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Alginate encapsulated bacterial cellulose composite photo-thermal antibacterial medical dressing and preparation method thereof

A technology of bacterial cellulose and alginate, which is applied in the field of medical composite materials, can solve the problems of cytotoxicity, achieve low cost, good application prospects, and promote the effect of transmission and release rate

Pending Publication Date: 2022-02-01
THE PEOPLES HOSPITAL SHAANXI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some studies have shown that nanoparticles are easily phagocytized and aggregated in cells, resulting in cytotoxicity.

Method used

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  • Alginate encapsulated bacterial cellulose composite photo-thermal antibacterial medical dressing and preparation method thereof
  • Alginate encapsulated bacterial cellulose composite photo-thermal antibacterial medical dressing and preparation method thereof

Examples

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preparation example Construction

[0035] The preparation method of a kind of alginate-encapsulated bacterial cellulose composite photothermal antibacterial medical dressing provided by the invention comprises the following steps:

[0036] Step 1, prepare bacterial cellulose solution:

[0037] Breaking the bacterial cellulose omentum by mechanical homogenization method to obtain bacterial cellulose homogenate;

[0038] The bacterial cellulose homogenate is centrifuged to remove water, soaked and purified in a sodium hydroxide solution, washed to neutrality, suction filtered and freeze-dried to obtain pretreated bacterial cellulose;

[0039] The bacterial cellulose is dissolved in the ionic liquid to obtain a bacterial cellulose solution with a mass concentration of 0.5-3%.

[0040] Wherein, the ionic liquid is an ionic solvent or a mixed solvent composed of an ionic solvent and a co-solvent;

[0041] Ionic liquids include 1-ethyl-3-methylimidazolium chloride, 1-allyl-3-methylimidazolium chloride, 1-butyl-3-me...

Embodiment 1

[0056] 1) Preparation of bacterial cellulose solution:

[0057] 1 g of bacterial cellulose was dissolved in 1 L of deionized water, and homogenized in a high-pressure homogenizer for 20 minutes, and the homogenization pressure was set at 80 MPa to obtain bacterial cellulose homogenate.

[0058] Centrifuge the homogenized bacterial cellulose solution in a high-speed centrifuge at 10,000 rpm for 10 minutes to obtain wet bacterial cellulose, and dissolve the obtained wet bacterial cellulose in a sodium hydroxide solution with a pH value of 12 After immersing in medium for 24 hours, it was filtered and washed to neutrality, and the obtained purified bacterial cellulose was freeze-dried for future use.

[0059] The obtained dry bacterial cellulose was dissolved in 1-ethyl-3-methylimidazolium chloride salt ionic liquid solvent to prepare a bacterial cellulose ionic liquid solution with a mass fraction of 0.5%.

[0060] 2) Preparation of photothermal antibacterial nanoparticle dispe...

Embodiment 2

[0072] 1) Preparation of bacterial cellulose solution:

[0073] 1 g of bacterial cellulose was dissolved in 1 L of deionized water, and homogenized in a high-pressure homogenizer for 20 minutes, and the homogenization pressure was set at 60 MPa to obtain bacterial cellulose homogenate.

[0074] Centrifuge the homogenized bacterial cellulose solution in a high-speed centrifuge at 8000 rpm for 10 minutes to obtain wet bacterial cellulose, and dissolve the obtained wet bacterial cellulose in a sodium hydroxide solution with a pH value of 12 After immersing in medium for 24 hours, it was filtered and washed to neutrality, and the obtained purified bacterial cellulose was freeze-dried for future use.

[0075] The obtained dry bacterial cellulose was dissolved in 1-butyl-3-methylimidazolium chloride salt ionic liquid to prepare a bacterial cellulose ionic liquid solution with a mass fraction of 2%.

[0076] 2) Preparation of photothermal antibacterial nanoparticle dispersion:

[0...

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Abstract

The invention discloses an alginate encapsulated bacterial cellulose composite photo-thermal antibacterial medical dressing and a preparation method thereof. The preparation method comprises the steps that a bacterial cellulose solution, a photo-thermal antibacterial nano particle dispersion liquid, an electrostatic spinning composite spinning solution and an alginate outer layer coating structure are prepared, and the prepared composite photo-thermal antibacterial medical dressing is of an inner-layer structure and an outer-layer structure; the inner layer is a bacterial cellulose / zinc oxide / copper sulfide composite porous membrane prepared by electrostatic spinning, and the outer layer is an alginate encapsulation layer constructed by impregnation and cationic crosslinking. The composite medical dressing has biocompatibility and moisture absorption and water retention of bacterial cellulose and alginic acid materials, excellent mechanical properties, antibacterial characteristics, photo-thermal response performance and air permeability and oxygen permeability of the dressing, and free exchange of antibacterial ions and electrolyte in body fluid is achieved. Moreover, the preparation process is controllable, the antibacterial effect is efficient and lasting, meanwhile, a photo-thermal effect is achieved, and the medical dressing has an important application prospect in the aspects of tissue repair, surgical incision treatment and burn wound treatment as a medical dressing.

Description

technical field [0001] The invention belongs to the field of medical composite materials, in particular to an alginate-encapsulated bacterial cellulose composite photothermal antibacterial medical dressing and a preparation method thereof. Background technique [0002] The skin is the first line of defense of the human body, and it is also the most vulnerable part of the human body. The healing of skin wounds is a complex and dynamic process, and infection is one of the most common factors leading to delayed wound healing. Wound dressings have unique advantages such as anti-inflammatory and hemostasis, wound moisturizing, and accelerated healing, and have unique advantages such as small side effects, and are widely used in many scenarios including surgical wounds. An ideal wound dressing needs to meet the following characteristics at the same time: porous structure, good mechanical properties, high water holding capacity, non-toxic, good tissue compatibility and antibacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/03D01F2/00D01F1/10A61K41/00A61L15/18A61L15/28A61L15/42A61L15/46A61P31/04D06M101/06
CPCD06M15/03D01F2/00D01F1/103A61L15/28A61L15/18A61L15/425A61L15/42A61L15/46A61K41/0052A61P31/04A61L2300/404A61L2300/232A61L2300/102A61L2400/12A61L2300/602A61L2300/412D06M2101/06C08L5/04C08L1/02
Inventor 党运芝王青于娇赵淑红
Owner THE PEOPLES HOSPITAL SHAANXI PROV
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