External poloxamer gel and preparation method thereof

A technology of external gel and poloxamer, which is applied in the field of medical gel, can solve problems such as the instability of hydrophobic lactone rings, achieve the effects of improving bioavailability, maintaining blood drug concentration, and promoting body absorption

Active Publication Date: 2022-07-08
蓝科医美科学技术(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the hydrophobicity and instability of the lactone ring of turmeric root extract, its application in vivo is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] Preparation of diblock copolymers:

[0020] S1: 0.51 g of diisopropylamino-ethyl methacrylate (DIPEAMA), 1.56 mg of azobisisobutyronitrile (AIBN), 38.2 mg of 4-cyano-4[(dodecylthiocarbonyl)thio Alkyl]valeric acid and 1.5 mL of 1,4-dioxane were added to the flask. Then, the mixture was connected to the experimental device, and the mixture was frozen with liquid nitrogen, evacuated with a vacuum pump, and purged with nitrogen to normal pressure, and the cycle was repeated three times. The flask was placed in a bath at 70°C and reacted for 5h. The mixture was then concentrated, precipitated by addition of methanol, and dissolved in propylene glycol twice. The precipitate was collected and dried under vacuum to obtain a macromolecular chain transfer agent.

[0021] S2: 75 mg of macromolecular chain transfer agent, 187 mg of oligoethylene glycol methyl ether methacrylate (OEGMA) and 0.267 mg of azobisisobutyronitrile (AIBN) were added to the flask, and 0.8 mL of tetrahydr...

Embodiment 1

[0025] S1: Weigh 50mg turmeric root extract into a 5mL centrifuge tube, add 0.5g propylene glycol, vortex dispersion; add 1.0g surfactant 16-18 alcohol and A165 (ratio 1:1), vortex dispersion to prepare turmeric root extract solution.

[0026] S2: The turmeric root extract solution is dripped into the hyaluronic acid derivative aqueous solution under stirring, then moved to an ice bath, and ultrasonically treated to prepare a turmeric root extract nano-emulsion with a concentration of 10.5 μg / kg.

[0027] S3: Add 2 mL propylene glycol, 2 μL water and 0.3 mg hijiri polysaccharide solution with a concentration of 10 μg / kg to the 5 mg diblock copolymer solution, and ultrasonically treat it for 20 min; add 0.5 mg dithiothreitol, and stir at 50 °C for 3 h , dialyzed with tetrahydrofuran for 24 h to obtain a reverse micelle solution; mix 2 mL of reverse micelle solution with 500 μL of an aqueous solution with a concentration of 5 mg / mL diblock copolymer, and add 100 μL of turmeric r...

Embodiment 2

[0031] S1: Weigh 50mg turmeric root extract into a 5mL centrifuge tube, add 0.5g propylene glycol, vortex dispersion; add 1.0g surfactant 16-18 alcohol and A165 (ratio 1:1), vortex dispersion to prepare turmeric root extract solution.

[0032] S2: The turmeric root extract solution was dropped into the hyaluronic acid derivative aqueous solution under stirring, and then moved to an ice bath, and ultrasonically treated to prepare a turmeric root extract nano-emulsion with a concentration of 11.5 μg / kg.

[0033] S3: Add 2 mL propylene glycol, 2 μL water and 0.3 mg hijiri polysaccharide solution with a concentration of 10 μg / kg to the 5 mg diblock copolymer solution, and ultrasonically treat it for 20 min; add 0.5 mg dithiothreitol, and stir at 50 °C for 3 h , dialyzed with tetrahydrofuran for 24 h to obtain a reverse micelle solution; mix 2 mL of reverse micelle solution with 500 μL of an aqueous solution with a concentration of 5 mg / mL diblock copolymer, and add 100 μL of turme...

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PUM

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Abstract

The invention discloses an external poloxamer gel and a preparation method thereof. The preparation method comprises the following steps: ultrasonically dispersing poloxamer in water, and homogenizing at the temperature of 90-98 DEG C; and adding lactic acid, and uniformly stirring to obtain the poloxamer external gel. The traditional Chinese medicine composition has the functions of resisting bacteria, diminishing inflammation, healing skin and repairing scars. Wherein the components comprise lactic acid, turmeric root extract nano microemulsion and a sargassum fusiforme polysaccharide solution. The curcuma longa root extract is subjected to nano micro-emulsification, so that the problems of hydrophobicity, lactonic ring instability and the like are solved, and the curcuma longa root extract can directly act on scars through the skin. The turmeric root extract nano microemulsion and the sargassum fusiforme polysaccharide solution are coated by the diblock polymer, so that the drug release time is delayed, and the antagonism among drugs is effectively reduced.

Description

technical field [0001] The invention relates to the technical field of medical gels, in particular to a poloxamer gel for external use and a preparation method thereof. Background technique [0002] Poloxamer is a polyoxyethylene polyoxypropylene block copolymer and a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer. It is a good drug carrier and is conducive to direct drug administration through the skin, avoiding The occurrence of some adverse reactions. [0003] Scar is a benign tumor. At present, traditional treatment methods include laser therapy, cryotherapy, glucocorticoid injection, etc., which also have certain effects, but generally have large side effects and cause obvious skin damage. Turmeric root extract is a representative of turmeric root extract derivatives, which can effectively hinder DNA replication, prevent mitosis, inhibit cell proliferation, and is a good anti-tumor agent. However, the in vivo application of turmeric root extract i...

Claims

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Application Information

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IPC IPC(8): A61K47/10A61K9/06A61K36/9066A61K31/715A61P17/02
CPCA61K47/10A61K9/06A61K9/0014A61K36/9066A61K31/715A61P17/02A61K2300/00Y02A50/30
Inventor 曹原眭春魏明明夏翡翡孙玮哲周兰
Owner 蓝科医美科学技术(吉林)有限公司
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