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Targeting peptide modified gold cluster iron oxide assembly material radiotherapy sensitizer

An iron oxide, gold cluster technology, applied in the intersection of nanomaterial chemistry and biochemistry, can solve the problems of limited concentration and ion release rate, insufficient to effectively suppress tumors, etc., achieve good tumor targeting and reduce X-ray dose , the effect of good theoretical basis and reference value

Active Publication Date: 2022-03-04
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since H 2 o 2 Concentration and ion release rates are limited, and these single cancer treatment strategies are often insufficient to effectively suppress tumors

Method used

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  • Targeting peptide modified gold cluster iron oxide assembly material radiotherapy sensitizer
  • Targeting peptide modified gold cluster iron oxide assembly material radiotherapy sensitizer
  • Targeting peptide modified gold cluster iron oxide assembly material radiotherapy sensitizer

Examples

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Effect test

Embodiment 1

[0019] Embodiment 1: Synthesis of gold cluster iron oxide assembly material of the present invention

[0020] (1) ferric chloride (FeCl 3 ·6H 2 O) and sodium oleate were dissolved in a mixed solvent consisting of ethanol, distilled water and n-hexane. The resulting solution was heated to 70°C and reacted for 4 hours. After the reaction was completed, the upper organic layer containing iron oleate complex was washed with distilled water in a separatory funnel. After washing, the iron oleate complex was obtained in the form of a waxy solid. The iron oleate complex and oleyl alcohol were then dissolved in diphenyl ether. The reaction mixture was heated to 220°C and reacted for 30 minutes. The resulting solution containing iron oxide nanocrystals was cooled to room temperature, and excess acetone was added to the solution to precipitate the nanocrystals. The nanocrystals are separated by centrifugation, producing iron oxide in the oil phase. At last. Disperse the prepared ...

Embodiment 2

[0024] Example 2: The gold cluster iron oxide assembly material of the present invention is used as a radiotherapy sensitizer

[0025] The gold cluster iron oxide assembly material of the present invention prepared in Example 1 was added to the culture medium and sonicated evenly, and the culture medium containing the material was used for cell cloning experiments, and different groups were treated with different doses of X-rays. see results Figure 5 , it can be seen that Au 4 -IO NP-cRGD+X-ray experimental group had the most significant cell necrosis.

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Abstract

The invention discloses a gold cluster iron oxide assembled material radiotherapy sensitizer, and belongs to the crossing field of nanomaterial chemistry and biochemistry. The preparation method comprises the following steps: assembling an Au4 cluster solution with ferric oxide in a cell culture solution, and then modifying the surface of the Au4 cluster solution with cyclic arginine-glycine-aspartic acid-phenylalanine cysteine (cRGD) peptide, so as to obtain Au4-IO NP-cRGD. The gold cluster iron oxide assembled material has strong green fluorescence at room temperature, has good dispersibility and tumor targeting, and can be used for high-quality cell imaging. The gold cluster iron oxide assembly material can be used as a radiotherapy sensitizer to achieve a radiotherapy sensitization effect, the X-ray dosage is reduced, and the high efficiency of killing tumor cells is achieved.

Description

technical field [0001] The invention belongs to the interdisciplinary field of nanomaterial chemistry and biochemistry, and specifically relates to a radiotherapy sensitizer for gold cluster assembly materials, in particular to a radiotherapy sensitizer for gold cluster iron oxide assembly materials modified by targeting peptides. Background technique [0002] Radiation therapy is used in more than half of cancer patients worldwide, and about 40 percent of cancer treatments involve radiation, sometimes in combination with other treatments. A major and pressing challenge for highly effective radiotherapy is how to maximize the killing of cancer cells while minimizing damage to surrounding healthy tissue. Among the many drugs that affect the efficacy of radiotherapy, gold-based nanomaterials are prime candidates for cancer therapy due to their high-quality attenuation coefficients and low cytotoxicity. At the same time, a series of therapeutic systems based on the Fenton resp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/64A61P35/00A61K49/00A61K33/26
CPCA61K41/0038A61K47/64A61K33/26A61P35/00A61K49/0019A61K49/0056A61K2300/00
Inventor 臧双全赵雪利华玥王朝阳
Owner ZHENGZHOU UNIV
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