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Antifouling zwitterionic hydrogel coating with bacterial responsiveness and preparation method of zwitterionic hydrogel coating

A zwitterionic, responsive technology, applied in coatings, catheters, etc., can solve the problems of low stability and complex preparation process, and achieve the effects of low binding force, simple preparation method and environmental friendliness

Active Publication Date: 2021-10-22
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of complex preparation process and low stability in the prior art, to provide a zwitterionic hydrogel coating with bacterial responsive antifouling and a preparation method thereof, to achieve the following objectives: 1. , Exploration has a certain process, making the preparation process easier and more efficient

Method used

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  • Antifouling zwitterionic hydrogel coating with bacterial responsiveness and preparation method of zwitterionic hydrogel coating
  • Antifouling zwitterionic hydrogel coating with bacterial responsiveness and preparation method of zwitterionic hydrogel coating
  • Antifouling zwitterionic hydrogel coating with bacterial responsiveness and preparation method of zwitterionic hydrogel coating

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preparation example Construction

[0035] A preparation method of a high-strength degradable antibacterial hydrogel, the preparation method comprising the following preparation steps:

[0036] 1) Grafting methacrylamide on hyaluronic acid, wherein the molecular weight of hyaluronic acid is less than 5000, and the grafting rate of hyaluronic acid is 65-75%;

[0037] 2) The polymer substrate is treated with oxygen plasma for 0.5 to 5 minutes, and then soaked in a hydrophobic initiator for 5 to 240 minutes, wherein the polymer substrate is PDMS, and the hydrophobic initiator is benzophenone methanol or isopropanol solution;

[0038] 3) Dissolve the zwitterionic monomer, hyaluronic acid, N,N'-methylenebisacrylamide (MBA) and α-ketoglutaric acid in deionized water and stir evenly to form a mixed solution, wherein the zwitterionic monomer Including one or both of sulfobetaine methyl methacrylate and carboxybetaine methyl methacrylate with a concentration of 0.1-4.0mol / L, and the concentration of hyaluronic acid is re...

Embodiment 1～9

[0043] A preparation method of a high-strength degradable antibacterial hydrogel, the preparation method comprising the following preparation steps:

[0044] 1) Grafting methacrylamide on hyaluronic acid, wherein the molecular weight of hyaluronic acid is less than 5000, and the grafting rate of hyaluronic acid is 70.6%;

[0045] 2) The polymer substrate is treated with oxygen plasma for 2 minutes and then immersed in a hydrophobic initiator for 5 to 240 minutes, wherein the polymer substrate is PDMS, and the hydrophobic initiator is benzophenone methanol solution;

[0046] 3) Dissolve the zwitterionic monomer, hyaluronic acid, N,N'-methylenebisacrylamide (MBA) and α-ketoglutaric acid in deionized water and stir evenly to form a mixed solution, wherein the zwitterionic monomer It is sulfobetaine methyl methacrylate with a concentration of 0.1-4.0mol / L, the concentration of hyaluronic acid is 0.4-0.8mol% relative to the zwitterionic monomer, and N,N'-methylenebisacrylamide The...

Embodiment 1

[0065] Table 3 shows the coefficient of friction of the hydrophobic initiator of the polymer substrate prepared in Example 1 for different immersion times. When the immersion time gradually increased, the mechanical properties of the friction coefficient samples of the hydrogel coating first increased and then decreased. When the immersion time was 5 min, the friction coefficient reached the lowest value of 0.05.

[0066] Table 3 The coefficient of friction of the hydrogel coating prepared in Example 1 in the hydrophobic initiator for different immersion times.

[0067] Soaking time blank 5min 30min 120min 240min coefficient of friction 0.68 0.05 0.46 0.08 0.12

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Abstract

The invention relates to the technical field of polymer hydrogel, in particular to an antifouling zwitterionic hydrogel coating with bacterial responsiveness and a preparation method thereof. The hydrogel coating contains hyaluronic acid, wherein the hydrogel coating is a zwitterionic polymer, and the molecular chain of the polymer has anionic and cationic groups at the same time. The preparation method disclosed by the invention is simple, efficient and environment-friendly; interface interpenetration firm combination is formed between the hydrogel coating and a polymer substrate, a certain binding force and a low friction coefficient are achieved, and the coating is degraded and falls off under the condition that bacteria secrete hyaluronidase, so the effect of resisting bacterial adhesion is achieved; and the antifouling zwitterionic hydrogel coating can be stored in deionized water for a long time, has excellent hydrophilicity, bending resistance and friction resistance, and has wide application prospects in the field of biomedical surface materials, especially in the aspect of serving as a medical catheter surface coating and the like.

Description

technical field [0001] The invention relates to the technical field of polymer hydrogel, in particular to a zwitterionic hydrogel coating with bacteria responsive antifouling and a preparation method thereof. Background technique [0002] In the field of biomedicine, biological contamination can easily occur on devices such as sensors, interventional catheters, or bone materials, leading to inflammatory reactions and rejection reactions. At the same time, due to the wide range of applications of medical equipment, they are often located in complex environments such as blood and body fluids. The biocontamination formed in this field is mainly thrombus and bacterial film formation, which poses a great threat to the life safety of patients. The development process of biological pollution is firstly that protein is adsorbed on the surface of the material to form a protein layer, and then the adhesion of bacteria, blood cells, etc. is triggered, which eventually leads to bacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61L29/16C08F285/00C08F220/38C08F222/38C08F2/48
CPCA61L29/085A61L29/145A61L29/16A61L29/14C08F285/00C08F2/48A61L2300/236A61L2300/404A61L2300/606C08L51/02C08F220/387C08F222/385C08F2500/26
Inventor 张静吴敏敏彭湃罗鑫鑫
Owner ZHEJIANG UNIV OF TECH
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