Hydantoin precursor solution and method for preparing glycine by using hydantoin precursor solution

A technology of precursor solution and glycine, which is applied in the preparation of cyanide reaction, chemical instruments and methods, and the preparation of organic compounds, etc., can solve the problem that it is difficult to fully convert hydantoin into glycine products, and achieve good industrial application promotion value and high yield , the effect of low synthetic energy consumption

Pending Publication Date: 2022-05-17
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the object of the present invention is to provide a hydantoin precursor solution and a method for preparing glycine using the hydantoin precursor solution, which solves the problem that hydantoin in the existing direct hydantoin method is completely difficult to fully convert into glycine by self-hydrolysis product problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 (preparation of hydantoin precursor solution, 10min, 80°C)

[0030] 23w% ammonium bicarbonate aqueous solution is pumped into the primary tubular reactor at 33L / min and preheated to 80°C and continues to enter the secondary tubular reactor, 45w% hydroxyacetonitrile material (pH=3, solvent is water) with 5L / min enters the secondary tubular reactor, the temperature of the secondary tubular reactor is controlled at 80°C, the material ratio in the reactor is hydroxyacetonitrile: carbon dioxide: ammonia: water = 1:2:4:39.6, and the reaction stays for 10 minutes. A light yellow hydantoin precursor was obtained at the outlet of the first-stage reactor. According to HPLC analysis, hydantoin amide accounted for 72.54% of the precursor liquid components, hydantoin accounted for 24.23%, and the remaining hydantoinic acid, glycine amide, and glycine accounted for about 3.23% in total.

Embodiment 2

[0031] Example 2 (preparation of hydantoin precursor solution, 5min, 90°C)

[0032] 23w% ammonium bicarbonate aqueous solution is pumped into the primary tubular reactor at 33L / min and preheated to 80°C and continues to enter the secondary tubular reactor, 45w% hydroxyacetonitrile material (pH=5, solvent is water) with 5L / min enters the secondary tubular reactor, the temperature of the secondary tubular reactor is controlled at 90°C, the material ratio in the reactor is hydroxyacetonitrile: carbon dioxide: ammonia: water = 1:2:4:39.6, and the reaction stays for 5 minutes. A light yellow hydantoin precursor solution was obtained at the outlet of the first-stage reactor. According to HPLC analysis, hydantoin amide accounted for 77.54%, hydantoin accounted for 18.42%, and the remaining hydantoinic acid, glycine amide, and glycine accounted for about 4.04% in total.

Embodiment 3

[0035] Example 3 (hydantoin precursor solution, 2min, 100°C)

[0036] 23w% ammonium bicarbonate aqueous solution is pumped into the primary tubular reactor at 33L / min and preheated to 100°C and continues to enter the secondary tubular reactor, 45w% hydroxyacetonitrile material (pH=2, solvent is water) with 5L / min enters the secondary tubular reactor, the temperature of the secondary tubular reactor is controlled at 100°C, the material ratio in the reactor is hydroxyacetonitrile: carbon dioxide: ammonia: water = 1:2:4:39.6, and the reaction stays for 2 minutes. A light yellow hydantoin precursor was obtained at the outlet of the first-stage reactor. According to HPLC analysis, hydantoin amide accounted for 80.54%, hydantoin accounted for 13.79%, and the remaining hydantoin acid, glycine amide, and glycine accounted for about 5.67%.

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Abstract

The invention relates to the technical field of organic chemical industry, in particular to a hydantoin precursor solution and a method for preparing glycine by using the hydantoin precursor solution, the hydantoin precursor solution is an aqueous solution containing hydantoin amide and hydantoin components, and the molar ratio of the hydantoin amide to the hydantoin in the components is not lower than 2: 1; the method comprises the following steps: reacting a hydroxyacetonitrile material with a carbon dioxide source, an ammonia source and water in a synthesis device at 80-100 DEG C to prepare a hydantoin precursor solution, enabling the obtained hydantoin precursor solution to enter a hydrolysis device to contact with a solid catalyst containing a metal oxide, and hydrolyzing at 70-120 DEG C to obtain glycine hydrolysate; after the solid catalyst is separated from the glycine hydrolysate through the solid-liquid separation device, the glycine hydrolysate is concentrated and deaminated and then fed into the spraying device to be subjected to spray drying to obtain a glycine product, and the separated solid catalyst is returned to the hydrolysate device to be recycled. According to the method, the problem that hydantoin completely depends on self-hydrolysis and is difficult to be fully converted into a glycine product in an existing direct hydantoin method is solved.

Description

technical field [0001] The invention relates to the technical field of organic chemical industry, in particular to a hydantoin precursor solution and a method for preparing glycine using the hydantoin precursor solution. Background technique [0002] Glycine (abbreviated as GLY), also known as aminoacetic acid or tyrosine, is the α-amino acid with the smallest relative molecular mass and the simplest structure, and is widely used in pesticides, chemicals, medicines, daily chemicals, food and other industries. [0003] At present, industrially, glycine is mainly obtained by chemical synthesis, which can be divided into chloroacetic acid method, Strecker method, improved Strecker method, direct Hain method and the like according to different processes. The chloroacetic acid method uses chloroacetic acid and ammonia as raw materials to obtain glycine and the by-product salt ammonium chloride under the action of urotropine. This method has a short process and easy access to raw ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/24C07C227/40C07C227/42C07C229/08
CPCC07C227/24C07C227/40C07C227/42C07C229/08
Inventor 廖常福周荣超彭启明周振宇吴传隆赵加丽杨晓泉
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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