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Physical and chemical dual-network hydrogel for subcutaneous filler as well as preparation method and application thereof

A hydrogel and filler technology, applied in the field of physical and chemical double network hydrogel for dermal fillers and its preparation, can solve the problems of skin inflammation and achieve good tissue adhesion and anti-degradation characteristics , Improve the effect of action time

Pending Publication Date: 2021-10-15
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hyaluronic acid hydrogel fillers have been widely used in the field of medical aesthetics, the residual cross-linking agent in the chemical gel can easily cause skin inflammation

Method used

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  • Physical and chemical dual-network hydrogel for subcutaneous filler as well as preparation method and application thereof
  • Physical and chemical dual-network hydrogel for subcutaneous filler as well as preparation method and application thereof
  • Physical and chemical dual-network hydrogel for subcutaneous filler as well as preparation method and application thereof

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preparation example Construction

[0033] A preparation method of physical and chemical double network hydrogel for dermal filler, the method comprises the following steps:

[0034] (1) Dissolve hyaluronic acid in deionized water to form a clear and transparent hyaluronic acid solution, and then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) Add N-hydroxysuccinimide (NHS) into the hyaluronic acid solution and stir, then add furfurylamine, after the reaction, dialyze and freeze-dry the above solution to obtain furfurylamine-modified hyaluronic acid; wherein, hyaluronic acid The acid is obtained by biological fermentation or extracted from animal tissues such as cockscombs; the molecular weight of the hyaluronic acid is 5-2000kDa, and the mass concentration of the hyaluronic acid solution is 0.5-10%. The molar ratio between furfurylamine and the repeating unit of hyaluronic acid is (0.05-1):1; the sum of the mass of the catalyst EDC and NHS is 10-100% of the mass of hyaluronic acid;

[003...

Embodiment 1

[0041] Step 1: First dissolve hyaluronic acid (5g) in deionized water (500mL) to form a clear and transparent hyaluronic acid solution, then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride (EDC, 1.0g) and N-hydroxysuccinimide (NHS, 0.5g) were added to the above hyaluronic acid solution and stirred for a certain period of time, then furfurylamine (0.5g) was added and reacted for 24 hours, Dialysis and freeze-drying the above solution to obtain furfurylamine-modified hyaluronic acid;

[0042] Step 2: Dissolve the furfurylamine-modified hyaluronic acid obtained in step 1 in deionized water to form a furfurylamine-modified hyaluronic acid solution (1%), then adjust the pH of the solution to acidic (pH=1.5), and then Add maleimide-modified polyethylene glycol (MAL-PEG, 0.5 g) as a cross-linking agent to the above acidic mixed solution. The obtained acidic mixed solution was divided into containers and sealed and frozen for 72 hours, then the container was taken out...

Embodiment 2

[0046] Step 1: First dissolve hyaluronic acid (5g) in deionized water (500mL) to form a clear and transparent hyaluronic acid solution, then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride (EDC, 2.0g) and N-hydroxysuccinimide (NHS, 1.0g) were added to the above hyaluronic acid solution and stirred for a certain period of time, then furfurylamine (1.0g) was added and reacted for 24 hours, Dialysis and freeze-drying the above solution to obtain furfurylamine-modified hyaluronic acid;

[0047] Step 2: Dissolve the furfurylamine-modified hyaluronic acid obtained in step 1 in deionized water to form a furfurylamine-modified hyaluronic acid solution (1%), then adjust the pH of the solution to acidic (pH=1.5), and then Add maleimide-modified polyethylene glycol (MAL-PEG, 1.0 g) as a cross-linking agent to the above acidic mixed solution. The obtained acidic mixed solution was divided into containers and sealed and frozen for 72 hours, then the container was taken out...

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Abstract

The invention relates to a physical and chemical dual-network hydrogel for a subcutaneous filler and a preparation method and application thereof, and the preparation method comprises the following steps: firstly, carrying out furfuryl amination modification on hyaluronic acid, and then carrying out freezing and unfreezing treatment on a modified hyaluronic acid solution added with a cross-linking agent; finally, obtaining chemically-crosslinked and physically-crosslinked hyaluronic acid double-network hydrogel, and then placing thechemically-crosslinked and physically-crosslinked hyaluronic acid double-network hydrogel in a dialysis bag to be dialyzed until the pH of the hyaluronic acid double-network hydrogel is neutral, wherein the obtained gel is finally used as the subcutaneous filling agent. Compared with the prior art, the hyaluronic acid dual-network hydrogel prepared by using a freeze-thaw physical crosslinking method and a click chemical covalent crosslinking method has good biocompatibility, mechanical properties, hyaluronidase degradation resistance and long-acting subcutaneous filling and forming effects, and can be used as a subcutaneous filling agent in the field of medical beauty.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a physical and chemical double network hydrogel for dermal fillers, a preparation method and application thereof. Background technique [0002] The demand for minimally invasive procedures in aesthetic medicine has grown exponentially over the past few decades. Intradermal fillers have become the most common alternative to soft tissue augmentation plastic surgery. Fillers are injected into the skin to replace missing skin volume or to increase existing skin volume. Fillers are less invasive than implanted devices and provide immediate results, so injecting them has a more natural feel. [0003] However, the biggest disadvantage of injectable fillers is that their effects are usually temporary. Therefore, ideally, the requirements for fillers in the field of medical aesthetics and plastic surgery are mainly safety (i.e., biocompatibility, non-immunogenicity), effectiveness (...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/20A61L27/18A61L27/54C08J3/075C08J3/24C08B37/08C08L5/08C08L71/02
CPCC08J3/075C08J3/246C08B37/0072A61L27/52A61L27/20A61L27/54A61L27/18C08J2305/08C08J2471/02C08L5/08C08L71/02
Inventor 张洪斌蔡志祥
Owner SHANGHAI JIAO TONG UNIV
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