Microemulsion gel of anti-human papillomavirus(HPV) plant extract and preparation method and application of microemulsion gel

A technology of plant extracts and microemulsion gels, applied in the field of anti-HPV application, microemulsion gels of anti-HPV plant extracts and its preparation, can solve problems such as poor adhesion, achieve low cost and strong patient compliance , the effect of high-efficiency drug delivery

Active Publication Date: 2021-08-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, the nanoscale structure (10-100nm) formed spontaneously by microemulsions is conducive to enhancing cell uptake, but there are problems such as poor adhesion when applied alone on skin and mucosal surfaces

Method used

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  • Microemulsion gel of anti-human papillomavirus(HPV) plant extract and preparation method and application of microemulsion gel
  • Microemulsion gel of anti-human papillomavirus(HPV) plant extract and preparation method and application of microemulsion gel
  • Microemulsion gel of anti-human papillomavirus(HPV) plant extract and preparation method and application of microemulsion gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A kind of microemulsion gel of anti-HPV plant extract, the steps are as follows:

[0049] (1) Weigh Carbomer 934 powder (1g), and swell in 50g purified water for 12h;

[0050] (2) Add borneol (0.5g) to step (1), stir evenly, adjust the pH to 6.5 with triethanolamine to obtain a gel;

[0051] (3) Weigh Curcuma extract (1.5g), Eucalyptus leaf extract (1.5g), Sophora flavescens extract (1.5g), mix well and add Tween 80 (10g), at 25°C, 40rpm Add purified water dropwise until the system changes from cloudy to clear to obtain a microemulsion;

[0052] (4) Mix the gel obtained in step (1) with the microemulsion obtained in step (3) in a mass ratio of 1:3, and stir evenly to obtain final product.

[0053] See Table 1 for the sensory index and stability investigation of the plant extract microemulsion gel prepared in this example.

[0054] Table 1 Comprehensive evaluation of plant extract microemulsion gel sensory index and experimental index

[0055]

[0056] It can be s...

Embodiment 2

[0058] A kind of microemulsion gel of anti-HPV plant extract, the steps are as follows:

[0059] (1) Weigh Carbomer 940 powder (1g), and swell in 50g purified water for 12h;

[0060] (2) Add borneol (1g) to step (1), stir evenly, adjust the pH to 5.5 with triethanolamine to obtain a gel;

[0061] (3) Weigh eucalyptus leaf extract (8g), add Tween 80 (8g), Tween 20 (2g), mix well, add purified water dropwise at 25°C, 60rpm, until the system changes from cloudy to clear get microemulsion;

[0062] (4) Mix the gel in step (1) with the microemulsion in step (3) in a mass ratio of 1:3, and stir evenly to obtain the product.

Embodiment 3

[0064] A kind of microemulsion gel of anti-HPV plant extract, the steps are as follows:

[0065] (1) Weigh Carbomer 941 powder (1.5g) and swell in 50g purified water for 12h;

[0066] (2) Add borneol (1g) to step (1), stir evenly, and adjust the pH to 6.5 with triethanolamine to obtain a gel;

[0067] (3) Weigh Zedoary Curcuma Extract (1.5g) and Herba Bacteria Extract (1.5g), add Span 80 (6g), mix well, add purified water dropwise at 25°C, 60rpm, until the system changes from turbid to To obtain microemulsion for clarification;

[0068] (4) Mix the gel in step (1) with the microemulsion in step (3) in a mass ratio of 1:2, and stir evenly to obtain the product.

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Abstract

The invention discloses microemulsion gel of an anti-human papillomavirus(HPV) plant extract and a preparation method and application of the microemulsion gel. The microemulsion gel comprises a plant extract and auxiliary materials, and the plant extract includes one or more of a rhizoma curcuma extract, a folium eucalypti extract, a radix sophorae flavescentis extract, a fructus cnidii extract, a radix stemonae extract and a cortex phellodendri extract. According to the invention, the natural plant extract not only can serve as a component of a carrier but also can serve as an active ingredient to enhance the medicine efficacy; by taking carbomer as a matrix, a local topical preparation with antibacterial, anti-inflammatory and antiviral functions is prepared; and the microemulsion gel used for HPV infection and prevention, bacterial and fungal vaginitis, cervical erosion, and daily care of women's private parts especially can reduce mRNA expression levels of key oncogenes E6 and E7 in Hela cells. The microemulsion gel prepared by the invention has high safety, high stability, convenience in administration and high patient compliance; and the processing technology is simple, cost is low and large-scale production is facilitated.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a microemulsion gel of anti-HPV plant extracts, a preparation method thereof and an anti-HPV application. Background technique [0002] HPV, that is, human papillomavirus, has obvious characteristics of tropism for human skin and mucosal epithelial cells. The pathogenic mechanism of HPV is mainly related to immune escape: the virus integrates into granule molecules in epithelial cells, so that the virus cannot be detected by cells throughout its life cycle. The state of endolytic enzyme dissolution, thereby reducing the immune response of the body; after the HPV virus infects the body, it will also integrate its own genes into the host genes, further evading the monitoring of the immune system. HPV is divided into several subtypes, among which the mucotropic high-risk type is mainly HPV16 / 18, and the expression of related proteins is mainly regulated by E6 and E7 gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/06A61K47/32A61K47/10A61P15/02A61P31/20A61P31/04A61P31/10
CPCA61K36/9066A61K36/61A61K36/489A61K36/234A61K36/904A61K36/756A61K9/06A61K9/0034A61K47/32A61K47/10A61P15/02A61P31/20A61P31/04A61P31/10A61K2300/00
Inventor 李斯文李钰
Owner CHINA PHARM UNIV
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