Isulin solid granular, its preparation method and its use in preparing medicine for treating diabetes

Abstract

The invention discloses an insulin solid particle, a preparation method thereof and an application of the solid particle in preparing a medicine for treating diabetes, which belongs to a pharmaceutical preparation containing insulin. Insulin, stabilizers, biodegradable polymers and intestinal mucosal absorption promoters are used as raw materials to prepare solid particles with a particle size of 0.2-50 microns in a double-layer composite structure, filled in enteric-coated capsules, or wrapped in enteric-coated films The oral insulin enteric-coated capsule preparation or oral insulin enteric-coated tablet preparation for the treatment of diabetes made in this way can be taken orally 1-3 times a day, which can replace the injection of insulin preparations and achieve the same hypoglycemic effect. The insulin enteric-coated capsule or enteric-coated tablet prepared by the method has the characteristics of convenient administration, long-lasting drug effect and high bioavailability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing insulin, in particular to an insulin solid particle, a preparation method thereof and an application of the solid particle in preparing a drug for treating diabetes. Background technique [0002] At present, insulin is still administered by injection in the treatment of diabetes. For diabetics who need long-term medication, injection will bring pain and inconvenience to the patient. In order to overcome these disadvantages, efforts have been made to develop oral insulin. Because insulin is easily digested and destroyed in the gastrointestinal tract, it is difficult for it to enter the body through the intestinal tract to exert its hypoglycemic effect. Protease inhibitors can reduce the destruction of insulin, thereby significantly increasing the absorption of insulin in the intestine. But protease inhibitors also inhibit the body's digestion and absorption of protein. [0003] US Pate...

AI Technical Summary

Problems solved by technology

[0008] The present invention aims to solve the problem that insulin is easily digested and destroyed in the gastrointestinal tract, so it is difficult to enter the body through the intestinal tract to exert a hypoglycemic effect, and provides a solid insulin particle and a preparation method thereof and the use of the solid particle in preparing and treating diabetes drug application

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