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Method for extracting nicotine from molecularly imprinted polymer

A technology of molecular imprinting and polymers, applied in chemical instruments and methods, other chemical processes, organic chemistry, etc., can solve the problems of high cost, low product purity, complicated steps, etc., achieve long service life, high selectivity, reduce Effect of Solvent Dosage

Active Publication Date: 2022-03-11
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned problems in the background technology, the present invention provides a method for extracting nicotine by molecularly imprinted polymers. The present invention artificially synthesizes molecularly imprinted polymers and uses the obtained molecularly imprinted polymers to prepare chromatographic columns to achieve Quickly and massively extract active ingredients (nicotine) from waste tobacco leaves, solving the problems of high cost, complicated steps, and low product purity in traditional methods of extracting active ingredients from waste tobacco leaves

Method used

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  • Method for extracting nicotine from molecularly imprinted polymer
  • Method for extracting nicotine from molecularly imprinted polymer
  • Method for extracting nicotine from molecularly imprinted polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1. Preparation of molecularly imprinted polymers (prepared by reverse suspension polymerization):

[0066] In an inert gas environment, 40.5 mg of nicotine template molecules, 43 mg of methacrylic acid (MAA), 36 mg of acrylic acid (AA), 385 mg of N,N-methylenebisacrylamide (BIS), 30 mg of ammonium persulfate ( APS) was dissolved in 10ml / 1ml of water / ethanol to obtain a dispersed phase; 10.3g of Span 80 was dissolved in 352ml of liquid paraffin to obtain a continuous phase; The dispersed phase was slowly added dropwise to the continuous phase to undergo a polymerization reaction. After 6 hours, the mixed solution was filtered to obtain a crude molecularly imprinted polymer, and the molecularly imprinted polymer was cleaned with a mixed solution containing acetic acid and methanol at a volume ratio of 1:9. Crude, the molecularly imprinted polymer MIP1 was obtained.

[0067] The difference between the preparation of non-imprinted polymer NIPs (Nonimprinted Polymers) and E...

Embodiment 2

[0101] In an inert gas environment, dissolve 40.5mg of nicotine template molecules, 129mg of MAA, 385mg of BIS, and 30mg of APS in 10ml / 1ml of water / ethanol to obtain a dispersed phase; dissolve 2.88g of Span 80 in 88ml of liquid In paraffin wax, the continuous phase is obtained; then at 70°C and 400rpm (rotational speed) mechanical stirring speed, the dispersed phase is slowly added dropwise to the continuous phase to undergo polymerization reaction, and after 6 hours, the mixed solution is filtered to obtain the molecularly imprinted polymer The crude product was washed with a mixed solution containing acetic acid and methanol at a volume ratio of 1:9 to obtain the molecularly imprinted polymer MIP2.

[0102] The adsorption and characterization results of molecularly imprinted polymers in this example, as well as the Flash chromatography column prepared by molecularly imprinted polymers and the performance test results are the same as those in Example 1, and will not be repea...

Embodiment 3

[0104] In an inert gas environment, dissolve 40.5mg of nicotine template molecules, 86mg of MAA, 385mg of BIS, and 30mg of APS in 10ml / 1ml of water / ethanol to obtain a dispersed phase; dissolve 2.88g of Span 80 in 88ml of liquid In paraffin wax, the continuous phase is obtained; then at 70°C and 400rpm (rotational speed) mechanical stirring speed, the dispersed phase is slowly added dropwise to the continuous phase to undergo polymerization reaction, and after 6 hours, the mixed solution is filtered to obtain the molecularly imprinted polymer The crude product was washed with a mixed solution containing acetic acid and methanol at a volume ratio of 1:9 to obtain the molecularly imprinted polymer MIP3.

[0105] The adsorption and characterization results of molecularly imprinted polymers in this example, as well as the Flash chromatography column prepared by molecularly imprinted polymers and the performance test results are the same as those in Example 1, and will not be repeat...

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Abstract

The invention provides a method for extracting nicotine from a molecularly imprinted polymer, which is characterized in that the molecularly imprinted polymer is prepared by a reversed-phase suspension polymerization method, the prepared molecularly imprinted polymer is used for preparing a chromatographic column, and a large amount of active ingredients (nicotine) are rapidly extracted from a tobacco crude extract by a chromatographic separation technology. The solvent dosage is effectively reduced, the extraction time is shortened, and the problems of high cost, complex steps, low product purity and the like of a traditional method for extracting the active ingredient nicotine from the waste tobacco leaves are solved. And the method has universality, can be used for extracting active components in other waste tobacco leaves only by replacing template molecules, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of separation and purification of nicotine, in particular to a method for extracting nicotine by a molecularly imprinted polymer. Background technique [0002] my country is a large tobacco-growing country, and tobacco income has become an indispensable aspect of my country's economic growth. However, a large amount of waste tobacco leaves are produced every year, and its disposal is a very troublesome problem. The nicotine contained in waste tobacco leaves has high application value and is widely used in the fields of fine chemicals, pharmaceuticals, organic synthesis, national defense industry and agriculture. Therefore, separating and extracting high-purity nicotine from waste tobacco leaves to turn waste into treasure and create economic value has become a research hotspot for those skilled in the art. [0003] Traditional nicotine extraction methods mainly include ion exchange, distillation, and extra...

Claims

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Application Information

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IPC IPC(8): C08F222/38C08F220/06C08J9/26C07D401/04B01J20/26B01J20/30C08L35/00
CPCC08F222/385C08J9/26C07D401/04B01J20/268C08J2201/0424C08J2335/00C08F220/06
Inventor 薛敏牛璠孟子晖张佳杰
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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