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Application of Alfuzosin in preparation of medicine for treating diabetes and complications thereof

A technology of alfuzosin and diabetes, which is applied in the field of new application of alfuzosin in the preparation of drugs for the treatment of diabetes and its complications, can solve the problems of low cure rate of diabetes complications, achieve remarkable therapeutic effect, improve kidney Function, the effect of inhibiting cell death

Active Publication Date: 2021-11-05
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently available hypoglycemic drugs have a low cure rate for diabetic complications, and most patients need life-long medication to control blood sugar

Method used

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  • Application of Alfuzosin in preparation of medicine for treating diabetes and complications thereof
  • Application of Alfuzosin in preparation of medicine for treating diabetes and complications thereof
  • Application of Alfuzosin in preparation of medicine for treating diabetes and complications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Establishing 1 C57BL / 6N mouse diabetic model, and the packet Example

[0047] 1. The establishment of model

[0048] The 70 C57BL / 6N mice were randomly divided into three groups, i.e., normal food group (n = 20), high-fat diet group (n = 20), high-fat diet + STZ group (30).

[0049] Normal diet mice: normal diet after three weeks, 5 days of continuous injection of an equal volume of phosphate buffer solution, and then continue with a normal diet until the end of the modeling;

[0050] High fat diet mice: three weeks after high fat diet, continuous injection of 5 days an equal volume of phosphate buffer solution, and then continue with the high fat diet until the end of the modeling;

[0051] STZ + high-fat diet mice: three weeks after high fat diet, was dosed intraperitoneal injection of STZ 45mg / kg of water fasted 12h (before STZ injection, injection in accordance with the same time period 9:00 am-10:00am after fasted for 2h after injection of STZ finished can be fed...

Embodiment 2

[0062] Example 2 index detection

[0063] The experimental data was statistically analyzed by SPSS23.0 software, and the data was expressed (x ± s), and the inter-group comparison was two-Way ANOVAs and LSD-T method for two comparisons. P <0.05 is considered to have statistical significance.

[0064] 1. body weight and fasting plasma glucose (Fasting Blood Glucose, FBG) monitoring

[0065] Dosing week 0, week fasted After 12h, water the same time period (7:30 pm-9:00pm) fasting blood glucose, blood amount tails, blood glucose content by the glucose meter, the blood glucose level reading recorded ; week before blood glucose measurement electronic weighing scales.

[0066] Effects of alfuzosin results such as fasting blood glucose in diabetic mice figure 1 Shown, wherein Model vs.SD, ### p ** p <0.01, 2 weeks 5 weeks blood glucose increased slightly, from the first six weeks to 12 weeks, Model + Alfuzosin blood glucose groups continued to decline, and lower than the positive control...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a novel purpose of Alfuzosin in preparation of a medicine for treating diabetes and complications thereof. The invention finds that the Alfuzosin participates in a saccharification and oxidation process of an organism, inhibits cell death, enhances the renal function, can effectively reduce the blood sugar of a diabetic model mouse, improves the renal function and reduces cardiovascular and cerebrovascular complication related indexes, including triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and the like, the diabetes and the complications thereof can be effectively prevented or treated, the effect of the Alfuzosin is 165 times of the effect of a clinical medicine metformin, a new choice is provided for the preparation of the medicine for clinical treatment of the diabetes and the complications thereof, and the Alfuzosin has a good clinical application prospect.

Description

Technical field [0001] The present invention belongs to the field of medical technology, in particular to a new use of alfuzosin in the treatment of diabetes and its complications preparation of medicaments. Background technique [0002] Diabetes is a metabolic characterized by hyperglycemia caused by the disease impaired insulin secretion, or biological effects. According to the International Diabetes Federation (IDF) released the latest global diabetes map display by the end of 2017 the number of patients with diabetes worldwide reached 425 million, is expected to 2045, global reach 629 million diabetics worldwide diabetes patients showing a sustained upward trend. The diabetic patient may be age, symptoms and onset of the therapeutic agent into type 1 diabetes and type 2 diabetes types. Type 1 diabetes is insulin dependent diabetes mellitus, autoimmune islet B cells in response to injury, the absolute lack of insulin secretion, mainly in children and adolescents, exogenous ins...

Claims

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Application Information

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IPC IPC(8): A61K31/517A61P3/10A61P13/12A61P9/00A61P9/10A61P3/06A61P25/00A61P17/02A61P1/02A61P29/00
CPCA61K31/517A61P3/10A61P13/12A61P9/00A61P9/10A61P3/06A61P25/00A61P17/02A61P1/02A61P29/00
Inventor 陈新平吴桐雨李纯
Owner LANZHOU UNIVERSITY
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