Method for treating ulcerative lesions by using marine drugs

A marine and pharmaceutical technology, which is applied in the direction of drug combination, pharmaceutical formula, and medical raw materials derived from cnidaria, can solve the problems of easy infection and long treatment period, and achieve easy drying microenvironment, good convergence and anti-inflammation, The effect of scavenging active oxygen free radicals

Pending Publication Date: 2022-04-29
SHANGHAI QUANREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The course of treatment for deep second-degree burns is relatively long, and infection is prone to occur. At present, most wounds are covered with anti-inflammatory plasters or burn plasters, such as erythromycin ointment, moist burn ointment
However, this method cannot fundamentally form a therapeutic effect

Method used

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  • Method for treating ulcerative lesions by using marine drugs
  • Method for treating ulcerative lesions by using marine drugs
  • Method for treating ulcerative lesions by using marine drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This example provides an application of marine traditional Chinese medicine in treating diabetic skin ulcers. The marine traditional Chinese medicine is a medicine for external application, and the marine traditional Chinese medicine described in this embodiment is prepared by adding hydrogenated coral calcium and conventionally used auxiliary materials in the prior art to make a medicine for external application.

[0037] 1. Experimental animals:

[0038] Strain: SD rat, sex: female, body weight: 180 g.

[0039] 2. Test groups

[0040] Diabetes has a certain rate of modeling, the blank group (5), the model group (13), the experimental group (10).

[0041] 3. Test method

[0042] 3.1 Preparation of diabetic rat model

[0043] 50 SD male rats, weighing 120±g, were selected, and 5 rats were placed in a cage. Feed with high-fat and high-sugar feed (10% of lard, 20% of sucrose, 3% of egg yolk, 67% of basal feed), at room temperature of 20°C-24°C, free to eat and drink,...

Embodiment 2

[0072] This example provides an application of marine traditional Chinese medicine for oral ulcers. The marine traditional Chinese medicine is a medicine for external application, and the marine traditional Chinese medicine described in this embodiment is prepared by adding hydrogenated coral calcium and conventionally used auxiliary materials in the prior art to make a medicine for external application.

[0073] 1. Experimental animals:

[0074] Strain: SD rat, sex: female, body weight: 180 g.

[0075] 2. Test groups

[0076] Blank group (3 rats), model group (11 rats), and experimental group (10 rats).

[0077] 3. Test method

[0078] 3.1 Modeling:

[0079] 7-week-old SD rats were selected, fed with a standard diet, without water restriction, and the indoor temperature was kept at (22±2)°C. The middle interval is 1d. After the rats were anesthetized, a cotton ball containing 60% glacial acetic acid was placed flat on the buccal membrane and the inner side of the lower ...

Embodiment 3

[0105] This embodiment provides an application of marine traditional Chinese medicine in extravasation of chemotherapeutic drugs and deep second-degree burns. The marine traditional Chinese medicine is a medicine for external application, and the marine traditional Chinese medicine described in this embodiment is prepared by adding hydrogenated coral calcium and conventionally used auxiliary materials in the prior art to make a medicine for external application.

[0106] 1. Experimental animals:

[0107] Strain: C57 mouse, sex: female, body weight: 20 g.

[0108] 2. Test groups

[0109] Model group (5 rats), experimental group (6 rats).

[0110] 3. Test method

[0111] 3.1 Modeling:

[0112] 6-week-old C57 mice were selected, fed with a standard diet, without water restriction, and the indoor temperature was kept at (22±2)°C. The middle interval is 1d. Mice were anesthetized and depilated on the back. Epirubicin 0.1 ml at a concentration of 0.25 mg / ml was injected subcu...

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Abstract

The invention relates to an application of a marine traditional Chinese medicine in preparing a medicine for treating skin ulceration and deep II-degree burn caused by diabetic skin ulcer, oral ulcer, chemotherapeutic drug extravasation, radioactive skin injury and fungal infection. The marine traditional Chinese medicine is a hydrogen molecule solid carrier, that is, the marine traditional Chinese medicine is prepared by curing hydrogen molecules on an edible solid carrier, and after the marine traditional Chinese medicine is taken into a human body, the marine traditional Chinese medicine encounters water in the human body to release the hydrogen molecules so as to target ulcers or damaged parts to diffuse, remove reactive oxygen free radicals and relieve oxidative damage; therefore, the purpose of curing skin ulcers such as diabetic skin ulcers, oral ulcers, chemotherapeutic drug exosmosis, radioactive skin injury, skin ulceration caused by fungal infection, deep second-degree burn and the like is achieved. Compared with the existing medicine, the marine medicine disclosed by the invention is easier to penetrate through a cell membrane structure and has better effects of astringing, resisting inflammation and removing reactive oxygen free radicals so as to relieve oxidative damage.

Description

technical field [0001] The invention belongs to the technical field of medicines, and specifically relates to the application of a marine traditional Chinese medicine in the preparation of medicines for treating diabetic skin ulcers, oral ulcers, extravasation of chemotherapeutic drugs, radiation skin damage, skin ulcers caused by fungal infections, and second-degree burns. Background technique [0002] Diabetic skin ulcer is a relatively common complication of diabetes. It mostly occurs on the feet of patients, so it is also called diabetic foot. Severe disease will directly affect the treatment effect of diabetes, and even lead to amputation and death. At present, there are various medicines for treating diabetic skin ulcers, but the therapeutic effect is not satisfactory. [0003] Chemotherapy drug treatment is one of the main means of malignant tumor treatment, and most chemotherapy drugs are injected intravenously, and extravasation of drugs through needles often cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K35/614A61P17/02A61P1/02
CPCA61K33/00A61K35/614A61K9/0014A61P17/02A61P1/02
Inventor 于观贞李朝阳车奇威廖心怡潘雅婷
Owner SHANGHAI QUANREN BIOTECH
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