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A preparation method of a new type of microgel bone powder for tissue repair after osteoma surgery

A microgel bone powder, tissue repair technology, applied in tissue regeneration, prosthesis, medical science and other directions, can solve problems such as failure and residual treatment

Active Publication Date: 2022-05-17
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After surgical intervention in tumorous bone defects, there may be residual tumor cells that may lead to treatment failure

Method used

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  • A preparation method of a new type of microgel bone powder for tissue repair after osteoma surgery
  • A preparation method of a new type of microgel bone powder for tissue repair after osteoma surgery
  • A preparation method of a new type of microgel bone powder for tissue repair after osteoma surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of a new type of microgel bone powder that can be used for tissue repair after osteoma surgery

[0029] Step 1, preparation of mesoporous bioactive glass nanospheres.

[0030] Under magnetic stirring at 500 rpm, mix 240 ml of 0.02 g / ml cetyltrimethylammonium bromide solution, 160 ml of absolute ethanol and 3 ml of 25% ammonia water, and add 7.11 g of nitric acid tetrahydrate to it Calcium, 1.30 g of cerium nitrate hexahydrate and 0.52 g of sodium selenite were fully dissolved, and then 1.4 mL of triethyl phosphate and 14 mL of tetraethyl silicate were added to it. After washing with ultrapure water three times alternately, the precipitate was kept in an oven at 60 °C for 24 h, and then the dried precipitate was calcined in a muffle furnace at 600 °C for 3 h to obtain mesoporous particles rich in selenium and cerium. Bioactive glass nanospheres.

[0031] The pore size analysis of mesoporous bioactive glass nanospheres shows that the pore size is 2...

Embodiment 2

[0034] Example 2 Preparation of a new type of microgel bone powder that can be used for tissue repair after osteoma surgery

[0035] Step 1, preparation of mesoporous bioactive glass nanospheres.

[0036] Under magnetic stirring at 500 rpm, mix 240 ml of 0.02 g / ml cetyltrimethylammonium bromide solution, 160 ml of absolute ethanol and 3 ml of 25% ammonia water, and add 7.10 g of nitric acid tetrahydrate to it Calcium, 2.60 g of cerium nitrate hexahydrate and 0.52 g of sodium selenite were fully dissolved, and then 0.80 mL of triethyl phosphate and 14 mL of tetraethyl silicate were added to it. After washing with ultrapure water three times alternately, the precipitate was kept in an oven at 60 °C for 24 h, and then the dried precipitate was calcined in a muffle furnace at 600 °C for 3 h to obtain mesoporous particles rich in selenium and cerium. The physical and chemical properties of the bioactive glass nanospheres are similar to those of the mesoporous bioactive glass nanos...

Embodiment 3

[0039] Example 3 Preparation of a new type of microgel bone powder that can be used for tissue repair after osteoma surgery

[0040] Step 1, preparation of mesoporous bioactive glass nanospheres.

[0041] Under magnetic stirring at 500 rpm, mix 240 ml of 0.02 g / ml cetyltrimethylammonium bromide solution, 160 ml of absolute ethanol and 3 ml of 25% ammonia water, and add 7.10 g of nitric acid tetrahydrate to it Calcium, 0.65 g of cerium nitrate hexahydrate and 0.52 g of sodium selenite were fully dissolved, and then 0.7 mL of triethyl phosphate and 7 mL of tetraethyl silicate were added to it. After washing with ultrapure water three times alternately, the precipitate was kept in an oven at 60 °C for 24 h, and then the dried precipitate was calcined in a muffle furnace at 600 °C for 3 h to obtain mesoporous particles rich in selenium and cerium. The physical and chemical properties of the bioactive glass nanospheres are similar to those of the mesoporous bioactive glass nanosph...

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Abstract

The invention discloses a preparation method of a new type of microgel bone powder that can be used for tissue repair after osteoma surgery. First, bioactive glass nanoparticles rich in cerium and selenium are prepared by using a sol-gel method, and then the cerium, selenium, and The dispersion of selenium bioactive glass nanoparticles, human-like collagen solution and sodium alginate solution are mixed evenly to obtain an organic / inorganic mixed solution, and finally, the mixed solution is dropped into a calcium chloride solution to form a gel by using an electrospinning apparatus The microspheres were collected by centrifugation, washed with ultrapure water, and then freeze-dried and Co-60 sterilized to prepare the final new microgel bone powder. The new type of microgel bone powder prepared by the invention can promote the growth of bone cells and inhibit the growth of cancer cells, and completely fit the shape of bone tissue defects, can effectively realize the repair of tissue defects after osteoma surgery, and can also be used as bone cement or artificial bone prefabrication Ideal material for stents with good application potential.

Description

technical field [0001] The invention relates to a preparation method of a novel microgel bone powder used for tissue repair after osteoma surgery, and belongs to the field of medical repair materials. Background technique [0002] Bone tumors are tumors that occur in human bones or its accessory tissues. There are differences between benign and malignant. Malignant bone tumors are commonly referred to as bone cancer. Benign bone tumors are easy to cure and have good prognosis, while malignant bone tumors develop rapidly, have poor prognosis and high mortality. Benign bone tumors often turn into bone cancer. The treatment of bone tumors is mainly based on local curettage and bone grafting or resection. After surgical intervention in tumorous bone defects, there may be residual tumor cells, resulting in treatment failure. Therefore, for the implantation of bone repair filling materials for bone tissue defects caused by surgical removal of bone tumors, it must not only have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/20A61L27/22A61L27/54A61L27/50A61L27/04A61L27/02
CPCA61L27/10A61L27/20A61L27/227A61L27/54A61L27/50A61L27/047A61L27/025A61L2430/02A61L2300/102A61L2300/10A61L2300/416A61L2300/412C08L5/04C08L89/00
Inventor 惠俊峰樊妙琳李娜范代娣郑晓燕
Owner NORTHWEST UNIV
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