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Hydrogel composition for inhibiting scar formation as well as preparation method and application thereof

A technology of hydrogel and composition, which is applied in the field of medicine, can solve the problems of air bubble wounds, need for reoperation, and easy adhesion of wounds, etc., and achieve the goals of promoting skin wound and scar healing, good biocompatibility, and pain relief Effect

Pending Publication Date: 2022-07-15
YUNNAN BOTANEE BIO TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the commonly used anti-scar treatment methods include surgery, radiotherapy, antibody injection and hormone therapy, etc. However, these treatments have a long course of treatment, low curative effect, high cost and even require reoperation
Dressings are commonly used in the market for treatment, such as natural gauze dressings, transparent film dressings, foam dressings, etc., but these dressings have their own defects, such as easy to stick to the wound surface, easy to produce air bubbles, and easy to cause maceration of the skin around the wound, etc.

Method used

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  • Hydrogel composition for inhibiting scar formation as well as preparation method and application thereof
  • Hydrogel composition for inhibiting scar formation as well as preparation method and application thereof
  • Hydrogel composition for inhibiting scar formation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A hydrogel composition for inhibiting scar formation is prepared from the following raw materials in parts by weight: 6 parts of beta-glucan, 6 parts of chitin, 180 parts of ultrapure water and 12 parts of epichlorohydrin.

[0032] A preparation method of a hydrogel composition for inhibiting scar formation, comprising the steps of:

[0033] S1, in parts by weight, take 18 parts of sodium hydroxide, 9 parts of urea, 6 parts of β-glucan, 6 parts of chitin and 180 parts of ultrapure water and mix them at -20°C to -50°C Repeated freezing and thawing 3-5 times to obtain an alkaline aqueous solution containing β-glucan and chitin;

[0034] S2, adding 12 parts of epichlorohydrin (crosslinking agent) to the alkaline aqueous solution containing β-glucan and chitin obtained in step S1, and then shaking at 0 to 15° C. to form a gel;

[0035] S3, in the gel formed in step S2, add physiological saline to shake and wash for several times until the sodium hydroxide and urea in the g...

Embodiment 2

[0037] A hydrogel composition for inhibiting scar formation is prepared from the following raw materials in parts by weight: 8 parts of beta-glucan, 7 parts of chitin, 200 parts of ultrapure water and 15 parts of epichlorohydrin .

[0038] A preparation method of a hydrogel composition for inhibiting scar formation, comprising the steps of:

[0039] S1, in parts by weight, take 20 parts of sodium hydroxide, 10 parts of urea, 8 parts of β-glucan, 7 parts of chitin and 200 parts of ultrapure water and mix them at -20 ℃ to -50 ℃ Repeated freezing and thawing 3-5 times to obtain an alkaline aqueous solution containing β-glucan and chitin;

[0040] S2, adding 15 parts of epichlorohydrin (crosslinking agent) to the alkaline aqueous solution containing β-glucan and chitin obtained in step S1, and then shaking at 0 to 15° C. to form a gel;

[0041]S3, in the gel formed in step S2, add physiological saline to shake and wash for several times until the sodium hydroxide and urea in the...

Embodiment 3

[0043] A hydrogel composition for inhibiting scar formation is prepared from the following raw materials in parts by weight: 10 parts of beta-glucan, 10 parts of chitin, 300 parts of ultrapure water and 20 parts of epichlorohydrin .

[0044] A preparation method of a hydrogel composition for inhibiting scarring mainly comprises the following steps:

[0045] S1, in parts by weight, take 25 parts of sodium hydroxide, 12 parts of urea, 10 parts of β-glucan, 10 parts of chitin and 300 parts of ultrapure water and mix them at -20°C to -50°C Repeated freezing and thawing 3-5 times to obtain an alkaline aqueous solution containing β-glucan and chitin;

[0046] S2, adding 20 parts of epichlorohydrin (crosslinking agent) to the alkaline aqueous solution containing β-glucan and chitin obtained in step S1, and then shaking at 0 to 15° C. to form a gel;

[0047] S3, in the gel formed in step S2, add physiological saline to shake and wash for several times until the sodium hydroxide and ...

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Abstract

The invention discloses a hydrogel composition for inhibiting scar formation, which is prepared from the following raw materials in parts by weight: 1 to 10 parts of beta-glucan, 1 to 10 parts of chitin, 100 to 500 parts of ultrapure water and 2 to 30 parts of cross-linking agent. The hydrogel composition disclosed by the invention is a beta-glucan-chitin hydrogel composition, has the characteristics of low toxicity, good biocompatibility, biodegradability and the like, can be used for remarkably inhibiting formation of wound scars, and can be used as an excellent candidate material for inhibiting formation of the wound scars. The invention further discloses a preparation method and application of the hydrogel composition for inhibiting scar formation.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hydrogel composition for inhibiting scar formation and a preparation method and application thereof. Background technique [0002] When the human body suffers from skin fibrosis caused by various reasons such as trauma, burns, infection, and surgery, various types of scars often appear. There are many types of scars, such as immature scars, mature scars, hypertrophic scars, and keloids. No matter what kind of scar type, it will seriously affect the quality of life of patients with skin injury, but also bring serious psychological problems, and may even affect the physiological function of the relevant organs or tissues of the body. [0003] Scars, primarily formed by disorganized networks of collagen and elastic fibers, lack functional skin appendages (eg, hair follicles and sebaceous glands). There are many factors that affect scar formation. Although the scar formation mechanism is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/722A61K47/36A61P17/02A61L26/00A61K31/716
CPCA61K31/716A61K31/722A61K9/06A61K47/36A61P17/02A61L26/0023A61L26/0066A61L26/008A61L26/009A61L2300/232A61L2300/412A61K2300/00C08L5/08C08L5/02
Inventor 李清清张继业马骁康曦萌雷佳星杨晨张沛沛王飞飞
Owner YUNNAN BOTANEE BIO TECH GRP CO LTD
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