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Preparation method of nano-mesoporous composite flexible membrane material for promoting blood vessel formation

A nano-mesoporous and flexible membrane technology, which can be used in pharmaceutical formulations, medical science, non-woven fabrics, etc., can solve problems that cannot meet clinical needs, and achieve good effects of promoting vascular performance, promoting osseointegration, and promoting osteogenic differentiation

Active Publication Date: 2022-01-21
广东省华源康泰生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Autologous bone grafting is the gold standard for bone implantation. However, when the bone defect is large, autologous bone grafting cannot meet the clinical needs, and implant materials with good osteogenic activity / osteogenic activity are still needed for filling and repairing.

Method used

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  • Preparation method of nano-mesoporous composite flexible membrane material for promoting blood vessel formation
  • Preparation method of nano-mesoporous composite flexible membrane material for promoting blood vessel formation
  • Preparation method of nano-mesoporous composite flexible membrane material for promoting blood vessel formation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment provides a method for preparing a nano-mesoporous composite flexible membrane material that promotes blood vessels, including the following steps:

[0035] S1), preparation of nanometer mesoporous silicon-calcium-based active particles

[0036] S101), dissolve 2 g of emulsifier cetyltrimethylammonium bromide with 100 mL of deionized water, stir for 20 min, and make a solution for later use;

[0037] S102), adding a certain volume of 1mol / L ammonia solution to the solution in step S101), stirring and dissolving for 10 minutes, and adjusting the pH value to reach 8.5;

[0038] S103), adding 22 mL of ethyl acetate to the solution in step S102), stirring and dissolving for 30 min;

[0039] S104), adding 8 mL of tetraethyl orthosilicate to the solution in step S103), stirring and dissolving for 30 min;

[0040] S105), adding 6 g of calcium nitrate and 0.08 g of strontium nitrate to the solution in step S104), stirring and dissolving for 3 h;

[0041] S106)...

Embodiment 2

[0051] This embodiment provides a method for preparing a nano-mesoporous composite flexible membrane material that promotes blood vessels, including the following steps:

[0052] S1), preparation of nanometer mesoporous silicon-calcium-based active particles

[0053] S101), dissolve 2.6g of emulsifier cetyltrimethylammonium bromide with 150mL of deionized water, stir for 20min, and prepare a solution for later use;

[0054] S102), adding a certain volume of 1mol / L ammonia solution to the solution in step S101), stirring and dissolving for 10 minutes, and adjusting the pH value to reach 8.0;

[0055] S103), adding 30 mL volume of ethyl acetate to the solution in step S102), stirring and dissolving for 30 min;

[0056] S104), adding 12 mL volume of tetraethyl orthosilicate to the solution in step S103), stirring and dissolving for 30 min;

[0057] S105), adding 10 g of calcium nitrate and 0.1 g of strontium nitrate to the solution in step S104), stirring and dissolving for 4 h...

Embodiment 3

[0068] Performance Testing

[0069] In this embodiment, the flexible membrane material prepared in Example 1 is used as the research object, wherein, figure 1 It is the topography figure of the nanometer mesoporous silicon-calcium-based active particle in the preparation of Example 1, as can be seen from the figure, the size of the active particle prepared is about 160nm, and the surface has more mesoporous existence, and this structure can be It plays a very good role as a carrier for loading drugs and nutritional factors, and enhances the activity of the bulk material.

[0070] figure 2 The fluorescence map of the blood vessel formation of the nanometer mesoporous silicon-calcium-based active particles / polyvinylidene fluoride composite flexible membrane material prepared in Example 2, as can be seen from the figure, compared with the blank group, the experimental group has a stronger ability to promote blood vessels .

[0071] Table 1 is the aperture, pore volume, and ma...

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Abstract

The invention provides a preparation method of a nano-mesoporous composite flexible membrane material for promoting blood vessel formation. The method comprises preparation of nano-mesoporous silicon-calcium-based active particles and preparation of a nano-mesoporous silicon-calcium-based active particle / polyvinylidene fluoride composite flexible membrane material. The nano-mesoporous silicon-calcium-based active particle / polyvinylidene fluoride composite flexible membrane material is uniform in chemical components. The nano-mesoporous silicon-calcium-based active particles are large in specific surface area, large in mesoporous aperture and uniform in size at the nanoscale. The nano-mesoporous silicon-calcium-based active particle / polyvinylidene fluoride composite membrane belongs to a flexible material. The nano-mesoporous silicon-calcium-based active particle / polyvinylidene fluoride composite flexible membrane material has good vascular formation promoting performance, and can promote osteogenic differentiation of cells and stimulate expression of angiogenesis related factors to promote osseointegration after being implanted into a defect part.

Description

technical field [0001] The invention relates to the technical field of bioflexible materials, in particular to a method for preparing a flexible membrane material composed of nanometer mesoporous silicon-calcium-based active particles / polyvinylidene fluoride that facilitates blood vessels. Background technique [0002] Due to the increase of bone damage caused by traffic accidents and malignant tumors, there are a large number of cases of bone defect repair in clinical practice. Autologous bone grafting is the gold standard for bone implantation. However, when the bone defect is large, autologous bone grafting cannot meet the clinical needs, and it is still necessary to use implant materials with good osteogenic activity / osteogenic activity for filling and repairing. [0003] In the process of defect repair, the role of the periosteum is often ignored. The growing periosteum and osteocytes will participate in the growth of the bone, because there are nerves and blood vessels...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/02A61L27/50A61L27/56D04H1/4318D04H1/728
CPCA61L27/025A61L27/16A61L27/56A61L27/50D04H1/728D04H1/4318A61L2430/02A61L2400/12C08L27/16
Inventor 张芳郑裕民
Owner 广东省华源康泰生物科技有限责任公司
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