VEGFR (vascular endothelial growth factor receptor) targeting cracking peptide conjugate and application thereof
A conjugated and targeted technology, applied in the field of bioengineering, can solve the problems of unreported cleavage peptide combined with anti-VEGFRACE treatment research and other problems, and achieve the effect of increasing killing effect, increasing selectivity and inhibiting signaling pathway.
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[0024] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.
[0025] 1. Design of cleavage peptide-polypeptide conjugates targeting VEGFR
[0026] The present invention adopts the coupling of VEGFR polypeptide ligand and cleavage peptide to form bifunctional polypeptide drug, such as figure 1 As shown, we selected the previously reported VEGFR polypeptide ligand (polypeptide sequence: glutamine-lysine-arginine-lysine-arginine-lysine-lysine-serine-arginine- Tyrosine-lysine-serine) and cleavage peptide (polypeptide sequence: lysine-leucine-2-aminoisobutyric acid-lysine-leucine-2-aminoisobutyric acid-lysine -lysine-leucine-2-aminoisobutyric acid-lysine-leucine-2-aminoisobutyric acid-lysine) combination, in an attempt to increase the targeted toxicity to VEGFR high-expressing cel...
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