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A kind of single-atom nanozyme and its preparation method and application

A nano-enzyme and atomic technology, applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of low single-atom loading and limit the application of single-atom nanozymes, and achieve simple and easy preparation methods and components. obtainable and controllable effects

Active Publication Date: 2022-05-10
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mass-selected soft deposition method and the atomic-level loading method both require specific expensive large-scale equipment and professional operators, and their single-atom loading is low
These two significant shortcomings limit its application in large-scale preparation of single-atom nanozymes.

Method used

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  • A kind of single-atom nanozyme and its preparation method and application
  • A kind of single-atom nanozyme and its preparation method and application
  • A kind of single-atom nanozyme and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: the preparation of Fe single atom nanozyme

[0053] 0.32g Fe(NO 3 ) 3 9H 2 O was dissolved in 20 mL of methanol to obtain 0.04 mol L -1 Ferric nitrate methanol solution (solution A); 11.9g Zn(NO 3 ) 2 ·6H 2 O was dissolved in 1000 mL of methanol to obtain 0.04 mol L -1 Zinc nitrate methanol solution (solution B); 20.1g methylimidazole was dissolved in 1000mL methanol to obtain 0.25mol L -1 Methanol solution of methylimidazole (Solution C). Put the above solution into figure 2 The feeding area of ​​the microfluidic reaction device shown.

[0054] First pass solution A and solution B into the transition chamber, stir and mix at a speed of 1000r / min, then pass the mixed metal ion solution and solution C into the microfluidic reaction chamber, and stir at a speed of 500r / min , keep the reaction at 60°C to obtain the conjugated supramolecule in the defect state, the reaction process is as follows image 3 shown. Set the flow rate of solution A to 0...

Embodiment 2

[0059] Embodiment 2: Preparation of Co single atom nanozyme

[0060] Prepare 0.125mol·L -1 Cobalt acetate N,N dimethylformamide solution (solution A) and 0.125mol·L -1 Zinc acetate N,N dimethylformamide solution (solution B) and 0.5mol L -1 1,1'-ferrocenecarboxylic acid N,N dimethylformamide solution (Solution C).

[0061] First pass solution A and solution B into the transition chamber, stir and mix at a speed of 1200r / min, then pass the mixed metal ion solution and solution C into the microfluidic reaction chamber, and stir at a speed of 800r / min , keep the reaction at 100°C to obtain the conjugated supramolecule in the defect state, the reaction process is as follows image 3 shown. Set the flow rate of solution A to 0 μL min -1 , 80 μL·min -1 , 160μL·min -1 , 240μL·min -1 , the four different flow rates correspond to the Co atom loadings from 0%, 4%, 8%, and 12% respectively; the corresponding solution B flow rate is set to 2000μL·min -1 , 1920μL·min -1 , 1840μL·...

Embodiment 3

[0066] Embodiment 3: the preparation of Mg single-atom nanozyme

[0067] Prepare 0.35mol·L -1 Magnesium chloride methanol solution (solution A), 0.2mol L -1 zinc chloride methanol solution (solution B) and 0.5mol L -1 4,4-bipyridine methanol solution (Solution C).

[0068] First pass solution A and solution B into the transition chamber, stir and mix at a speed of 800r / min, then pass the mixed metal ion solution and solution C into the microfluidic reaction chamber, and stir at a speed of 600r / min , keep the reaction at 60°C to obtain the conjugated supramolecule in the defect state, the reaction process is as follows image 3 shown. Set the flow rate of solution A to 0 μL min -1 , 80 μL·min -1 , 160μL·min -1 , 240μL·min -1 , four different flow rates correspond to the Mg atomic loads from 0%, 4%, 8%, and 12% respectively; the corresponding solution B flow rate is set to 2000μL·min -1 , 1920μL·min -1 , 1840μL·min -1 , 1760μL·min -1 ; The flow rate of solution C was...

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Abstract

The invention discloses a single-atom nanozyme and its preparation method and application. The single-atom nanozyme is formed by coordinating doped metal ions and host metal ions with organic monomers in a microfluidic reaction device to form a defect state. Conjugated supramolecules are obtained by pyrolyzing the conjugated supramolecules in the defect state under an inert atmosphere. Organic monomers coordinate to form non-metallic heteroatom-doped carriers, and metal ions interact with non-metallic heteroatoms. A partial reduction reaction occurs and exists in the form of a single atom encapsulated in a porous hyperconjugated carbon support. The preparation method provided by the invention is applicable to the preparation of single-atom bodies of various metals, the preparation method is simple and easy, and the prepared single-atom nanozyme has atomic-level dispersed active sites. Experimental results show that the single-atom nanozyme prepared by the invention has good peroxidase-like activity, and has broad application prospects in the field of rapid detection of cysteine, ascorbic acid and glutathione.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a single-atom nanozyme and its preparation method and application. Background technique [0002] At present, the catalytic effect of nanomaterials is closely related to the particle size of catalytic active sites. A large number of existing studies have shown that the smaller the size of nanozymes, the more significant their catalytic activity. In conventional nanoparticle-level catalytic materials, only the atoms on the outermost atomic layer have catalytic activity; and most of the atoms on it are in the interior, and almost all of them have no significant impact on the catalytic effect of nanomaterials. . Single-atom biomimetic enzyme refers to the material whose catalytic active site is a single metal atom. Its extremely small dispersion characteristics and extremely high catalytic activity (its atoms are all surface atoms, no internal atoms), greatly improve th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J23/80B01J23/755B01J23/75B01J23/745B01J23/72B01J23/60B01J23/46B01J23/22B01J23/18B01J23/06B01J21/10B22F9/30B22F1/07G01N21/31G01N33/68B82Y40/00B82Y30/00
CPCB01J23/745B01J23/80B01J23/75B01J21/10B01J23/06B01J23/18B01J23/468B01J23/60B01J23/22B01J23/72B01J23/755B22F9/30G01N21/31G01N33/6815G01N33/68B82Y40/00B82Y30/00
Inventor 吴红姣林鹏程刘骏区文滔王梓安
Owner GUANGDONG UNIV OF TECH
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