Photo-cured degradable polyester composite guided bone regeneration membrane
A technology that guides bone regeneration and degrades polyester. It is applied in tissue regeneration, medical science, and prostheses. It can solve the problems of increasing the risk of infection in the surgical area, increasing patient pain and economic burden, and the lack of plasticity of the bone regeneration membrane. Problems, achieve controllable degradation time, improve bone regeneration ability, and have no residual effects in the body
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Embodiment 1
[0033] A photocurable polycaprolactone composite guided bone regeneration film, wherein the mass ratio of magnesium powder and methacrylated polycaprolactone is 1:20, and the photoinitiator is 2,4,6-trimethylbenzyl Ethyl acylphenyl phosphonate, the mass ratio of photoinitiator to biodegradable polyester is 0.1:100, the coating ratio of methacrylated polycaprolactone and collagen is 50mg / cm 2 , The thickness of the polycaprolactone composite guiding bone regeneration membrane is 0.50mm, the surface is dense and non-porous, and the elastic modulus is 241.33±27.01MPa.
[0034] Preparation method see figure 1 , including the following steps:
[0035] ①Heat methacrylylated polycaprolactone to a molten state in a constant temperature water bath at 37°C, add photoinitiator 2,4,6-trimethylbenzoylphenylphosphonic acid ethyl ester, photoinitiator and The mass ratio of the biodegradable polyester is 0.1:100, the oscillator oscillates at a speed of 1000rmp, and the time is 15 minutes; t...
Embodiment 2
[0039] Example 2 Performance Test Method of Photocured Polycaprolactone Composite Guided Bone Regeneration Membrane
[0040] Dimensions: Measured with general measuring tools or special measuring tools, the thickness shall be measured according to the method specified in GB / T 6672-2001.
[0041] Mechanical strength: Measured according to the method specified in GB / T 130221991.
[0042] Electron micrographs of photocured polycaprolactone composite guided bone regeneration membrane figure 2 .
[0043] The thickness of the light-cured polycaprolactone composite guiding bone regeneration film can be adjusted according to the coating film ratio, the thickness is 0.30-0.60mm, and the elastic modulus is 241.33±27.01MPa.
Embodiment 3
[0044] Embodiment 3 Animal experiments
[0045] The sample obtained in Example 1 is used for rat skull defect test
[0046] Six healthy 8-week-old SD rats, male, were randomly divided into 2 groups, 3 in each group. All SD rats were raised in an SPF laboratory, ate normally, drank water freely, and adopted preoperative adaptive feeding.
[0047] After the experimental animals were anesthetized by intravenous injection, they were disinfected, the skin was cut open, and the skull was exposed. A bone defect (6mm in diameter) was prepared on the skull with a bone drill, and the photocured polycaprolactone composite guided bone regeneration film was covered on the bone defect area. (smooth side up, rough side down), moderate shaping, light curing, suturing, disinfection.
[0048] Among the two groups of animals, one group of animals was the experimental group, and the skull defect was covered with light-cured polycaprolactone composite guided bone regeneration membrane, which was...
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