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Prepn process of combined delayed releasing agent for preventing and treating animal's tinea pedis and mite disease

A technology of dermatophytes and sustained-release agents, which is applied in the field of preparation of animal skin disease prevention and treatment agents, can solve the problems of easy crystallization and precipitation of drugs, low drug inclusion rate, and unstable product effects, and achieve good control effects

Inactive Publication Date: 2005-07-13
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing the joint sustained-release agent, the difficulties encountered are the low drug inclusion rate, only about 60%, the drug is easy to crystallize and the product is unstable in the application test.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The combined sustained-release agent for preventing and treating animal dermatophytosis and acariasis is prepared according to the following process steps and process conditions:

[0017] (1) 1,000 grams of powdery fungicide griseofulvin + 3,000 milliliters of solvent dimethyl sulfoxide → heating in a water bath (50° C.) until the drug is completely dissolved into a transparent liquid;

[0018] (2) Grind 1000 grams of powdered β-cyclodextrin + 600 milliliters of distilled water for 20 minutes to form a paste;

[0019] (3) Pour the griseofulvin solution into the pasty β-cyclodextrin, stir for 40 minutes, and continue inclusion at room temperature for 60 minutes;

[0020] (4) 10 grams of powdered acaricide abamectin + 300 milliliters of ethyl acetate → heating in a water bath (50° C.) until the medicine is completely dissolved into a transparent liquid;

[0021] (5) Pour the avermectin solution into the inclusion complex of griseofulvin and β-cyclodextrin, stir for 40 mi...

Embodiment 2

[0024] (1) Griseofulvin 1000 grams + solvent dimethyl sulfoxide 4500 milliliters → water bath heating (50 ℃), until the drug is completely dissolved into a transparent liquid;

[0025] (2) 1000 grams of β-cyclodextrin + 950 ml of distilled water → grind for 30 minutes to form a paste;

[0026] (3) Pour the griseofulvin solution into the pasty β-cyclodextrin, stir for 80 minutes, and continue inclusion at room temperature for 90 minutes;

[0027] (4) 10 grams of Abamectin + 400 milliliters of solvent acetone → heating in a water bath (50° C.) until the medicine is completely dissolved into a transparent liquid;

[0028] (5) Pour the avermectin solution into the inclusion complex of griseofulvin and β-cyclodextrin, stir for 65 minutes, place at 30-40°C until dry, and grind for 20 seconds, then 80-90 mesh After sieving, it becomes the combined sustained-release powder product;

[0029] (6) with embodiment 1 (6) step

Embodiment 3

[0031] (1) Griseofulvin 1000 g + solvent N, N-dimethylformamide 6000 ml → water bath heating (50 ° C), until the drug is completely dissolved into a transparent liquid;

[0032] (2) Grind 1000 grams of β-cyclodextrin + 1300 ml of distilled water for 40 minutes to form a paste;

[0033] (3) Pour the griseofulvin solution into the pasty β-cyclodextrin, stir for 120 minutes, and then place at room temperature to continue inclusion for 120 minutes.

[0034] (4) Heat 10 g of ivermectin + 500 ml of methanol → water bath (50°C) until the drug is completely dissolved into a transparent liquid;

[0035] (5) Pour the ivermectin solution into the above-mentioned inclusion complex of griseofulvin and β-cyclodextrin, stir for 90 minutes, place at 30-40°C until dry, grind for 20 seconds, and 80-90 mesh After sieving, it becomes the combined sustained-release powder product;

[0036] (6) With the 6th step of embodiment 1.

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PUM

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Abstract

The invention discloses a preparation method of a combined slow-release agent for preventing and treating animal skin ringworm and mite disease, which significantly improves the inclusion rate of the drug in β-cyclodextrin, thereby successfully preparing an efficient and stable drug for preventing and treating animal skin diseases. new drug dosage forms. The main point of its technical plan is to use griseofulvin and abamectin or ivermectin and beta cyclodextrin as main raw materials, carry out reasonable optimization ratio and supplement with certain process conditions, first griseofulvin Dissolve in a solvent, grind the β-cyclodextrin with distilled water to form a paste, mix the two together for a period of time, then add the abamectin solution or ivermectin solution dissolved in a solvent, stir, mix and include After being dried and pulverized, it can be prepared as joint sustained-release powder or formulated as joint sustained-release injection, and then packaged. It is mainly used in the prevention and treatment of psoriasis and mites in rabbits, pigs, sheep, dogs, cats, cattle and other animals.

Description

technical field [0001] The invention relates to a preparation method of an agent for preventing and treating animal skin diseases, in particular to a preparation method of a combined slow-release agent for preventing and treating animal dermatophytosis and acariasis. Background technique [0002] Dermatophytosis and acariasis are common skin diseases of animals. They are characterized by skin itching, hair loss, crusting and abnormal skin changes. Moreover, the clinical symptoms of these two diseases are similar, and it is generally difficult to distinguish them, and often mixed infections. Therefore, griseofulvin and ivermectin or avermectin are usually used in production to prevent and treat these two diseases. However, griseofulvin can only kill mycelium, but is ineffective against bacteria; while ivermectin or abamectin can only kill mites, but is ineffective against mite eggs, so it must be taken for several days in a row Or just can reach therapeuti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/14A61K9/10A61P33/14A61P31/10A61P17/00
Inventor 张雪娟孙仁寅冯尚连袁国华方兰勇程菊芬李国勤卢明文徐海风
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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