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Biliary stent with nano structure

A nanostructure, biliary technology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve problems such as stent blockage

Active Publication Date: 2021-08-24
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, biliary stents have been widely used in the treatment of biliary stricture and biliary obstruction and can effectively relieve the pain of patients. However, stent blockage caused by postoperative biliary sludge is still a major problem

Method used

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  • Biliary stent with nano structure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A. Determine the nanoimprint template: use silicon dioxide as a template, form a circular hole with a radius of 200nm and a depth of 200nm on the surface of the template by electron beam lithography, and the distance between adjacent circular holes is 200nm;

[0020] B. Using PET film as the substrate, the substrate has been degreased, cleaned and dried for use. Among them, absolute ethanol is used for degreasing, deionized water is used for cleaning, and drying is carried out under nitrogen atmosphere;

[0021] C. Coating UV-curable acrylic polymer on the surface of the substrate, installing the substrate coated with UV-curable acrylic polymer and the nano-imprint template on the printing disc of the imprinter, and irradiating with ultraviolet light, the power of ultraviolet light The density is 7mW / cm 2 , irradiation time 8min;

[0022] D. Separate the silica template and the PET substrate to obtain the nanostructure on the surface of the PET substrate.

Embodiment 2

[0024] A. Determining the nanoimprint template: using silicon dioxide as a template, form a circular hole with a radius of 150nm and a depth of 200nm on the surface of the template by electron beam lithography, and the distance between adjacent circular holes is 200nm;

[0025] B. Using PET film as the substrate, the substrate has been degreased, cleaned and dried for use. Among them, absolute ethanol is used for degreasing, deionized water is used for cleaning, and drying is carried out under nitrogen atmosphere;

[0026] C. Coating UV-curable acrylic polymer on the surface of the substrate, installing the substrate of UV-curable acrylic polymer and the nano-imprint template on the printing plate of the imprinter, and irradiating with ultraviolet light, the power density of ultraviolet light is 7mW / cm 2 , irradiation time 8min;

[0027] D. Separate the silica template and the PET substrate to obtain the nanostructure on the surface of the PET substrate.

Embodiment 3

[0029] A. Determine the nanoimprint template: use silicon dioxide as a template, form a circular hole with a radius of 100nm and a depth of 200nm on the surface of the template by electron beam lithography, and the distance between adjacent circular holes is 200nm;

[0030] B. Using PET film as the substrate, the substrate has been degreased, cleaned and dried for use. Among them, absolute ethanol is used for degreasing, deionized water is used for cleaning, and drying is carried out under nitrogen atmosphere;

[0031] C. Coating UV-curable acrylic polymer on the surface of the substrate, installing the substrate coated with UV-curable acrylic polymer and the nano-imprint template on the printing disc of the imprinter, and irradiating with ultraviolet light, the power of ultraviolet light The density is 7mW / cm 2 , irradiation time 8min;

[0032] D. Separate the silica template and the PET substrate to obtain the nanostructure on the surface of the PET substrate.

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Abstract

According to a biliary stent with a nano structure, nano-scale micro protrusions are formed on the surface of the biliary stent, and equivalently, hydrophilic modification is conducted on the inner surface of the biliary stent. When bile flows through, the nano micro-bulge structures can form a layer of super-hydrophilic and oleophobic water film, so that the adhesion of sludge such as protein, calcium bilirubin and cholesterol crystals in the bile is effectively prevented, and the anti-blocking performance of a biliary stent catheter is improved. Researches show that when the diameter of the nano micro-bulges is 200 nm, the adhesion amount of bile sludge can be reduced to the optimal level.

Description

technical field [0001] The invention relates to the field of nanostructure materials, in particular to a biliary stent with a nanostructure. Background technique [0002] Malignant obstructive jaundice is mostly caused by cholangiocarcinoma, gallbladder cancer, pancreatic cancer, hilar lymph node metastasis of gastrointestinal tumors, and liver cancer that affect the passage of bile excretion into the small intestine. A large amount of intrahepatic cholestasis can cause severe liver dysfunction and decreased digestion and absorption function. If the obstruction lasts for a long time, coagulation dysfunction, liver cell damage, and immune function impairment will occur. If the obstruction is not relieved in time, the patient may be endangered. life. [0003] The best way to relieve biliary obstruction is to place a biliary stent so that bile can flow to the intestinal lumen through the stent. In order to enhance the drainage effect and achieve the purpose of treating the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/10A61L31/14B82Y30/00B82Y40/00
CPCA61L31/06A61L31/10A61L31/14A61L2400/12B82Y30/00B82Y40/00C08L67/02C08L33/02
Inventor 朱帅孙婧张韬
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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