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Copper-iron double-metal cluster-organic silica gel oxide bundle and preparation method and application of copper-iron double-metal cluster-organic silica gel oxide bundle

A technology of organosilicon oxide and copper-iron bimetal, which is applied in the direction of active ingredients of heavy metals, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., to achieve easy access to raw materials, increase CDT efficiency, and good repeatability Effect

Active Publication Date: 2022-07-22
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The purpose of the present invention is to provide a copper-iron bimetallic cluster-organic silica gel bundle and its preparation method and application, thereby solving the problem of lacking a simple and controllable method for constructing high-performance CDT nanocatalysts in the prior art

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  • Copper-iron double-metal cluster-organic silica gel oxide bundle and preparation method and application of copper-iron double-metal cluster-organic silica gel oxide bundle
  • Copper-iron double-metal cluster-organic silica gel oxide bundle and preparation method and application of copper-iron double-metal cluster-organic silica gel oxide bundle
  • Copper-iron double-metal cluster-organic silica gel oxide bundle and preparation method and application of copper-iron double-metal cluster-organic silica gel oxide bundle

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Embodiment 1

[0037] Dissolve 600 mg of F127 in 10 mL of deionized water, add 0.2 mL of NH3·H2O and 0.6 mL of MPTMS after complete dissolution, and stir at room temperature for 24 h. The well-reacted solution was transferred to a dialysis bag with a molecular weight cut-off of 14,000, and the dialysis water was replaced every 4h, and dialyzed for 24h to obtain a FOMs solution. Take 6mL of the FOMs solution obtained above and 6mL of 100mM FeCl3 6H 2 The O solution was slowly added to 18 mL of deionized water and stirred at room temperature for 24 h. After stirring was completed, the obtained product was dialyzed for 24 h to obtain Fe-FOMs. Then take 2mL of 50mM CuCl 2 ·2H 2 The O solution was added to 18 mL of the obtained Fe-FOMs aqueous solution, and then the mixed solution was stirred for 24 h. After the stirring was complete, the obtained product was dialyzed for 24 h to obtain Cu-Fe-FOMs.

[0038] figure 2 The particle size distribution statistics of each stage of synthesis in Ex...

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Abstract

The invention relates to a copper-iron double-metal cluster-organic silicon oxide bundle as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a nonionic block copolymer F127 in deionized water, and assembling to obtain an F127 micelle aqueous solution; adding a proper amount of ammonia water and a sulfydryl silane coupling agent into the aqueous solution to obtain sulfydryl-functionalized organic silicon oxide bundles; adding a ferric chloride hexahydrate solution to reduce the iron ions in a confinement manner to obtain an iron cluster-organic silicon oxide beam, and then adding a copper chloride dihydrate solution to further reduce the copper ions in a confinement manner to obtain the copper-iron bimetallic cluster-organic silicon oxide nano therapeutic agent. The dynamic particle size of the copper-iron bimetallic cluster modified organic silica gel bundle is smaller than 30 nm, the copper-iron bimetallic cluster modified organic silica gel bundle has good biological stability and dilution resistance, and the preparation method is simple. In addition, the catalytic treatment effect of tumors can be remarkably improved based on a copper-iron synergistic catalytic mechanism, and the copper-iron-based copper-iron composite material has huge application potential in the fields of biological medicine and nano-catalytic treatment.

Description

technical field [0001] The invention relates to the fields of biomedicine and nano-catalysis treatment, and more particularly relates to a copper-iron bimetallic cluster-organic oxide silica gel bundle and a preparation method and application thereof. Background technique [0002] As an emerging and effective cancer treatment strategy, chemodynamic therapy (CDT) has recently received extensive attention in the field of tumor therapy (Chem. Rev., 2021, 121(4): 1981-2019). Its therapeutic principle is based on the conversion of hydrogen peroxide (H2O2) in the tumor microenvironment (TME) under the catalysis of Fenton's reagent. 2 O 2 ) in situ into highly cytotoxic hydroxyl radicals ( OH) to induce apoptosis and inhibit tumor growth (Angew.Chem.Int.Ed., 2019, 58(4):946-956; Chem.Rev. , 2019, 119(8):4881-4985). Given H 2 O 2 The characteristic of overexpression in the TME, OH is only produced in the tumor area, with little damage to normal tissues, making CDT a new type of...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/54A61K33/34A61P35/00B82Y5/00B82Y40/00A61K33/26
CPCA61K33/34A61K33/26A61K47/6907A61K47/54B82Y5/00B82Y40/00A61P35/00A61K2300/00Y02A50/30
Inventor 牛德超李永生孙奇奇池哲人
Owner EAST CHINA UNIV OF SCI & TECH
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