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Applin-APJ inhibitor in the application of the application of blood test barrier damage drugs

A barrier damage and treatment drug technology, applied in the field of biomedicine, to prevent damage, ensure integrity, and improve sperm quality

Active Publication Date: 2022-08-05
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Similarly, the level of Apelin in patients with type 1 diabetes will be relatively increased, and this abnormal increase will obviously bring unpredictable risks to human health

Method used

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  • Applin-APJ inhibitor in the application of the application of blood test barrier damage drugs
  • Applin-APJ inhibitor in the application of the application of blood test barrier damage drugs
  • Applin-APJ inhibitor in the application of the application of blood test barrier damage drugs

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Embodiment Construction

[0051] In order to make the invention purpose, technical solutions and technical effects of the present invention clearer, the present invention will be further described in detail below with reference to the specific embodiments. It should be understood that the specific embodiments described in this specification are only for explaining the present invention, rather than for limiting the present invention.

[0052] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial sources.

[0053] Experimental Materials

[0054] The Apelin-APJ inhibitors in the following examples are all selected as ML221.

[0055] ML221, chemical name is 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one, CAS number is 877636-42 -5, the structural formula is shown in formula I.

[0056]

[0057] Of course, the following examples are only represented by ML221, which does not mean th...

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Abstract

The invention discloses the application of Apelin-APJ inhibitor in the treatment of blood-testis barrier damage. The inventors of the present invention found that the use of Apelin-APJ inhibitor can effectively promote the expression of genes related to the blood-testis barrier in cells, ensure the integrity of the blood-testis barrier, increase the blastocyst rate of intracytoplasmic sperm injection in mice, and reduce zygotic embryo arrest, Therefore, it can be used for related problems such as reproductive system damage caused by chronic diseases, and has extremely high application value and clinical significance. Moreover, the Apelin-APJ inhibitor in the present invention has no obvious toxic and side effects within a dosage of 0.1-100 μM, and can be safely used for related purposes such as drug preparation.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of an Apelin-APJ inhibitor in the treatment of blood-testis barrier damage. Background technique [0002] Diabetes mellitus (DM) is a metabolic disorder characterized by insulin secretion deficiency, insulin resistance or both, among which type 2 diabetes is one of the most common chronic diseases in humans. Diabetes suffers from a wide range of people and is dangerous. Type 2 diabetes can cause damage to most of the body's system functions, posing a huge threat to human health. [0003] In the related art, the large logarithmic research only focuses on the pathogenesis of diabetes on the kidney and retina and other important organ damage, but there is little research on the impact of diabetes on the human reproductive system. As studies have found that the age of first diagnosis of type 2 diabetes is decreasing, and it is also found that one of the important complica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K38/10A61K31/506A61P3/10
CPCA61K45/00A61K38/10A61K31/506A61P3/10
Inventor 赵小阳刘昭廷宋可夏馨雨许晓珩
Owner SOUTHERN MEDICAL UNIVERSITY
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