Medical metal material with modified film with photo-thermal characteristic on surface as well as preparation method and application of medical metal material

A metal material and modification technology, applied in metal material coating process, pharmaceutical formulation, medical science and other directions, can solve the problems of easy oxidation of non-precious metal nano-metal particles, reduction of nano-nickel cost, and inability to maintain photothermal effect for a long time.

Active Publication Date: 2022-03-08
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with traditional noble metal photothermal materials, the cost of nano-nickel constructed in the present invention is significantly reduced, and at the same

Method used

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  • Medical metal material with modified film with photo-thermal characteristic on surface as well as preparation method and application of medical metal material
  • Medical metal material with modified film with photo-thermal characteristic on surface as well as preparation method and application of medical metal material
  • Medical metal material with modified film with photo-thermal characteristic on surface as well as preparation method and application of medical metal material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A nickel-titanium (atomic ratio 1:1, purity 99.99%) alloy disc with a diameter of 10 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic waves in sequence, each time for 15 min. Using a solution containing 3mM nickel chloride, 1mM titanium chloride, and 6.5g / L urea (108mM) as the hydrothermal medium, the sample was hydrothermally treated under airtight conditions. The hydrothermal temperature was 120°C for 24h. The filling degree of the hydrothermal kettle is 35%. After the hydrothermal treatment, wash with a large amount of deionized water until the pH of the cleaning solution drops to 7. After the sample is dried, it is placed in a mixed atmosphere of argon / hydrogen for heat treatment, the flow rate of argon gas is 20 sccm, the flow rate of hydrogen gas is 5 sccm, the heat treatment temperature is 450°C, and the heat treatment time is 1h.

[0040] figure 1 It is a scanning electron microscope picture of the surface morphology of the ...

Embodiment 2

[0043] A nickel-titanium alloy disc with a diameter of 10mm and a thickness of 1mm (the atomic ratio of nickel to titanium is 1:1, and the purity is 99.99%) is cleaned with alcohol, deionized water, and ultrasonic in sequence, each time for 15 minutes. The sample was hydrothermally treated with a solution containing 3mM nickel chloride, 1mM titanium chloride, and 6.5g / L urea (108mM) as the hydrothermal medium. The hydrothermal temperature was 120°C for 24h. The filling degree of the hydrothermal kettle is 35%. After the hydrothermal treatment, wash with a large amount of deionized water until the pH of the cleaning solution drops to 7. After the sample was dried, it was placed in argon for heat treatment, the argon flow rate was 20 sccm, the heat treatment temperature was 450° C., and the heat treatment time was 1 h.

Embodiment 3

[0045] A nickel-titanium alloy disc with a diameter of 10mm and a thickness of 1mm (the atomic ratio of nickel to titanium is 1:1, and the purity is 99.99%) is cleaned with alcohol, deionized water, and ultrasonic in sequence, each time for 15 minutes. The sample was hydrothermally treated with a solution containing 6mM nickel chloride, 4mM titanium chloride, and 6.5g / L urea (108Mm) as the hydrothermal medium. The hydrothermal temperature was 120°C for 24h. The filling degree of the hydrothermal kettle is 35%. After the hydrothermal treatment, wash with a large amount of deionized water until the pH of the cleaning solution drops to 7. After the sample is dried, it is placed in a mixed atmosphere of argon / hydrogen for heat treatment, the flow rate of argon gas is 20 sccm, the flow rate of hydrogen gas is 5 sccm, the heat treatment temperature is 450°C, and the heat treatment time is 1h.

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Abstract

The invention relates to a medical metal material with a modified film with photo-thermal characteristics on the surface and a preparation method and application of the medical metal material. And the modified film is a nickel-titanium oxide TimNinO2m + n embedded with nano nickel. The nano nickel is a simple substance and is spherical, and the radius of the nano nickel is 2-20 nm; and the density of the nickel nanoparticles is 5-30 per square micron. The nickel-titanium oxide is of a sheet structure, the length and the width of a sheet layer are 0.5-2 microns, and the thickness of the sheet layer is 10-40 nm. In the preparation method, the nickel-titanium layered double hydroxide is firstly generated, and then the nickel-titanium oxide thin film inlaid with the elemental nickel is obtained through heating reduction. The cost of the constructed nano nickel is obviously reduced, and meanwhile the problems that non-noble metal nano metal particles are prone to being oxidized, and the photo-thermal effect cannot be kept for a long time are effectively solved; and the material also has good osteogenesis performance, improves the biological activity of medical metal, and is suitable for surface modification of hard tissue implantation instruments.

Description

technical field [0001] The invention relates to a medical metal surface modified film and its preparation method and application, specifically, it relates to a functional film with photothermal effect and osteogenic effect obtained by successively hydrothermal reaction and thermal reduction with medical metal as the substrate A material belongs to the technical field of surface modification of metal materials. Background technique [0002] Zinc, magnesium, iron, titanium and their alloys are widely used as hard tissue replacement materials due to their good mechanical properties and biocompatibility. Many current implant scenarios require materials with anticancer properties. For example, for bone cancer patients, after the affected area is replaced by an implant, the cancer may still recur, but if the implant itself has the ability to resist tumors, the possibility of recurrence will be reduced. In view of the sensitivity of tumor tissue to heat, photothermal therapy has ...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/54A61L31/02A61L31/16C23C26/00
CPCA61L27/06A61L27/54A61L31/022A61L31/16C23C26/00A61L2400/18
Inventor 王东辉郝雪青李宝娥梁春永
Owner HEBEI UNIV OF TECH
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