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Preparation method of wearable hydrogel glucose sensor

A glucose sensor and hydrogel technology, applied in the field of biomedical sensing, can solve the problems of adjustment, discontinuity, and high frequency of the unfavorable doctor's judgment plan, and achieve the effect of flexible writing, improved transparency, and simple preparation process

Active Publication Date: 2022-04-05
汕头大学·香港中文大学联合汕头国际眼科中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although relatively simple, there are disadvantages such as invasiveness, discontinuity, and high frequency, which bring physical pain to patients, and discrete data is not conducive to doctors' judgment of the condition and adjustment of the plan
The second method is a continuous blood glucose monitoring system. Although it overcomes the shortcomings of being unable to measure continuously, this method is still invasive and requires regular calibration and replacement.

Method used

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  • Preparation method of wearable hydrogel glucose sensor
  • Preparation method of wearable hydrogel glucose sensor
  • Preparation method of wearable hydrogel glucose sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0032] 30% (w / v) acrylamide solution, 10wt% sodium dodecyl sulfate (SDS), 10wt% ammonium persulfate (AP), 10wt% N,N,N',N'-methylethylenediamine (TEMED) and 20mol% 3-acrylamidophenylboronic acid (3-APBA) solution (3-APBA was dissolved in 10M NaOH) were mixed to obtain a prepolymer solution, and 80ul was quickly sucked and dropped onto a glass slide, in order to maintain the thickness of the film Homogenize, add a cover glass on top, and let it stand at room temperature for 1.5h to obtain a transparent hydrogel film.

[0033] Place the hydrogel film on the three-axis displacement stage of the femtosecond laser, use 520nm visible light to write the grating, and use the camera system to observe the writing process in real time. The distance between the laser lens and the hydrogel film is 4um, and the writing rate is 100um / s, write power 0.282uJ, get a wearable hydrogel glucose sensor (ie grating sensor).

[0034] The amounts of raw materials in Examples 1-5 are respectively shown...

Embodiment 6

[0050] The same as embodiment 1, the difference is that a grating is written using a mask to obtain a grating sensor.

Embodiment 7

[0052] Mix acrylamide, N, N'-methylene bis(acrylamide), 3-acrylamidophenylboronic acid at a ratio of 78.5mol%: 1.5mol%: 20mol% to obtain a mixed solution, and then add 1ml of dimethylmethylene Sulfone, then add photoinitiator DEAP (20ul) or DAMP (2% (w / v)), fully dissolve after stirring at room temperature; drop the above solution onto the glass slide, in order to maintain a uniform thickness, add a cover glass on the top After irradiating with ultraviolet light (365nm) for 10min, a transparent and uniform hydrogel film was obtained.

[0053] Other operations are the same as in Example 1.

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Abstract

The invention discloses a preparation method of a wearable hydrogel glucose sensor, and belongs to the technical field of biomedical sensing. Polyacrylamide hydrogel is adopted as a basic material, phenylboronic acid groups capable of recognizing glucose molecules are added, a hydrogel film is prepared, grating inscribing is conducted on the hydrogel film in a femtosecond laser direct writing mode, and the wearable hydrogel glucose sensor is obtained. The hydrogel film is combined with glucose to present linear expansion, so that the grating period and the effective refractive index are changed. The quantitative measurement of glucose is realized by detecting the spatial position of a diffraction spectrum band and the diffraction light intensity change. The wearable hydrogel glucose sensor prepared by the invention is placed on eyes during application, and the transparent hydrogel film can noninvasively monitor the tear glucose concentration while not influencing the eyesight of a patient, so that the glucose content in a body is effectively reflected.

Description

technical field [0001] The invention relates to the technical field of biomedical sensing, in particular to a preparation method of a wearable hydrogel glucose sensor. Background technique [0002] Diabetes is a vascular disease with a high incidence in the world, and its harm lies in its many complications and serious impact. For diabetics, blood sugar monitoring is particularly important. At present, there are two methods of blood glucose monitoring. The first method is to reflect the glucose concentration through a blood glucose meter, which requires pricking the skin of a finger and taking peripheral blood for inspection. Although it is relatively simple, it has disadvantages such as invasiveness, discontinuity, and high frequency, which bring physical pain to patients, and discrete data is not conducive to doctors' judgment of the disease and adjustment of the plan. The second method is a continuous blood glucose monitoring system. Although it overcomes the disadvanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/41G01N21/25G02B5/18A61B3/10
CPCA61B5/14532A61B2562/12A61B5/14507A61B5/6821C08J5/18C08J2333/26C08J3/075
Inventor 张铭志曲航胡学浩温鑫
Owner 汕头大学·香港中文大学联合汕头国际眼科中心
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