Sugammadex sodium for injection and preparation method thereof
A sugammadex sodium injection technology, applied in chemical instruments and methods, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., to achieve large specific surface area, improve purity, and improve adsorption efficiency Effect
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[0044] The preparation of magnetic nanotubes with a surface-activated nanotube layer-magnetic material layer-mesoporous silica layer structure includes the following steps:
[0045] 1) Preparation of nanotube layer: put 1 gram of carbon nanotubes into a 200-mL flask, add 100 mL of ethanol, 50 mL of water, and 6.9 mL of ammonia water (28 wt %) in turn and stir well; then, add 1 mL of ethyl orthosilicate ester, centrifuged after the reaction is completed; washed with a mixed solvent of ethanol and water for several times, centrifuged, and dried at room temperature for 12 hours to obtain a carbon nanotube-dense silica nanotube core-shell structure;
[0046] 2) Preparation of magnetic material layer: adding FeCl to 1) solution 2 and FeCl 3 The mixed solution was sonicated for 50 min, and the solution was filtered off; the filter cake was added to the sodium hydroxide solution, stirred and sonicated, and then reacted at 110-130 °C for 2-3 h, the liquid was removed and dried to for...
Embodiment 1
[0051] A method for preparing sugammadex sodium provided in the embodiment of the present invention comprises the following steps:
[0052] 1) Dissolve 10.0 g of crude sodium gluconate in 190 mL of deionized water, stir and dissolve at 50°C, and add an appropriate amount of lye to adjust the pH of the solution to 6.7;
[0053] 2) Take 20g of surface-activated magnetic nanotubes and place it in a container and pump it to a vacuum state; 2) Pour the above solution into a container under vacuum state, heat and stir for adsorption for 35min, restore the normal pressure state, and continue to heat and stir for adsorption for 35min , the heating temperature is maintained at 45 ℃, so that the sodium gluconate is fully adsorbed on the inner and outer walls of the nanotubes;
[0054] 3) After the adsorption is completed, the reaction system is cooled down to room temperature, and the magnetic nanotube is separated from the solid-liquid separation through a magnetic field;
[0055] 4) ...
Embodiment 2
[0059] A method for preparing sugammadex sodium provided in the embodiment of the present invention comprises the following steps:
[0060] 1) Dissolve 20.0 g of crude sodium gluconate in 380 mL of deionized water, stir and dissolve at 50°C, and add an appropriate amount of lye to adjust the pH of the solution to 6.9;
[0061] 2) Take 35g of surface-activated magnetic nanotubes and place it in a container and pump it to a vacuum state; 2) Pour the above solution into a container under vacuum state, heat and stir for adsorption for 40min, restore the normal pressure state, and continue to heat and stir for adsorption for 40min , the heating temperature is maintained at 50 ℃, so that the sodium gluconate is fully adsorbed on the inner and outer walls of the nanotubes;
[0062] 3) After the adsorption is completed, the reaction system is cooled down to room temperature, and the magnetic nanotube is separated from the solid-liquid separation through a magnetic field;
[0063] 4) ...
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