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Application of gambogic acid in preparation of medicine for preventing or treating kidney ischemia-reperfusion injury

A technology of reperfusion injury and gambogic acid, applied in the field of medicine, can solve the problems of lack of renal IRI, achieve the effects of improving renal IRI, enhancing mitophagy, and improving renal dysfunction

Active Publication Date: 2021-12-31
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Renal IRI is very common in clinical practice, but there is still a lack of clinically effective drugs for the treatment of renal IRI

Method used

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  • Application of gambogic acid in preparation of medicine for preventing or treating kidney ischemia-reperfusion injury
  • Application of gambogic acid in preparation of medicine for preventing or treating kidney ischemia-reperfusion injury
  • Application of gambogic acid in preparation of medicine for preventing or treating kidney ischemia-reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The injection prepared by gambogic acid freeze-dried powder injection can be used to administer the donor through intravenous injection before the kidney transplant operation. Note, the second intravenous bolus is given to the donor 2 to 1 hour before the transplanted organ is obtained. The effective dose of administration is generally 4-40mg / m each time 2 , which can be adjusted according to the donor's weight, age, physical condition and other factors, where the unit is mg / m 2 Indicates the amount of drug used in milligrams per square meter of body surface area of ​​the donor. For example, the effective dose of each intravenous injection is 14-16 mg / m 2 , used to prevent renal ischemia-reperfusion injury in the donor, or to repair the renal ischemia-reperfusion injury that has occurred.

Embodiment 2

[0034] The injection prepared by gambogic acid freeze-dried powder injection is administered to the donor through intravenous injection before the kidney transplant operation, and the administration time is the first intravenous injection to the donor 14 to 12 hours before the harvest of the transplanted organ 2-1 hours before harvesting the transplanted organ, give the donor a second intravenous bolus injection. The effective dose for each intravenous injection can be 8-10 mg / m 2 , used to prevent renal ischemia-reperfusion injury in the donor, or to repair the renal ischemia-reperfusion injury that has occurred.

Embodiment 3

[0036] The injection prepared by gambogic acid freeze-dried powder injection was administered to the donor through intravenous injection before the kidney transplant operation. A second intravenous injection was given to the donor 1 hour before harvesting the transplanted organ. Select the effective dose of each intravenous injection as 11-13mg / m 2 , used to prevent renal ischemia-reperfusion injury in the donor, or to repair the renal ischemia-reperfusion injury that has occurred.

[0037] In order to confirm the excellent curative effect of the gambogic acid of the present invention in the prevention or treatment of renal ischemia-reperfusion injury, the results obtained in various basic pharmacological studies will be further introduced below. In the experiment, commercially available gambogic acid powder was used and dissolved to make gambogic acid injection. For the convenience of description, the abbreviations of concepts, meanings or names in various pharmacology are ...

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Abstract

The invention discloses application of gambogic acid in preparation of a medicine for preventing or treating kidney ischemia-reperfusion injury. According to the application, animal experiments and cell experiments are carried out on gambogic acid which is an extract of traditional Chinese medicine gamboge, it is found that a certain dosage of gambogic acid can remarkably relieve mouse kidney ischemia-reperfusion injury, the protection effect is mainly achieved by enhancing mitochondrial autophagy, and important technical support is provided for preventing or treating kidney IRI. Clinically, an injection can be prepared from the gambogic acid freeze-dried powder injection, the injection is administrated through intravenous injection, the administration time is at least one time of intravenous injection on a donor within 24 hours before a transplanted organ is obtained, and the effective dose of the intravenous injection is 4-40 mg / m < 2 > each time. The new application of the gambogic acid in kidney protection and repair is proved, and a new selection scheme or thought is provided for medical researchers to clinically explore and treat ischemia-reperfusion injury of heart, liver, lung and other organs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and mainly relates to a new pharmaceutical application of gambogic acid, in particular to the application of gambogic acid as a medicine for preventing or treating renal ischemia-reperfusion injury. Background technique [0002] Ischemia-reperfusion injury (ischemia-reperfusion injury, IRI) is one of the most common pathogenic factors of acute kidney injury, commonly seen in patients with kidney transplantation, cardiac surgery, trauma and shock. For example, kidney transplantation is currently the most effective treatment for end-stage renal disease. However, the process of kidney transplantation includes the removal of the kidney from the donor, the preservation of the kidney in vitro, and the vascular reconstruction and blood reperfusion of the donor kidney implanted into the recipient. Ischemic injury, cold ischemic injury during cold storage, and reperfusion injury after restoration of blo...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/19A61P13/12A61P9/10A61K36/38
CPCA61K31/352A61K9/19A61K9/0019A61P13/12A61P9/10A61K36/38
Inventor 陈刚李亚坤韩珍旖
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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