Medical catheter hydrogel coating as well as preparation method and application thereof

A technology of medical catheters and hydrogels, applied in coatings, catheters, pharmaceutical formulations, etc., can solve problems such as difficult attachment of microspheres, difficult use of catheters, easy water absorption, swelling and falling off, etc., to achieve good adhesion and reduce discomfort , Improve the effect of adhesion

Active Publication Date: 2022-03-15
广东省科学院生物与医学工程研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the hydrophobicity, oleophobicity and inertness of silicone rubber itself, it is particularly difficult to modify the surface
When conventional hydrophilic hydrogel is coated on the surface of silicone rubber for coating and modification, the operation steps are complicated, and it is easy to absorb water and swell and fall off when it is placed in water, making it difficult to form a stable surface coating, especially for indwelling catheters. The service environment of urinary catheters usually has water and the time in the body varies from hours to weeks. Therefore, the application of hydrogel coatings has great limitations and is difficult to use in urinary catheters.
In addition, in the existing microsphere drug-loaded catheters, it is difficult for the microspheres to adhere to the surface of the catheter, mainly because the size (ie thickness) of the hydrogel coating is difficult to adjust
Many current surface coatings of urinary catheters are mainly self-forming coatings (such as dopamine-modified chitosan, hyaluronic acid coatings, etc.), but these coatings are thin, and in addition, during the coating formation process Microspheres are difficult to attach to the surface of urinary catheters, making the application of microspheres limited

Method used

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  • Medical catheter hydrogel coating as well as preparation method and application thereof
  • Medical catheter hydrogel coating as well as preparation method and application thereof
  • Medical catheter hydrogel coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] This embodiment prepares a kind of medical catheter hydrogel coating, and the specific process is:

[0051] S1: Get 1788 type polyvinyl alcohol (PVA), be prepared into the PVA solution that mass fraction is 15%, add the methyltrimethoxysilane (MTMS) that 0.04g concentration is 37% and 0.9g in every 15g solution, After being evenly stirred by a magnetic stirrer, it was hydrolyzed at room temperature for 48 hours;

[0052] S2: Pour the prepared hydrogel into a mold, then freeze at a low temperature for 24 hours, take it out and put it into a freeze dryer for freeze-drying. After freeze-drying, cut it from the middle, spray gold, and observe it under a scanning electron microscope.

[0053] Among them, the SEM image of the PVA / MTMS hydrogel after freeze-drying is as follows: figure 1 shown.

[0054] from figure 1 It can be seen that the PVA / MTMS hydrogel presents a dense porous structure.

Embodiment 2

[0056] like figure 2 As shown, the present embodiment prepares a silicone rubber coated with a medical catheter hydrogel coating, and the specific process is:

[0057] S1: Preparation of silicone rubber (PDMS): Take Dow Corning 184 glue, mix according to the ratio of glue:curing agent 9:1, after stirring well, remove air bubbles in vacuum, import it into the mold and cure it at 70°C for 2 hours;

[0058] S2: Preparation of hydrogel: get 1788 type polyvinyl alcohol (PVA), be mixed with the PVA solution that the mass fraction is 15%, add 0.04g concentration to be 37% HCl and the methyl trimethoxy of 0.9g in every 15g solution Silane (MTMS) is prepared by hydrolysis after being stirred evenly by a magnetic stirrer and standing at room temperature for 48 hours;

[0059] S3: Preparation of silane-containing silicone rubber: take Dow Corning 184 glue, mix according to the ratio of glue:curing agent 9:1, then add methyltrimethoxysilane with a mass fraction of 2%, stir evenly, and v...

Embodiment 3

[0063] In this example, a silicone rubber coated with a hydrogel coating for a medical catheter is prepared. The preparation method is the same as in Example 2, except that the concentration of the PVA solution is different. In this example, the concentration of the PVA solution is 10%.

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Abstract

The invention provides a medical catheter hydrogel coating as well as a preparation method and application thereof, the medical catheter hydrogel coating comprises a high polymer material layer and a polyvinyl alcohol layer crosslinked on the high polymer material layer, the high polymer material layer contains a silane coupling agent, and the polyvinyl alcohol layer is modified by a trimethoxysilane coupling agent. The surface of the medical catheter can be lubricated, the medical catheter can be firmly attached to the medical catheter, the medical catheter does not fall off, excellent stability can be kept in liquid, and great application potential is achieved. According to the preparation method of the medical catheter hydrogel coating, the mode of cooling crosslinking and then thermal crosslinking is adopted, and the adhesive force of the coating on the surface of a base material is remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a hydrogel coating for a medical catheter and a preparation method and application thereof. Background technique [0002] Urinary catheter is a common method to solve urinary retention, dysuria, urinary drainage and bladder flushing after surgery. Infection is often prone to occur during the use of urinary catheters. At present, urinary tract infections account for 35% to 50% of total hospital infections, and the vast majority of urinary tract infections are related to indwelling catheters. At present, there are many antibacterial and anti-blocking methods on the surface of urinary catheters. These modification methods can enhance the antibacterial, lubricious and anti-fouling properties of the catheter surface, but the ideal surface modification method is especially aimed at solving the problem of long-term intubation patients. There is still no mature solution ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/14A61L29/08A61L29/16
CPCA61L29/14A61L29/145A61L29/085A61L29/16A61L29/146A61L2400/10C08L29/04
Inventor 林承雄黄正宇王耀程赵瑞芳张锦
Owner 广东省科学院生物与医学工程研究所
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