Cream for treating cholestatic liver disease pruritus

Abstract

The invention relates to the field of traditional Chinese medicine preparations, in particular to cream for treating cholestatic liver disease pruritus, which is prepared from the following raw materials in percentage: 8% of glycerol, 7% of petrolatum, 4% of wool fat, 2% of paraffin, 0.02% of vitamin E, 3% of shea butter, 12% of stearyl alcohol, 3% of beewax, 2% of PEG-40, 0.02% of phenoxyethanol, 0.02% of peppermint oil and 51.94% of purified water and 15% of liquid medicine obtained by decocting swertia indica, cape jasmine, rheum officinale, radix sophorae flavescentis, fructus cnidii, cortex dictamni, radix paeoniae rubra, garden balsam stem, cocklebur fruit and liquorice. The traditional Chinese medicine composition is simple and convenient in clinical application, has the effects of dredging gallbladder and vital energy, clearing and eliminating dampness and heat and relieving itching, can regulate liver and gallbladder vital energy, expel toxin, calm blood and qi and remove itching, has a better clinical curative effect in long-term clinical practice observation, has less adverse reaction and higher safety, and has better research and popularization values.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a cream for treating cholestatic liver disease pruritus. Background technique [0002] Pruritus, generally defined as "an unpleasant somatic sensation that induces the desire or reflex to scratch", is a common complication of liver disease, especially in cholestatic liver disease (CLD), among which primary biliary cholangitis ( PBC) is typical. PBC with pruritus as the first symptom is not uncommon in clinical practice, but its degree of harm is often underestimated. It is more common in female patients than in male patients, and the symptoms of pruritus in female patients are more severe than those in male patients. Related, pruritus often affects the quality of life of patients, leading to severe insomnia, fatigue, fatigue, depression and even suicide. For some patients, even if liver failure has not yet occurred, intractable pruritus has become an indi...

AI Technical Summary

Problems solved by technology

[0005] Cholestatic liver disease is a type of abnormal liver function. Common causes include infection (viruses, bacteria, parasites, etc.), drug damage, autoimmune diseases, alcoholism, tumors, and genetic metabolism. Damage factors can lead to the occurrence of IHC, so it is often accompanied by other liver function abnormalities, such as aminotransferase abnormalities, prothrombin time (PT) abnormalities, etc. The impact on patients' medication is mainly manifested in affecting drug absorption, distribution, Metabolism and other links, manifested in the decrease of the internal clearance rate of the liver, the decrease of the protein synthesis function of the liver, the decrease of the number of liver cells or the damage of the function, may lead to the decrease of the metabolism speed and degree of the drug mainly cleared through the liver metabolism, the prolongation of the elimination half-life, and the decrease of the blood drug. The higher the concentration, the higher the adverse reactions. Therefore, the clinical use of drugs in patients with cholestatic liver disease is limited. Patients need to choose appropriate drugs according to the clinical type. Even in the treatment of liver diseases, the combination of two or more anti-inflammatory and liver-protecting drugs is not recommended.

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