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Absorbable stent

A technology for supporting rods and substrates, used in stents, medical science, coatings, etc., can solve the problems of poor mechanical properties, slow corrosion rate, and difficult absorption of corrosion products, and achieve the effect of short corrosion and absorption cycles

Pending Publication Date: 2022-08-02
BIOTYX MEDICAL (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The corrosion rate of iron-based absorbable stents is slow, and the corrosion products are difficult to absorb, which cannot meet the clinical requirements for the corrosion and absorption cycle of absorbable stents. Although the corrosion and absorption cycle can be shortened by reducing the wall thickness, the diameter of the stent will inevitably be reduced. support strength
For magnesium-based absorbable stents and polymer-based absorbable stents with relatively fast corrosion rates, the mechanical properties of the materials are poor. In order to meet the requirements of early radial support strength, the stent needs to be thicker, but the thickness of the stent will increase. As a result, the stent outline has a large diameter and poor bending performance, which is not conducive to delivery and crossing the lesion, and has all the disadvantages of thick-walled stents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] see also Figures 1 to 3 , an absorbable coronary stent, the base material is nitrided iron, the base includes a plurality of wave circles 01 connected by connecting units 02 and arranged in the axial direction, two adjacent wave circles 01 and connecting units 02 are formed In the closed side branch unit 03, the wave circle 01 is composed of a plurality of waveforms 011 arranged in the circumferential direction.

[0087] The polishing allowance of the preform with the predetermined matrix structure obtained by cutting the nitrided iron tube with an outer diameter of 1.3 mm is 0.025 mm; after the preform is polished to absorb the stent 100, the wall thickness of the support rod B of the stent 100 is 0.038 mm , the rod width is 0.076mm, and the rod width is uniform.

[0088] The ratio of the rod width to the wall thickness of the support rod B is 2.0, the number A of wave circles 01 is 28, the number B of connecting units 02 between adjacent wave circles 01 is 3, and th...

Embodiment 2

[0092] See Figure 7 , the matrix material of the absorbable coronary vascular stent in this embodiment is iron nitride, which has a similar structure to the matrix of the absorbable coronary vascular stent in Example 1. The differences are:

[0093] The polishing allowance of the preform with a predetermined matrix structure obtained by cutting a nitrided iron tube with an outer diameter of 1.6 mm is 0.030 mm; after the preform is polished into an absorbable stent 200, the wall thickness of the support rod of the stent is 0.052 mm, and the wave shape is 0.052 mm. 211 as Figure 7 As shown, the rod width varies between [0.074, 0.091] mm.

[0094] The ratio of the rod width to the wall thickness of the support rod is [1.42, 1.75], the number A of wave circles is 15, the number B of connecting units between adjacent wave circles is 4, and the number C of waves contained in the wave circles is 16. The included angle α0 of the support rod is 41.5°, and the section length L0 of t...

Embodiment 3

[0098] The base material of the absorbable coronary stent in this embodiment is iron nitride, which has a similar structure to the base of the absorbable coronary stent in Embodiment 2. The difference is that the structure of the connecting unit 52 of the stent is as follows: Image 6 As shown in , the wall thickness of the support rods of this stent was reduced to 0.047 mm.

[0099] Implanted in a 3.0mm lumen, the radial support strength of the absorbable coronary stent is 120kPa, which is the same as the radial support strength of the absorbable coronary stent in Example 2, but the absorbable coronary stent has the same radial support strength as the absorbable coronary stent in Example 2. The volume per unit vessel area of ​​the stent was lower at 6.4 μm.

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Abstract

The absorbable stent comprises an absorbable base body, the base body comprises a plurality of wave rings which are connected through connecting units and are arranged in the axial direction, each wave ring is composed of a plurality of waveforms arranged in the circumferential direction, and each waveform is composed of a wave crest, a wave trough and a supporting rod connecting the wave crest and the wave trough. The two adjacent wave rings and the connecting unit form a closed collateral unit, and the volume of the base body per unit blood vessel area is [4, 40] [mu] m. The radial supporting strength of the absorbable stent can meet clinical application, and the volume of a base body per unit blood vessel area is lower than that of an existing stent. When the same material is used, the absorbable stent provided by the invention has shorter corrosion and absorption periods compared with the existing stent.

Description

technical field [0001] The invention relates to the technical field of interventional medical devices, in particular to an absorbable stent. The absorbable matrix of the absorbable stent has a lower volume per unit blood vessel area and better radial support strength. Background technique [0002] Vascular stents can be divided into permanent stents and absorbable stents according to the length of time they remain in the blood vessel. Permanent stents are made of non-degradable materials, such as 316L stainless steel, platinum-chromium alloy, nickel-titanium alloy, cobalt-chromium alloy, tantalum and titanium. Causes problems such as restenosis in the middle and late stages of blood vessels, chronic inflammation, late and very late thrombosis. After the absorbable stent is implanted into the blood vessel, it will gradually degrade and be absorbed by the body until it disappears completely. It is an ideal choice for the treatment of cardiovascular diseases. The absorbable s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90
CPCA61F2210/0004A61F2/90A61F2/915A61F2002/9155A61F2002/91575A61F2002/91541A61F2002/91525A61F2250/0036A61F2250/0018A61F2002/91591A61F2/82
Inventor 付文超
Owner BIOTYX MEDICAL (SHENZHEN) CO LTD
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