Anisodamine and purification process thereof

Abstract

The invention provides anisodamine and a purification process thereof, and relates to the technical field of medicines. The purification process of anisodamine comprises the following steps: adding a compound enzyme solution with a concentration of 0.05-0.15 wt% into radix physochlainae for enzymolysis treatment, and then filtering and separating to obtain an Anisodus tanguticus extract and primary filtrate; adding ethanol I into the primary filtrate for primary extraction to obtain extract liquid; carrying out reduced pressure distillation on the extract liquid to obtain a crude extract liquid; adding ethanol I into a mixture of the crude extract liquid and the Anisodus tanguticus extract for secondary extraction and filtration to obtain secondary filtrate; and carrying out reduced pressure distillation on the secondary filtrate at the temperature of 50-60 DEG C until no ethanol exists to obtain purified anisodamine. By means of the operation, the anisodamine is purified, and the physiological activity of the anisodamine can be reserved to the maximum extent. On the other hand, the invention also provides the anisodamine which is prepared by the purification process of the anisodamine. The anisodamine is relatively high in purity, relatively excellent in physiological activity and relatively good in stability.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to anisodamine and a purification process thereof. Background technique [0002] Anisodamine is mainly an alkaloid extracted from Tanguthua ginseng, a plant of the Solanaceae family. The natural product is anisodamine hydrobromide, and the synthetic product is called racemic anisodamine, both of which are M choline receptors blocker. It has the functions of relieving vasospasm (especially capillaries), improving microcirculation, relaxing smooth muscle, inhibiting glandular secretion, anti-shock, pupil dilating and analgesia, etc. It is mainly used clinically to relieve visceral smooth muscle spasm, anti-infective shock and sedation. Pain, treatment of vertigo, peripheral vascular disease, fundus disease and sudden deafness. As a national essential drug, anisodamine is still one of the most commonly used drugs in primary medical institutions. In recent years, with the gradual de...

AI Technical Summary

Problems solved by technology

[0003] However, the primary extract of anisodamine often has disadvantages such as low content of active ingredients, many impurities, and unstable quality, resulting in poor absorption and utilization by the human body.

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