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Application of a kind of glycerol glucoside in the preparation of oral care products

A glucoside and oral care technology, which is applied in the application field of glycerol glucoside in the preparation of oral care products, can solve the problems of reduced sensitivity of dental nerves, inability to feel sensitive stimuli, weakening, etc., to reduce the frequency of action potential release and Action potential amplitude, relieving dentin sensitivity, and treating periodontitis

Active Publication Date: 2022-02-11
SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are basically two anti-sensitivity mechanisms: (1) adding strontium acetate to the toothpaste, the strontium acetate contained in the toothpaste is similar to fine particles to close the dentinal tubules, weakening or even preventing the flow of liquid in the dentinal tubules Relieve tooth sensitivity; use filling materials, such as resin, which can cover and block dentin tubules. Filling treatment has a good immediate and long-term effect on DH caused by severe abrasion, but this method needs to grind away part of the healthy dentin
(2) There are also some anti-sensitivity toothpastes containing potassium ions, which work by hindering the mechanism of nerve signal transmission, that is, reducing the sensitivity of the dental nerve and making it less sensitive to stimulation

Method used

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  • Application of a kind of glycerol glucoside in the preparation of oral care products
  • Application of a kind of glycerol glucoside in the preparation of oral care products
  • Application of a kind of glycerol glucoside in the preparation of oral care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Press 4×10 4 Gingival fibroblasts were seeded into 24-well culture plates at a seeding density of cells / well and placed in an incubator (37°C, 5% CO 2 ) and incubated overnight.

[0040] (2) Configure the working solution of the test substance according to Table 1 of the experimental design table, the solvent is the medium, and the NC group is the negative control group (without adding drugs), the concentration of dexamethasone in the PC group is 100 μg / mL, and The concentration of 2-αGG in the medium was 0.625%, and the induction condition was IL-1α (1ng / mL).

[0041] Table 1. Experimental design table

[0042]

[0043](3) When the cell plating rate in the 24-well plate reaches 40%~50%, according to the groups in the experimental design in Table 1, add the above-mentioned different working solutions of the test substances into the well plate for group administration and stimulation, The dosage in each well was 1 mL, and three replicate wells were set up in ea...

Embodiment 2

[0056] Electrophysiological experiments on neonatal rat dorsal root ganglion (DRG) neurons by whole-cell patch clamp:

[0057] DRG neuron isolation

[0058] 1) Take out SD rats within 24 hours, put them on ice for anesthesia, cut off the back skin, take out the spine, put it in pre-cooled HBSS, remove the blood and spinal cord, and fully expose the DRG;

[0059] 2) Remove the DRG with tweezers under a dissecting microscope and put it into pre-cooled HBSS. After removing all the DRG, cut off the nerves on the DRG with tweezers;

[0060] 3) Put all the nerve-removed DRG tissues into a centrifuge tube filled with HBSS, and transfer to the intercellular space;

[0061] 4) Centrifuge at 900r / min for 3min to remove HBSS;

[0062] 5) Add digestive solution, digest at 37°C for 45 minutes;

[0063] 6) Remove the digestive juice, add more than a dozen drops of FBS, stop the action of the digestive juice, centrifuge at 900r / min for 3min, and remove the FBS;

[0064] 7) Add 1mL NB med...

Embodiment 3

[0080] In terms of mass percentage, 1% glycerol glucoside, 0.005% disodium hydrogen phosphate, 0.002% sucralose, and 98.993% pure water were uniformly mixed to prepare oral soothing spray.

[0081] Recruit 60 subjects with oral inflammation or tooth sensitivity to conduct a consumer trial survey, 30 people as a group, a group of volunteers use oral soothing spray containing 2-αGG, and a group of volunteers use oral spray without 2-αGG Spray, use the product continuously for 28 days, and conduct a scoring test.

[0082] Scoring value out of 5 points, of which,

[0083] 5 points: The redness and swelling of the gums subsided, the oral ulcers improved, and the sensitivity of the teeth was relatively slowed down;

[0084] 4 points: The redness and swelling of the gums has subsided, the oral ulcers have improved to a certain extent, and the sensitivity of the teeth has been alleviated and improved significantly;

[0085] 3 points: The redness and swelling of the gums has subsided...

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PUM

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Abstract

The invention discloses an application of glycerol glucoside in the preparation of oral care products. The stereo configuration of the glycerol glucoside is 2‑αGG. Glycerol glucoside can inhibit the secretion of inflammatory factors such as tumor necrosis factor (TNF-α) and interleukin-8 (IL-8) from gingival fibroblasts; it can significantly reduce the release frequency and amplitude of action potentials in neurons, and has neuronal Sexual antisensitivity effect. Applying the glycerol glucoside to oral care products can treat or relieve periodontitis, relieve dentin sensitivity, and the like.

Description

technical field [0001] The invention relates to the field of oral care products, in particular to the application of glycerol glucoside in the preparation of oral care products. Background technique [0002] Oral diseases are common diseases and frequently-occurring diseases that affect human health. The caries rate of deciduous teeth in children, the caries rate of permanent teeth in middle-aged people, and the proportion of edentulous people in the elderly population are relatively high. The detection rate of gingivitis and tartar in the population is also high, and oral health problems are common. [0003] Periodontitis can activate a variety of target cells in the periodontal tissue to synthesize, secrete various cytokines and inflammatory mediators, and participate in the destruction of periodontal tissue. Gingival fibroblasts are the main cell components in periodontal tissue, which can synthesize and secrete various cytokines and inflammatory mediators, and participa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61Q11/00A61P1/02A61P29/00A61P37/08
CPCA61K8/602A61Q11/00A61P1/02A61P29/00A61P37/08
Inventor 张嘉恒廖雅詹憬博王岩苏晶
Owner SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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