side effects, reduce blood Creatinine, the effect of improving clinical symptoms

Inactive Publication Date: 2006-07-19
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are varying degrees of proteinuria in urine routine examination, and red blood cells can often be seen in urine sediment microscopy. Most patients have varying degrees of hypertension and renal dysfunction, which is difficult to treat and has a poor prognosis. Its onset is latent, and its clinical manifestations can be Mild to severe or sometimes mild and sometimes severe, but in general, it gradually develops to renal failure without stopping, which is life-threatening
[0003] At present, there is no good way for western medicine to treat chronic primary glomerulonephritis. Traditional Chinese medicine has its unique effect in the treatment of chronic primary glomerulonephritis. At present, there is no treatment for chronic primary glomerulonephritis in the market. Glomerulonephritis is a Chinese patent medicine with kidney deficiency and damp-heat syndrome. Therefore, clinicians, patients, and market supply and marketing need to develop Chinese patent medicines that are effective and have no side effects in the treatment of chronic primary glomerulonephritis with kidney deficiency and damp-heat syndrome.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental Example 1 Effect of this composition tablet (SYL-11) on rat membranous nephropathy caused by cationized bovine serum albumin (C-BSA)

[0032] 1.1 Model making

[0033] Referring to Border et al. [1、2、3] Methods The rat model of membranous nephropathy was established with C-BSA. According to the Border method, the bovine serum albumin was treated with carbodiimide to make cationized bovine serum albumin (C-BSA), and the isoelectric point (PI) = 10 was measured after freeze-drying, and stored in -80 ~ C refrigerator in spare. 60 male healthy Wistar rats were taken and fed for one week, 10 were randomly selected as the normal control group, and the remaining 50 were modeled. For pre-immunization, 1.1 mg C-BSA was dissolved in 0.55 ml normal saline, fully emulsified with an equal amount of incomplete Freund's adjuvant, and each model rat was injected subcutaneously at multiple points. After the pre-immunization, the 50 modeled rats were weighed and randomly...

experiment example 2

[0087] Experimental Example 2 Effect of this composition tablet (SYL-11) on minimal change nephropathy in rats caused by purinomycin

[0088] 1.1 Model making

[0089] Sixty male Wistar rats were adaptively fed for one week after repurchase, and were randomly divided into 6 groups according to body weight, with 10 rats in each group, one of which was taken as the normal control group, and the remaining 50 rats were used for modeling. reference method [5、6] modeling. Inject 1% puromycin 10mg / kg body weight intraperitoneally to the model rats every day for 1 week continuously from the first injection day.

[0090] 1.2 Grouping and dosage

[0091]Normal control group: 10 normal rats, fed with 3ml of distilled water, once a day; model control group: 10 model rats, fed with 3ml of distilled water, once a day; 10 mice, each fed with 3ml of Tripterygium wilfordii polyglycoside tablet suspension with a concentration of 0.37mg / ml, once a day, the daily dosage of 0.0055g / kg is equiv...

Embodiment 1

[0136] Example 1: Astragalus 1676g Tripterygium wilfordii 1676g Cornus officinalis 419g

[0137] Jue bed 2514g licorice 419g

[0138] Take tripterygium wilfordii, acanthus, and Cornus officinalis, soak in 80% ethanol for 2 hours, then heat and reflux to extract three times, the amount of ethanol is 8 times, 5 times and 5 times respectively, each time for 1 hour, combine the ethanol extracts, filter The ethanol was recovered from the filtrate, concentrated at 80°C to a thick extract with a relative density ρ of 1.30; astragalus and licorice were added with 8 times the amount of water, decocted twice for 1.5 hours each time, the decoctions were combined, filtered, and the filtrate was concentrated to an appropriate amount , where each milliliter is equivalent to 2g of the original medicinal material, centrifuged to obtain a centrifuge, and when the centrifuge is concentrated to a relative density ρ of 1.30 at 80°C, add thick extracts of tripterygium wilfordii and other ...

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PUM

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Abstract

A Chinese medicine for treating chronic or primary glomerular nephritis is prepared from 5 Chinese-medicinal materials including astragalus root, Tripterygium wilfordii, dogwood fruit, liquorice root, etc through decocting and / or extracting in alcohol. Its quality control method is also disclosed. Its advantages are high curative effect and no toxic by-effect.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic primary glomerulonephritis, and to a preparation method and a quality control method of the composition. Background technique [0002] Chronic glomerulonephritis (chronic nephritis for short, CGN) is a group of diseases that originate in the glomerulus composed of various reasons and various pathological types. The clinical feature is that the course of the disease is long, there may be a period of asymptomatic period, and the course of the disease is slowly progressive. There are varying degrees of proteinuria in urine routine examination, and red blood cells are often seen in urine sediment microscopic examination. Most patients have varying degrees of hypertension and renal function damage. It is difficult to treat and the prognosis is poor. Its onset is latent, and its clinical manifestations can b...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K125/00A61K131/00A61K36/481A61K36/40A61K36/37A61K127/00A61K133/00A61K36/19A61P13/12G01N33/15G01N27/02
Inventor 王刚肖伟戴翔翎凌娅孙志男刘涛黄冰峰
Owner JIANGSU KANION PHARMA CO LTD
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