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Composition for improving cerebral neurotrophic function and application thereof

A neurotrophic and composition technology, applied in the fields of application, drug combination, nervous system diseases, etc., can solve the problems of undisclosed asparagus composition application and mechanism of action, wide range of brain functions, etc., to improve the neurotrophic function of the brain, reduce the level, effect of increasing content

Active Publication Date: 2018-10-30
黄云祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent has a wide range of brain functions, and does not disclose the specific application and mechanism of the asparagus composition

Method used

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  • Composition for improving cerebral neurotrophic function and application thereof
  • Composition for improving cerebral neurotrophic function and application thereof
  • Composition for improving cerebral neurotrophic function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The composition for improving the neurotrophic function of the brain, by weight percentage, includes the following components: 95% of asparagus extract, 1.5% of phosphatidylserine, 1.4% of fungal extract, 0.8% of theanine, and γ-aminobutyric acid 1.3%. The improvement of brain neurotrophic function refers to the effect of increasing hippocampal acetylcholine content or promoting the growth of brain-derived neurotrophic factor or promoting nerve growth factor gene expression.

[0039] The preparation method of asparagus extract is as follows: asparagus stems and leaves are dried and crushed, soaked, 40% ethanol aqueous solution is used as the solvent, and normal temperature extraction and ultra-high pressure extraction are used alternately. The number of ultra-high pressure extraction is 2 times, each time The ultra-high pressure extraction time is 2min, the extraction pressure is 200MPa, the material-to-liquid ratio is 1:15, and the total extraction time is 40min. The aspa...

Embodiment 2

[0095] Example 2 is basically the same as Example 1, except that the composition includes the following components by weight percentage: asparagus extract 93.3%, phosphatidylserine 0.9%, fungal extract 2.4%, and theanine 1.6 %, γ-aminobutyric acid 1.8%.

[0096] The preparation method of asparagus extract is as follows: dry and crush the asparagus scraps and soak, use water as the solvent, and use the method of alternating extraction at room temperature and ultra-high pressure. The number of ultra-high-pressure extraction is 3 times, and each ultra-high-pressure extraction time The extraction pressure is 300MPa, the material-to-liquid ratio is 1:20, and the total extraction time is 30min. The asparagus extract is obtained. The asparagus extract is adsorbed by activated carbon. The added amount of activated carbon is 4% of the weight of the extract. The adsorption contact time is 30 minutes, and then it is filtered and purified by an electrode membrane with a thickness of 0.5 mm, ...

Embodiment 3

[0099] Example 3 is basically the same as Example 1, except that: the composition includes the following components by weight percentage: asparagus extract 97%, phosphatidylserine 2.2%, fungal extract 0.3%, and theanine 0.29 %, γ-aminobutyric acid 0.21%.

[0100] The preparation method of asparagus extract is as follows: dry and crush the asparagus scraps and soak, use water as the solvent, and adopt the method of alternating extraction at room temperature and ultra-high pressure. The number of ultra-high-pressure extraction is 4 times, and each ultra-high-pressure extraction time The extraction pressure is 500 MPa, the material-to-liquid ratio is 1:30, and the total extraction time is 60 minutes. The asparagus extract is obtained. The asparagus extract is adsorbed by activated carbon. The addition amount of activated carbon is 6% of the weight of the extract. The adsorption contact time is 15 minutes, and then it is filtered and purified by an electrode membrane with a thickness...

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Abstract

The invention relates to a composition for improving cerebral neurotrophic function. The composition comprises, by weight, 91.1-99.8% of asparagus extract, 0-2.4% of phosphatidylserine, 0-2.4% of fungal extract, 0.09-1.6% of theanine and 0.09-2.0% of gamma-aminobutyric acid. The asparagus extract is solid powder or liquid, and refers to the extract, with asparagus saponin content not less than 0.3g / 100g, extracted from one or multiple of asparagus stems, leaves or leftovers; the fungal extract refers to the extract from one or multiple of shiitake mushroom, glossy ganoderma, hericium erinaceus, pleurotus cornucopiae and pleurotus eryngii; extraction solvents of the asparagus extract and the fungal extract both refer to water or mixture of ethyl alcohol and water. The composition can promote growth of the brain derived neurotrphic factor by increasing content of hippocampus acetyl choline, improve mechanisms such as neurotrophic growth factor gene expression, and play a role in improving the cerebral neurotrophic function.

Description

Technical field [0001] The invention belongs to the technical field of food and medicine, and relates to a composition, particularly a composition for improving brain neurotrophic function and its application. Background technique [0002] As a high-level center that regulates various systems and organs of the body, the brain participates in and regulates neural activities such as learning, memory, language and consciousness. The function of the brain is closely related to human life. Abnormal brain function will have varying degrees of impact on human cognition, emotion, behavior and the function of various organs, and further affect human daily life, work, study and social activities. my country is the world's most populous country, but overall, the population quality is low and the lack of high-quality human resources has become a bottleneck restricting my country's social and economic development. Today’s society emphasizes giving priority to the development of education, bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P25/28A61P25/00A61P9/10A23L33/105A23L33/10A23L33/175A61K31/685A61K31/198A61K31/197
CPCA23V2002/00A61K31/197A61K31/198A61K31/685A61K36/07A61K36/074A61K36/899A61K2236/31A61K2236/331A61K2236/333A61K2236/39A61K2236/51A23L33/10A23L33/105A23L33/175A61P9/10A61P25/00A61P25/28A61K2300/00A23V2200/30A23V2250/21A23V2250/208A23V2200/322
Inventor 黄云祥安静吕伟祖铁红
Owner 黄云祥
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