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Composition for improving brain neurotrophic function and application thereof

A technology of neurotrophic and composition, applied in the directions of application, drug combination, nervous system diseases, etc., can solve the problems of wide range of brain functions, undisclosed application and mechanism of asparagus composition, etc.

Active Publication Date: 2021-04-27
黄云祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent has a wide range of brain functions, and does not disclose the specific application and mechanism of the asparagus composition

Method used

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  • Composition for improving brain neurotrophic function and application thereof
  • Composition for improving brain neurotrophic function and application thereof
  • Composition for improving brain neurotrophic function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]The composition for improving the neurotrophic function of the brain comprises the following components by weight percentage: 95% of asparagus extract, 1.5% of phosphatidylserine, 1.4% of fungal extract, 0.8% of theanine, γ-aminobutyric acid 1.3%. The improvement of brain neurotrophic function refers to increasing the content of acetylcholine in the hippocampus or promoting the growth of brain-derived neurotrophic factor or promoting the expression of nerve growth factor gene.

[0039] Wherein the preparation method of the asparagus extract is as follows: soak asparagus stems and leaves after drying and crushing, use 40% ethanol aqueous solution as solvent, adopt normal temperature leaching and ultra-high pressure extraction to extract alternately successively, and the number of ultra-high pressure extractions is 2 times, each time The ultra-high pressure extraction time is 2min, the extraction pressure is 200MPa, the ratio of solid to liquid is 1:15, and the total extra...

Embodiment 2

[0095] Example 2 is basically the same as Example 1, except that the composition includes the following components by weight percentage: 93.3% of asparagus extract, 0.9% of phosphatidylserine, 2.4% of fungal extract, 1.6% of theanine %, γ-aminobutyric acid 1.8%.

[0096] Wherein the preparation method of the asparagus extract is as follows: soak the asparagus leftovers after drying and crushing, use water as the solvent, adopt normal temperature leaching and ultra-high pressure extraction to alternately extract in sequence, the number of ultra-high pressure extractions is 3 times, and the time for each ultra-high pressure extraction is 3 times. 1min, the extraction pressure is 300MPa, the ratio of solid to liquid is 1:20, and the total extraction time is 30min to obtain the asparagus extract, and the asparagus extract is adsorbed by activated carbon, and the amount of activated carbon added is 4% of the extract weight. The contact time for adsorption is 30 minutes, and then th...

Embodiment 3

[0099] Example 3 is basically the same as Example 1, except that the composition includes the following components by weight percentage: 97% of asparagus extract, 2.2% of phosphatidylserine, 0.3% of fungal extract, and 0.29% of theanine %, γ-aminobutyric acid 0.21%.

[0100] Wherein the preparation method of the asparagus extract is as follows: soak the asparagus leftovers after drying and crushing, use water as the solvent, adopt normal temperature leaching and ultra-high pressure extraction to alternately extract in sequence, the number of ultra-high pressure extractions is 4 times, and the time for each ultra-high pressure extraction is 4 times. 1min, the extraction pressure is 500MPa, the ratio of solid to liquid is 1:30, and the total extraction time is 60min to obtain the asparagus extract, and the asparagus extract is adsorbed by activated carbon, and the addition of activated carbon is 6% of the extract weight. The contact time for adsorption is 15 minutes, and then th...

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Abstract

The present invention relates to a composition for improving the neurotrophic function of the brain, which comprises the following components by weight percentage, asparagus extract 91.9-99.8%, phosphatidylserine 0-2.4%, fungal extract 0-2.4%, theanine Acid 0.09-1.6%, γ-aminobutyric acid 0.09-2.0%, asparagus extract is solid powder or liquid, asparagus extract is asparagus saponin extracted from one or more of asparagus stems, leaves, and leftovers Extracts with a content ≥ 0.3g / 100g, fungal extracts are extracts from one or more of shiitake mushrooms, ganoderma lucidum, Hericium erinaceus, Shiitake mushrooms, and Pleurotus eryngii, and the extraction solvents of asparagus extracts and fungal extracts are all It is a mixture of water or ethanol and water, and the composition can improve brain neurotrophic function through mechanisms such as increasing the content of acetylcholine in the hippocampus, promoting the growth of brain-derived neurotrophic factors, and promoting the expression of nerve growth factor genes.

Description

technical field [0001] The invention belongs to the technical field of food and medicine, and relates to a composition, in particular to a composition for improving the neurotrophic function of the brain and its application. Background technique [0002] As the high-level center that regulates various systems and organs of the body, the brain participates in and regulates neural activities such as learning, memory, language, and consciousness. The function of the brain is closely related to human life, and the abnormality of brain function will have varying degrees of impact on human cognition, emotion, behavior, and the functions of various organs, and further affect human daily life, work, study, and social activities. my country is the most populous country in the world, but overall the quality of the population is low and the lack of high-quality human resources has become a bottleneck restricting my country's social and economic development. Today's society emphasizes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P25/28A61P25/00A61P9/10A23L33/105A23L33/10A23L33/175A61K31/685A61K31/198A61K31/197
CPCA23V2002/00A61K31/197A61K31/198A61K31/685A61K36/07A61K36/074A61K36/899A61K2236/31A61K2236/331A61K2236/333A61K2236/39A61K2236/51A23L33/10A23L33/105A23L33/175A61P9/10A61P25/00A61P25/28A61K2300/00A23V2200/30A23V2250/21A23V2250/208A23V2200/322
Inventor 黄云祥周青安静吕伟祖铁红
Owner 黄云祥
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