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Thiamine nitrate sustained-release microcapsule and preparation method thereof

A technology of slow-release microcapsules and thiamine nitrate, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations. uniform effect

Pending Publication Date: 2021-12-03
HUAZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these granular or sheet-like thiamine nitrates are released quickly in the body, failing to achieve the purpose of continuous administration and continuous treatment

Method used

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  • Thiamine nitrate sustained-release microcapsule and preparation method thereof
  • Thiamine nitrate sustained-release microcapsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of described thiamine nitrate slow-release microcapsules, comprises the steps:

[0031] S1. Preparation of wall material: Wash the coconut shell, crush and sieve it, then place it in a vacuum environment for carbonization to obtain coconut shell carbon ash, then dissolve the coconut shell carbon ash in water to obtain coconut shell carbon Gray aqueous solution, then add plant hydrolytic enzyme powder to described coconut shell carbon ash aqueous solution to carry out enzymolysis reaction, the addition amount of described plant hydrolytic enzyme powder is 0.05% (W / V), the temperature of described enzymolysis reaction is 25 ℃ , the time is 1h, the modified coconut shell solution is obtained, and finally polyethyleneimine is added to the above-mentioned modified coconut shell solution to obtain a wall material mixture, the modified coconut shell and polyethylene imine in the wall material mixture The mass ratio of amine is 1:1;

[0032] S2. Preparat...

Embodiment 2

[0035] The preparation method of described thiamine nitrate slow-release microcapsules, comprises the steps:

[0036]S1. Preparation of wall material: Wash the coconut shell, crush and sieve it, then place it in a vacuum environment for carbonization to obtain coconut shell carbon ash, then dissolve the coconut shell carbon ash in water to obtain coconut shell carbon Gray aqueous solution, then add plant hydrolytic enzyme powder to described coconut shell carbon ash aqueous solution to carry out enzymolysis reaction, the addition amount of described plant hydrolytic enzyme powder is 0.08% (W / V), the temperature of described enzymolysis reaction is 35 ℃ , the time is 1.5h, and the modified coconut shell solution is prepared, and finally polyethyleneimine is added to the above-mentioned modified coconut shell solution to obtain a wall material mixture, and the modified coconut shell and polyethylene in the wall material mixture are The mass ratio of imine is 3:1;

[0037] S2. P...

Embodiment 3

[0040] The preparation method of described thiamine nitrate slow-release microcapsules, comprises the steps:

[0041] S1. Preparation of wall material: Wash the coconut shell, crush and sieve it, then place it in a vacuum environment for carbonization to obtain coconut shell carbon ash, then dissolve the coconut shell carbon ash in water to obtain coconut shell carbon Gray aqueous solution, then add plant hydrolytic enzyme powder to described coconut shell carbon ash aqueous solution to carry out enzymolysis reaction, the addition amount of described plant hydrolytic enzyme powder is 0.1% (W / V), the temperature of described enzymolysis reaction is 40 ℃ , the time is 2h, and the modified coconut shell solution is prepared, and finally polyethyleneimine is added to the above-mentioned modified coconut shell solution to obtain a wall material mixture, and the modified coconut shell and polyethyleneimine in the wall material mixture are The mass ratio of amine is 5:1;

[0042] S2...

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Abstract

The present invention discloses a thiamine nitrate sustained-release microcapsule which comprises a wall material and a core material, the wall material comprises modified coconut shells and polyethyleneimine, and the core material is thiamine nitrate; and the core material is wrapped in the wall material. Waste coconut shells are subjected to high-temperature carbonization, plant hydrolase hydrolysis and other treatments to obtain modified coconut shells, then the modified coconut shells and polyethyleneimine are subjected to a cross-linking reaction to obtain the wall material, through the synergistic effect of the modified coconut shells and polyethyleneimine, the slow-release effect of the thiamine nitrate slow-release microcapsule is greatly enhanced, meanwhile, waste coconut shells are utilized, waste is turned into wealth, resources are saved, and the pressure of environmental protection is relieved; and the polyethyleneimine contains a large number of primary amino groups and secondary amino groups with positive charges, so that the prepared thiamine nitrate sustained-release microcapsules are uniformly dispersed and are not easy to bond due to the action of electrostatic repulsion between the surfaces.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical preparations, and in particular relates to a thiamine nitrate slow-release microcapsule and a preparation method thereof. Background technique [0002] Vitamin B1 is a compound composed of a pyrimidine ring and a thiazole ring. Because the molecule contains sulfur and amines, it is named thiamine. General medical vitamin B1 is the hydrochloride (thiamine hydrochloride) of chemically synthesized vitamin B1, and thiamine nitrate (thiamine nitrate) is the nitrate of vitamin B1, which is often used as nutritional supplements, food additives and multivitamin preparations, etc. . Because it is more stable than thiamine hydrochloride in water, thiamine nitrate is more suitable for the preparation of powder, tablet medicine, thiamine nitrate, its raw material is white or off-white powder, slightly has special odor; this product is slightly soluble in water (1g / 35ml), slightly solu...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/51A61K47/46A61K47/32A61P1/14A61P3/02A61P25/00
CPCA61K9/5063A61K9/5026A61K9/5089A61K31/51A61P3/02A61P1/14A61P25/00
Inventor 罗浩付林詹顺昌魏旭丽胡惠珊王霜
Owner HUAZHONG PHARMA
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