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Gel type floxacin eye ointment

An ofloxacin and gel-type technology, applied in the field of decoro eye ointment, can solve the problems of difficulty in passing oral drugs through the blood-eye barrier, eye drops are easily diluted by tears, and the residence time is short, so as to avoid other side effects, Avoid gastrointestinal irritation, long stay effect

Inactive Publication Date: 2004-12-22
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the large dosage and the difficulty of oral medicine passing through the blood-ocular barrier, an ophthalmic gel was invented for topical administration in ophthalmology. Small amount, improve the bioavailability of the active ingredients of the drug, increase the curative effect and drug safety

Method used

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  • Gel type floxacin eye ointment
  • Gel type floxacin eye ointment

Examples

Experimental program
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Effect test

Embodiment Construction

[0009] Prescription 1:

[0010] Ofloxacin……………0.3g Carbomer……………0.6g

[0011] Sodium chloride………………0.5g Boric acid………………1.0g

[0012] Hydrogenated castor oil……1.0g Ethylparaben………0.025g

[0013] Propylene glycol………………1.0g Sodium hyaluronate………0.05g

[0014] Prepared………………………… 100.0g

[0015] Operation process:

[0016] ①. Grind ofloxacin finely, stir together with sodium chloride, hydrogenated castor oil, ethyl paraben, and propylene glycol, add water, and heat to dissolve them all.

[0017] ②. Boric acid, carbomer, stir evenly, add to ①.

[0018] ③.Heat and stir evenly.

[0019] ④. Cool down, below 40 ℃, add sodium hyaluronate.

[0020] ⑤. Filtration, packaging, packaging, that is.

[0021] Prescription 2:

[0022] Ofloxacin………………0.1-1.0g Carbomer……………0.1-3.0g

[0023] Sodium chloride…………………0.1-1.0g Boric acid……………0.5-2.0g

[0024] Hydrogenated castor oil………0.1-5.0g Ethylparaben………0.025-0.1g

[0025] Propylene glycol………………0.5-5.0g Sodium hyaluronate………0.01-0.1g

...

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Abstract

The present invention relates to a gel eye ointment (Dicklor eye ointment) prepared by using ofloxacin as medicinal effective component. Its main composition comprises ofloxacin, cardralazine, boric acid, hydrogenated hardened castor oil, ethylparaben, propanediol and sodium hyaluronate, said materials can be made into the stable water-soluble transparent emulsion ointment body, after it is used, a layer of air-permeable reticular membrane is formed on the surface of eye, its effect is durable, mainly can be used for curing bacterial conjunctivitis due to sensitive bacteria, also can be used for curing the ophthalmopathies of blepharitis, hordeolum, dacryocystitis and tarsadenitis, etc.

Description

technical field [0001] The invention relates to an active ingredient of a medicine—ofloxacin—made into a gel-type ophthalmic ointment for the first time, which is applied to the treatment of bacterial infection in ophthalmology, and the trade name is Dikeluo eye ointment. Background technique [0002] Currently reported ophthalmic preparations of ofloxacin in production include: 0.3% ofloxacin eye drops and 0.3% ofloxacin ophthalmic ointment, but there is no production of ofloxacin gel ophthalmic ointment. [0003] Dicoro is the approved brand name of ofloxacin ophthalmic ointment. Contents of the invention [0004] In order to overcome the large dosage and the difficulty of oral medicine passing through the blood-ocular barrier, an ophthalmic gel was invented for topical administration in ophthalmology. The amount is small, the bioavailability of the active ingredients of the drug is improved, and the curative effect and drug safety are increased. [0005] The technical...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/5383A61K31/5386A61P27/02A61P31/04
Inventor 刘继东高峨马风明姚东民宋长海刘立新
Owner SHENYANG XINGQI PHARM CO LTD
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