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Surgical repair patch as well as preparation method and application thereof

A technology of surgery and patch, applied in medical science, prosthesis, etc., can solve the problems of fast degradation of repair patch, tissue invasion, poor repair effect, etc., to maintain the properties of collagen itself, mild cross-linking conditions, prevent destroyed effect

Pending Publication Date: 2021-12-24
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finally, it needs to have good degradation resistance. It takes time and process for wound healing and tissue repair. If the repair patch used is degraded in advance, it will lead to incomplete wound repair, tissue invasion and other adverse clinical effects.
[0003] The surgical repair patch produced by the existing technology cannot take into account the three aspects of product thickness controllability, product degradation cycle meeting clinical needs, product can be completely degraded and absorbed by the body, the usual practice is: in order to improve the degradation performance of the product Increase the process steps of chemical cross-linking such as glutaraldehyde, and the repair patch produced by the cross-linking process cannot be completely degraded and absorbed by the body; in order to control the thickness of the product and optimize the biocompatibility of the product, collagen optimization will be used Recombination process, the repair patch produced by this process degrades quickly and cannot meet clinical needs, and the double helix microstructure of collagen is destroyed, resulting in poor repair effect
In order to retain the natural structure of collagen, the raw material treatment method of manual scraping is used in the prior art, the purpose is to only remove the useless tissue on the surface, without destroying the natural structure of the dermis, but the efficiency of this process is relatively low, and the thickness of the film after scraping is not enough. control, thereby affecting production efficiency and product quality

Method used

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  • Surgical repair patch as well as preparation method and application thereof
  • Surgical repair patch as well as preparation method and application thereof
  • Surgical repair patch as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Material selection: select fresh cowhide after isolation, try to avoid contact with pollutants, and freeze immediately after collection;

[0061] (2) Pretreatment: thaw and fully clean the cowhide after separation, use a hair removal machine and a skinning machine to remove the fat on the inner surface of the cowhide and the mane on the outer layer, etc., which are not suitable for processing. part, and then rinse the remaining part with purified water to obtain the pretreated product. into a range to increase the scope of use and ease of operation);

[0062] (3) Tween80 solution treatment: the product obtained after pretreatment is placed in a Tween80 solution with a mass concentration of 1%, soaked for 12 hours at 0-20°C, and then washed with purified water;

[0063] (4) NaOH solution treatment: the product obtained in step (3) is placed in a NaOH solution with a mass concentration of 2%, soaked at 10°C for 4 hours, and then washed with purified water;

[0064] ...

Embodiment 2

[0069] (1) Material selection: select fresh sheepskin after isolation, try to avoid contact with pollutants, and freeze and store immediately after collection;

[0070] (2) Pretreatment: thaw and fully clean the cowhide after separation, use a hair removal machine and a skinning machine to remove the fat on the inner surface of the cowhide and the mane on the outer layer, etc., which are not suitable for processing. part, and then rinse the remaining part with purified water to obtain a pretreated product with a thickness of 0.6-2mm;

[0071] (3) TritonX-100 solution treatment: place the pretreated product in a TritonX-100 solution with a mass concentration of 5%, soak it for 24 hours at 10-30°C, and then wash it with purified water;

[0072] (4) KOH solution treatment: the product obtained in step (3) is placed in a KOH solution with a mass concentration of 5%, soaked at 15°C for 2 hours, and then washed with purified water;

[0073] (5) Phosphate buffer treatment: place the...

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Abstract

The invention discloses a surgical repair patch as well as a preparation method and application thereof. The preparation method of the surgical repair patch comprises the following steps of taking in-vitro raw material skin, removing hair tissues from the outer surface layer, and removing an epidermal layer and a subcutaneous tissue layer by a mechanical cutting method to obtain a corium layer; soaking the corium layer in a nonionic surfactant solution for degreasing; then, performing soaking treatment in an alkali solution for decellularization; next, performing soaking treatment in an equilibrium buffer solution; and finally, carrying out thermal crosslinking to obtain the surgical repair patch. The preparation method can be applied to preparation of surgical repair patches used in the fields of stomatology, neurosurgery, abdominal wall surgery or gynecology. By adjusting the blade on machinery, the thickness of the corium layer is controlled; and meanwhile, a thermal crosslinking method is adopted, so that the interior of collagen molecules is self-dehydrated to form hydrogen bonds, the stability of the repairing film is improved, and the degradation time is further prolonged.

Description

technical field [0001] The invention relates to a surgical repair patch, a preparation method and application thereof, and belongs to the field of regenerative medical materials. Background technique [0002] Surgical repair patch is mainly used for wound protection after surgery. It has two main functions. One is to isolate the wound or tissue defect from the surrounding tissue through the function of physical barrier and form a certain tissue living space to prevent the surrounding tissue from The tissue invades the defect area; the second is to promote the healing of the surgical wound and guide the repair of the defective tissue. To achieve the above goals, the surgical repair patch should have the following characteristics: First, it needs to have good biocompatibility, the degradation process and products do not hinder the healing of the wound, and the degradation products can be absorbed by the body without causing obvious irritation Second, it must have a certain de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/58
CPCA61L27/362A61L27/3687A61L27/3691A61L27/58
Inventor 郭松王彬刘启省姜洪磊
Owner YANTAI ZHENGHAI BIO TECH
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