Abdominal wall tissue repair patch and preparation method thereof
A tissue repair and abdominal wall technology, which is applied to the micro-nanofiber-hydrogel three-dimensional interpenetrating network abdominal wall tissue repair patch and its preparation, and the field of abdominal wall tissue repair patch and its preparation, which can solve the problem of insufficient fatigue resistance of hydrogel , unfavorable defect repair, easy tearing off of the hydrogel, etc., to achieve the effect of promoting adhesion infiltration and nutrient transmission, beneficial to tissue regeneration, and high mechanotransduction efficiency
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Embodiment 1
[0044] A method for preparing a micro-nano fiber-hydrogel three-dimensional interpenetrating network abdominal wall tissue repair patch, the specific steps are as follows:
[0045] (1) Use polyester as raw material, dissolve in dichloromethane, prepare a spinning solution with a mass concentration of 10%, and then perform electrospinning, and use a drum with a surface line speed of 5m / s as the electrospinning receiving device , performing electrospinning for a period of time to obtain an insulating layer with an oriented structure;
[0046] (2) Continue electrospinning with the same spinning solution and spinning process parameters as step (1) on the insulating layer, and add hydrogel precursor (gelatin powder) while receiving micro-nano fibers to obtain Composite layer; in the composite layer, the amount of hydrogel precursor added is 100wt% of the micro-nano fiber;
[0047] (3) Submerging the product obtained in step (2) in 0.1wt% 1-(3-dimethylaminopropyl)-3-ethylcarbodiimi...
Embodiment 2
[0050] A method for preparing a micro-nano fiber-hydrogel three-dimensional interpenetrating network abdominal wall tissue repair patch, the specific steps are as follows:
[0051] (1) Use polypropylene as a raw material, dissolve it in N-N dimethyl benzamide to obtain a spinning solution with a mass concentration of 15%, and then perform electrospinning, and use a drum with a surface line speed of 6m / s as the electrospinning A silk receiving device is used to perform electrospinning for a period of time to obtain an insulating layer with an oriented structure;
[0052] (2) Continue electrospinning with the same spinning solution and spinning process parameters as step (1) on the insulating layer, and add hydrogel precursor (chitosan powder) while receiving micro-nano fibers, A composite layer is prepared; in the composite layer, the addition amount of the hydrogel precursor is 200wt% of the micro-nano fiber;
[0053] (3) Submerge the product obtained in step (2) in a glutara...
Embodiment 3
[0056] A method for preparing a micro-nano fiber-hydrogel three-dimensional interpenetrating network abdominal wall tissue repair patch, the specific steps are as follows:
[0057] (1) Take polytetrafluoroethylene as raw material, dissolve in chloroform, and prepare a spinning solution with a mass concentration of 12.5%, then carry out electrospinning, and adopt a drum with a surface line speed of 7m / s as the electrospinning The receiving device performs electrospinning for a period of time to obtain an insulating layer with an oriented structure;
[0058] (2) Continue electrospinning with the same spinning solution and spinning process parameters as step (1) on the insulating layer, and add a hydrogel precursor (sodium alginate powder) while receiving micro-nano fibers, A composite layer is prepared; in the composite layer, the addition amount of the hydrogel precursor is 300wt% of the micro-nano fiber;
[0059] (3) Submerging the product obtained in step (2) in a calcium ch...
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