Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Utilization method of 7-aminocephalosporanic acid production waste

A technology of amino cephalosporanic acid and waste, applied in the direction of fertilizer mixture, organic fertilizer, nitrogen fertilizer, etc., can solve the problems of limited application range, destruction of amino acid nutrition, large energy consumption, etc., to solve product cost and price upside down, bacteria The effect of reducing the physical volume of the body and saving energy consumption

Pending Publication Date: 2022-03-25
HEZE RUIZHI TECH DEV
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Three patents with authorization numbers CN102392008B, CN108048519B and publication number CN101935682A respectively provide a technical solution for cephalosporin C residues to replace part of the fermentation medium components for recycling, but only part of the residues can be applied mechanically; the patent with publication number CN109776238A provides A technical solution for producing amino acid fertilizer by using strong acid to decompose cephalosporin C filter residue, but there are disadvantages that some types of amino acid are destroyed by strong acid, the nutrition of amino acid is not comprehensive, and there are a large amount of salt in the product, and the application range is limited
At present, the outlet of most cephalosporin C bacteria residues is to use them in the production of organic fertilizer after being dried, and the economic value is extremely low; the drying method adopted by a few manufacturers uses plate and frame pressing to remove part of the water before drying, which can save Part of the cost of steam, but due to the presence of a large amount of colloidal substances in the fungus residue, the operability is poor, which will cause secondary pollution. Therefore, most manufacturers currently use the method of directly drying the wet fungus residue by drum or spray drying. No matter what drying method is required A large amount of energy is consumed, and the residue of cephalosporin C has not been completely eliminated, so there are certain potential safety hazards
[0004] ɑ-Aminoadipic acid is the main waste in the production of 7-ACA except cephalosporin C residue. Since there is no good market use, it basically enters the sewage treatment plant with the waste liquid extracted from 7-ACA , which is the main reason for the extraction waste liquid to become high COD wastewater

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Utilization method of 7-aminocephalosporanic acid production waste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The present embodiment provides a method for utilizing 7-aminocephalosporanic acid production waste, comprising the following steps:

[0037] (1) 500L of fresh fungus residue, the detected bacteria concentration is 86%, the solid content is 15.3%, adjust the pH to 5.8 with liquid caustic soda, add 45L of prepared Aspergillus oryzae lyase, add 40g of chitinase (100,000 U / g ), enzymatic hydrolysis at 58°C for 70h. The bacterial cell concentration of the enzymatic hydrolysis liquid was detected to be 14%, the liquefaction rate of organic matter was 83.6%, and the residue of cephalosporin C was not detected.

[0038] (2) 31.2 kg of substances such as calcium oxalate and some fibers were removed from the enzymatic hydrolysis solution by a decanter centrifuge.

[0039] (3) 50nm ceramic membrane ultrafiltration, during which water was added twice, 100L each time, and 625.5L of filtrate and 88.5L of filter residue were collected respectively.

[0040] (4) Concentrate the ultr...

Embodiment 2

[0043] The present embodiment provides a method for utilizing 7-aminocephalosporanic acid production waste, comprising the following steps:

[0044] (1) 920L of fresh bacterial residue, add 80L of ultrafiltration residue collected in step (3) of Example 1, mix, detect bacterial cell concentration 84.8%, solid content 15.1%, adjust PH5.8 with liquid caustic soda, add prepared rice Aspergillus lyase 88L, Aspergillus niger lyase 10L, add chitinase 60g (100,000 U / g), enzymolysis at 57°C for 70h. The concentration of bacteria in the enzymatic hydrolysis solution was 13.4%, the liquefaction rate of organic matter was 85.9%, and the residue of cephalosporin C was not detected.

[0045] (2) 72.3 kg of substances such as calcium oxalate and fiber were removed from the enzymatic hydrolysis solution by a continuous sedimentation centrifuge

[0046] (3) The centrifugate was ultrafiltered with a 20nm ceramic membrane, during which water was added twice, 150L each time, and the filtrate 11...

Embodiment 3

[0065] Add 15kg of plant stalks or the last batch of dry organic fertilizer raw materials to 72.3kg of centrifuged slag in Example 2, adjust the moisture content, insert Aspergillus oryzae ¸ Aspergillus niger or organic fertilizer composite strains for accumulation and fermentation, and turn the pile in the middle for 3-5 Lower the temperature for the second time. After the temperature drops, the moisture content is detected to be 21.6%. Spread it out to dry or dry until the moisture content is ≤15%, which is the basic raw material of organic fertilizer.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a utilization method of 7-aminocephalosporanic acid production waste, which comprises the following steps: (1) adjusting the pH value of fresh cephalosporin C wet mushroom dregs to 5.5-6.0 by using alkali, adding a complex enzyme preparation in a certain proportion, and carrying out enzymolysis at 55-60 DEG C for 48-72 hours; (2) separating the enzymatic hydrolysate by using a settling centrifuge to remove calcium oxalate salt and part of fibers, wherein the calcium oxalate salt and part of fibers can be used as organic fertilizer raw materials; (3) the centrifugate is treated with ceramic membrane ultrafiltration equipment, filtrate and filter residues are collected respectively, one part of the ultrafilter residues serve as a fermentation preparation culture medium of aspergillus oryzae or aspergillus niger liquid enzyme, and the other part of the ultrafilter residues are added into the next batch of cephalosporin fresh fungus residues for secondary enzymolysis; (4) carrying out nanofiltration concentration on the ultrafiltrate; and (5) alpha-aminoadipic acid is added into the nanofiltration concentrated solution in the step (4) for blending, the amino acid liquid fertilizer or a production raw material thereof is obtained, and the alpha-aminoadipic acid is derived from 7-ACA extraction mother liquor.

Description

technical field [0001] The invention relates to the technical field of environmental protection wastewater treatment, in particular to a method for utilizing 7-aminocephalosporanic acid production waste. Background technique [0002] Cephalosporins account for about 40% of the market share of anti-infective drugs due to their good curative effect and low allergies. The main raw material for its production is 7-aminocephalosporanic acid (7-ACA), which is produced by enzymatic cracking of cephalosporin C of. Cephalosporin C was produced by fermentation of Cephalosporium acremonium, and the residue was removed by ultrafiltration, and α-aminoadipic acid was excised by immobilized cephalosporin C acylase to produce 7-ACA. Cephalosporin C residue and α-aminoadipic acid were the two most important production wastes in 7-ACA production. [0003] Cephalosporin C residues contain cephalosporin C residues, which are listed as hazardous waste by the state and are subject to strict sup...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C05C11/00C05F11/00C05G5/20
CPCC05C11/00C05F11/00C05G5/20
Inventor 于海勤张杰吴桂苹
Owner HEZE RUIZHI TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com