Dry-type gel patch for oral precancerous lesion photodynamic therapy and preparation method thereof

A photodynamic therapy, oral cancer technology, applied in the field of biomedical materials, can solve the problems of increasing patient discomfort and psychological burden, stimulating saliva secretion, increasing the difficulty of doctors, etc., to avoid phototoxicity, patient-friendly, and precise control effect of dose

Active Publication Date: 2021-09-03
陶安琪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical practice, this photosensitizer administration method will still be affected by factors such as saliva secretion and tongue movement, which increases the difficulty of the doctor's operation.
And long-term gauze fixation not only increases the patient's discomfort and psychological burden, but also stimulates saliva secretion, dilutes the photosensitizer, and ultimately affects the therapeutic effect

Method used

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  • Dry-type gel patch for oral precancerous lesion photodynamic therapy and preparation method thereof
  • Dry-type gel patch for oral precancerous lesion photodynamic therapy and preparation method thereof
  • Dry-type gel patch for oral precancerous lesion photodynamic therapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of polyacrylic acid / chitosan dry gel patch:

[0037] (1) Dissolve 3 grams of acrylic acid (AA) in 10 milliliters of water to obtain an aqueous solution of acrylic acid. 1.5 g of chitosan was added into the aqueous acrylic acid solution and stirred at 500 rpm for 30 minutes to obtain solution A.

[0038] (2) Under the condition of avoiding light, bubble the solution A with nitrogen gas for 30 minutes to remove oxygen, add 0.02 g of ammonium persulfate (APS) and 0.01 g of NN-methylenebisacrylamide (BIS), stir well and add In a cylindrical mold with a height of 2 cm and a height of 5 cm, the polyacrylic acid / chitosan double network hydrogel was obtained by polymerization at 60° C. for 2 hours under the protection of nitrogen in the dark.

[0039](3) The polyacrylic acid / chitosan double-network hydrogel prepared in step (2) was dried at 50 degrees Celsius for 6 hours, and sliced ​​into slices with a thickness of 0.5 mm, 1 mm, and 2 mm using a microtome. A poly...

Embodiment 2

[0041] Preparation of polyacrylic acid / chitosan dry gel patch loaded with 5-aminolevulinic acid:

[0042] (1) Dissolve 3 grams of acrylic acid (AA) in 10 milliliters of water to obtain an aqueous solution of acrylic acid. Add 1.5 grams of chitosan (medium viscosity, 200-400 mPa.s) into the acrylic acid aqueous solution, and stir at 500 rpm for 30 minutes to obtain solution A.

[0043] (2) Under the condition of avoiding light, the solution A was bubbled with nitrogen for 30 minutes to deoxygenate, and 0.02 grams of ammonium persulfate (APS), 0.01 grams of NN-methylenebisacrylamide (BIS) and 0.4 grams of 5-amino Levulinic acid, stirred evenly, was added to a cylindrical mold with a diameter of 2 cm and a height of 5 cm, protected from light, and polymerized at 60°C for 2 hours under the protection of nitrogen to obtain a polyacrylic acid / chitosan bismuth loaded with 5-aminolevulinic acid. Network hydrogel.

[0044] (3) The polyacrylic acid / chitosan double-network hydrogel loa...

Embodiment 3

[0047] Preparation of polyacrylic acid / quaternized chitosan dry gel patch loaded with 5-aminolevulinic acid:

[0048] (1) Dissolve 3 grams of acrylic acid (AA) in 10 milliliters of water to obtain an aqueous solution of acrylic acid. Add 1.5 g of quaternized chitosan into an aqueous acrylic acid solution, and stir at 500 rpm for 30 minutes to obtain solution A.

[0049] (2) Under the condition of avoiding light, nitrogen bubbles in solution A for 30 minutes to deoxygenate, add 0.02 g of ammonium persulfate (APS), 0.01 g of NN-methylenebisacrylamide (BIS) and 0.4 g of 5-aminoketone Valeric acid, stirred evenly, added to a cylindrical mold with a diameter of 2 cm and a height of 5 cm, protected from light, and polymerized at 60°C for 2 hours under the protection of nitrogen to obtain polyacrylic acid / quaternized chitosan loaded with 5-aminolevulinic acid Sugar double network hydrogel.

[0050] (3) The polyacrylic acid / quaternized chitosan double-network hydrogel loaded with 5-...

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Abstract

The invention discloses a dry-type gel patch for oral precancerous lesion photodynamic therapy and a preparation method thereof. The dry-type gel patch comprises polyacrylic acid, a chitosan cationic polymer and a photosensitizer, and the polyacrylic acid and the chitosan cationic polymer form double-network gel through chemical crosslinking and electrostatic interaction; and the photosensitizer is dispersed in the dry-type gel patch. The dry-type gel patch prepared by the method is simple in preparation method, and the dry-type gel patch can be obtained through the steps of polymerization, drying and slicing. The diffusion amount and the diffusion proportion of the photosensitizer in the dry-type gel patch to precancerous lesions in an oral cavity are regulated and controlled by the thickness of the dry-type gel patch, the dosage can be accurately controlled, and phototoxicity is avoided.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a dry gel patch for photodynamic therapy of oral precancerous lesions and a preparation method thereof. Background technique [0002] The occurrence and progression of oral cancer is a multi-factor, multi-stage, and deep-seated evolutionary process. The study of the occurrence and outcome of oral cancer from the perspective of oral precancerous lesions has been more and more widely recognized. In 2012 alone, the number of lip and oral cancer cases worldwide exceeded 300,000, and the number of deaths reached 145,000. However, there is no effective treatment for precancerous lesions of the oral cavity. Even with surgical resection, there is still a high recurrence rate, and it will affect the patient's chewing, pronunciation, swallowing and other functions. [0003] Photodynamic therapy is an emerging method for the treatment of oral precancerous lesions. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/70A61K47/36A61K47/32A61P1/02A61P35/00
CPCA61K9/7061A61K9/006A61K47/36A61K41/0061A61K41/0076A61K41/0057A61P35/00A61P1/02
Inventor 王兴袁作楹黄建永陶安琪刘宏伟韩莹
Owner 陶安琪
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