A kind of compound electrolyte injection and preparation method thereof
A technology for compound electrolytes and injections, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and devices for making medicines into special physical or taking forms, etc. and other problems, to achieve the effects of high storage stability, reduced impurity content, and high promotion value
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Embodiment 1
[0029] This embodiment provides a kind of compound electrolyte injection (II), and the prescription dosage is shown in the following table:
[0030]
[0031] Water for injection to 1L.
[0032] The preparation method of above-mentioned compound electrolyte injection (II) is as follows:
[0033] Step a, add 700mL of fresh water for injection into the preparation tank, add the prescribed amount of L-malic acid, magnesium chloride, sodium chloride, potassium chloride, calcium chloride, sodium acetate and sodium hydroxide aqueous solution in sequence, and stir to dissolve , heated to boiling, and kept for 15 minutes to obtain a compound electrolyte solution;
[0034] Step b, adding water for injection to the compound electrolyte drug solution to the total amount of preparation, filtering through polyethersulfone folded filter elements with pore diameters of 0.45 μm and 0.2 μm in turn, filling the drug solution into a multi-layer co-extrusion infusion bag, and sealing , steril...
Embodiment 2
[0036] This embodiment provides a kind of compound electrolyte injection (II), and the prescription dosage is shown in the following table:
[0037]
[0038] Water for injection to 1L.
[0039] The preparation method of above-mentioned compound electrolyte injection (II) is as follows:
[0040] Step a, add 750mL of fresh water for injection into the preparation tank, add the prescribed amount of L-malic acid, magnesium chloride, sodium chloride, potassium chloride, calcium chloride, sodium acetate and sodium hydroxide aqueous solution in sequence, and stir to dissolve , heated to boiling, and kept for 10 minutes to obtain a compound electrolyte solution;
[0041] Step b, adding water for injection to the compound electrolyte drug solution to the total amount of preparation, filtering through polyethersulfone folded filter elements with pore diameters of 0.45 μm and 0.2 μm in turn, filling the drug solution into a multi-layer co-extrusion infusion bag, and sealing , steril...
Embodiment 3
[0043] This embodiment provides a kind of compound electrolyte injection (II), and the prescription dosage is shown in the following table:
[0044]
[0045] Water for injection to 1L.
[0046] The preparation method of above-mentioned compound electrolyte injection (II) is as follows:
[0047] Step a, add 800mL of fresh water for injection into the preparation tank, add the prescribed amount of L-malic acid, magnesium chloride, sodium chloride, potassium chloride, calcium chloride, sodium acetate and sodium hydroxide aqueous solution in sequence, and stir to dissolve , heated to boiling, and kept for 20 minutes to obtain a compound electrolyte solution;
[0048]Step b, adding water for injection to the compound electrolyte drug solution to the total amount of preparation, filtering through polyethersulfone folded filter elements with pore diameters of 0.45 μm and 0.2 μm in turn, filling the drug solution into a multi-layer co-extrusion infusion bag, and sealing , sterili...
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