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Porous materials with micron scale features

A technology of scale, porous membrane, applied in the field of porous materials, which can solve the problems such as the limitation of extrusion technology complexity, low output, and UV curing technology obstacles.

Pending Publication Date: 2022-04-12
RGT UNIV OF MICHIGAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, extrusion cannot produce materials with high porosity percentages (e.g., greater than about 30% by volume) while maintaining micron-scale features
Furthermore, extrusion technology is limited in the complexity of the shapes that can be produced
3D printing is increasingly moving towards micron-scale production, but UV curing, by far the most common type of 3D printing technology, is hampered by "bleed" characteristics, especially at small scales
Therefore, 3D printing technology is limited in both the achievable feature size and the aspect ratio of the printed material
Dip-coating can be used to generate micron-scale features from porous polymers at high aspect ratios, but is limited to simple shapes as a batch process and yields are not high

Method used

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  • Porous materials with micron scale features
  • Porous materials with micron scale features
  • Porous materials with micron scale features

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0177] Example 1 - Embossed sheet with linear features and inherent porosity

[0178] During the development of embodiments of the technology provided herein, experiments were performed to produce (see, eg, Materials and Methods), test and / or characterize embossed sheets with linear characteristics and inherent porosity. Polymer membranes were fabricated by casting a composition comprising polycaprolactone (PCL) and NaCl as a porogen. In an exemplary embodiment, the membrane comprises 70% by volume of NaCl porogen that has been pre-ground to a diameter of less than 20 μm. Embossing of polymer membranes on embossing blocks at 21 °C, 40 °C and 60 °C (see, e.g., figure 1 ). After embossing the polymeric membrane, the NaCl porogen was removed from the membrane by washing the membrane in water.

[0179] Measurements of the membranes indicated that the membranes had linear characteristics and inherent porosity maintained after removal of the porogen. In particular, micrographs o...

Embodiment 2

[0180] Example 2 - Embossing incorporating spacer material

[0181] During the development of embodiments of the technology provided herein, experiments were performed to produce (see, eg, Materials and Methods), test, and / or characterize porous materials comprising void spaces (eg, linear void spaces). Two sheets of polymeric film and a series of spacer wires (placed between the polymeric film sheets) were embossed on an embossing block (see, eg, Materials and Methods). In an exemplary embodiment, the wire is stainless steel and coated with polyvinyl alcohol. After applying pressure, the spacer wire is removed.

[0182] Examination of a polymer film embossed with a spacer wire showed that placing a spacer (e.g., a wire mandrel coated with polyvinyl alcohol (PVA)) into a feature creates a filled design and the spacer can be removed to create a void space. image 3 , Figure (a) shows the wire spacers in the embossed sheet from a side view, while image 3 , Figure (b) shows ...

Embodiment 3

[0183] Example 3 - Embossing Apparatus

[0184] During the development of embodiments of the technology provided herein, experiments were performed to produce (see, e.g., Materials and Methods; see also Figure 5 , Figure (a)), testing and / or characterizing devices comprising porous polymeric materials and micron-scale features (see, e.g., Figure 5 , Figures (a) to (c)). Polymer films were produced and materials containing void spaces were produced (see, eg, Materials and Methods and Example 2). The material is coiled and inserted into a tube to create an embossed device (see, e.g., Figure 4 , Figure (b) and Figure 5 , Figure (c)).

[0185] Inspection of embossing device ( Figure 4 , panel (b)) shows that it is very similar to microchannel devices fabricated using the dip-coating method (see, e.g., Figure 4 , Figure (a)). However, devices produced according to the embossing techniques presented herein are improved in several respects relative to devices produced by...

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Abstract

Provided herein are techniques relating to materials having micro-scale and / or nano-scale features, and in particular, but not exclusively, to porous materials comprising micro-scale features; a method for producing a porous material comprising microscale features; a drug delivery vehicle; and related kits, systems and uses.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application Serial No. 62 / 790,178, filed January 9, 2019, which is incorporated by reference as if fully set forth herein. technical field [0003] Provided herein are technologies related to materials having microscale and / or nanoscale features, and in particular, but not exclusively, to porous materials comprising microscale features; methods for producing porous materials comprising microscale features; drug delivery carrier; and related kits, systems and uses. Background technique [0004] Inherently porous materials with micron-scale features (eg, in the range of about 10 μm to 1 mm) and high aspect ratios are difficult to manufacture at scaled-up production volumes and / or at high yields. While methods exist for producing materials with features in the micrometer-scale range, these existing techniques are of limited utility. For example, conventional processing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56B29C59/02C08J5/18
CPCB32B1/00B32B2264/108B32B27/36B32B2264/107B32B2535/00B32B2250/02B32B2264/104B32B3/26B32B2307/732B32B2264/102B32B27/20B32B27/08B32B2250/24B29C2059/023A61L27/56A61L2300/102A61L2430/32A61L27/18A61L27/44A61L27/54C08L67/04C08K3/042C08J5/18C08J2367/04C08K2003/325C08K2201/011A61F2/02A61F2002/30316A61M31/002C08K3/36
Inventor 马克·H·图申斯基杰弗里·S·萨卡莫托肯德尔·M·帕韦莱茨雅各布·M·科夫勒迈克尔·赛勒乔纳森·祖徳马
Owner RGT UNIV OF MICHIGAN
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