External poloxamer gel and preparation method thereof
A technology of external gel and poloxamer, which is applied in the field of medical gel, can solve problems such as the instability of hydrophobic lactone rings, achieve the effects of improving bioavailability, maintaining blood drug concentration, and promoting body absorption
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[0019] Preparation of diblock copolymers:
[0020] S1: 0.51 g of diisopropylamino-ethyl methacrylate (DIPEAMA), 1.56 mg of azobisisobutyronitrile (AIBN), 38.2 mg of 4-cyano-4[(dodecylthiocarbonyl)thio Alkyl]valeric acid and 1.5 mL of 1,4-dioxane were added to the flask. Then, the mixture was connected to the experimental device, and the mixture was frozen with liquid nitrogen, evacuated with a vacuum pump, and purged with nitrogen to normal pressure, and the cycle was repeated three times. The flask was placed in a bath at 70°C and reacted for 5h. The mixture was then concentrated, precipitated by addition of methanol, and dissolved in propylene glycol twice. The precipitate was collected and dried under vacuum to obtain a macromolecular chain transfer agent.
[0021] S2: 75 mg of macromolecular chain transfer agent, 187 mg of oligoethylene glycol methyl ether methacrylate (OEGMA) and 0.267 mg of azobisisobutyronitrile (AIBN) were added to the flask, and 0.8 mL of tetrahydr...
Embodiment 1
[0025] S1: Weigh 50mg turmeric root extract into a 5mL centrifuge tube, add 0.5g propylene glycol, vortex dispersion; add 1.0g surfactant 16-18 alcohol and A165 (ratio 1:1), vortex dispersion to prepare turmeric root extract solution.
[0026] S2: The turmeric root extract solution is dripped into the hyaluronic acid derivative aqueous solution under stirring, then moved to an ice bath, and ultrasonically treated to prepare a turmeric root extract nano-emulsion with a concentration of 10.5 μg / kg.
[0027] S3: Add 2 mL propylene glycol, 2 μL water and 0.3 mg hijiri polysaccharide solution with a concentration of 10 μg / kg to the 5 mg diblock copolymer solution, and ultrasonically treat it for 20 min; add 0.5 mg dithiothreitol, and stir at 50 °C for 3 h , dialyzed with tetrahydrofuran for 24 h to obtain a reverse micelle solution; mix 2 mL of reverse micelle solution with 500 μL of an aqueous solution with a concentration of 5 mg / mL diblock copolymer, and add 100 μL of turmeric r...
Embodiment 2
[0031] S1: Weigh 50mg turmeric root extract into a 5mL centrifuge tube, add 0.5g propylene glycol, vortex dispersion; add 1.0g surfactant 16-18 alcohol and A165 (ratio 1:1), vortex dispersion to prepare turmeric root extract solution.
[0032] S2: The turmeric root extract solution was dropped into the hyaluronic acid derivative aqueous solution under stirring, and then moved to an ice bath, and ultrasonically treated to prepare a turmeric root extract nano-emulsion with a concentration of 11.5 μg / kg.
[0033] S3: Add 2 mL propylene glycol, 2 μL water and 0.3 mg hijiri polysaccharide solution with a concentration of 10 μg / kg to the 5 mg diblock copolymer solution, and ultrasonically treat it for 20 min; add 0.5 mg dithiothreitol, and stir at 50 °C for 3 h , dialyzed with tetrahydrofuran for 24 h to obtain a reverse micelle solution; mix 2 mL of reverse micelle solution with 500 μL of an aqueous solution with a concentration of 5 mg / mL diblock copolymer, and add 100 μL of turme...
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