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Local long-acting drug release system for bone disease treatment, and preparation method and application thereof

A technology for the treatment of drugs and bone diseases, applied in the field of local long-acting drug release system for bone disease treatment and its preparation, can solve the problems that have not been fully developed

Inactive Publication Date: 2021-07-30
中国人民解放军总医院第八医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of these materials in the field of medicine has not been fully developed

Method used

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  • Local long-acting drug release system for bone disease treatment, and preparation method and application thereof
  • Local long-acting drug release system for bone disease treatment, and preparation method and application thereof
  • Local long-acting drug release system for bone disease treatment, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The preparation of embodiment 1 poly(caprolactone-lactide-glycolide) block polymer

[0064] Weigh 0.0147g of cetyl alcohol and 0.8406g of caprolactone into a dry polymerization tube, mix evenly and place under dry conditions (inert gas protection such as nitrogen, argon or humidity lower than 20% dry air atmosphere or vacuum conditions) , add 0.005g of stannous isooctanoate, and then polymerize at 100°C-200°C for 10-50 hours under vacuum conditions (below 150Pa). The obtained product is purified by dissolution-precipitation method (dissolving the polymer in one or several good solvents such as chloroform, dichloromethane, acetone, tetrahydrofuran, etc., and precipitating in poor solvents such as ethanol, ether, or petroleum ether) After that, the prepolymer PCL (M w =20,000), vacuum-dried and set aside.

[0065] Add 1.53g of prepolymer PCL with a number average molecular weight of 20,000, 6.37g of lactide, and 2.33g of glycolide into a dry polymerization tube, and mix...

Embodiment 2

[0068] The preparation of embodiment 2 poly(caprolactone-lactide-glycolide) block polymer

[0069]Weigh 0.0147g of cetyl alcohol and 0.8406g of caprolactone into a dry polymerization tube, mix evenly and place under dry conditions (inert gas protection such as nitrogen, argon or humidity lower than 20% dry air atmosphere or vacuum conditions) , add 0.005g of stannous isooctanoate, and then polymerize at 100°C-200°C for 10-50 hours under vacuum conditions (below 150Pa). The obtained product is purified by dissolution-precipitation method (dissolving the polymer in one or several good solvents such as chloroform, dichloromethane, acetone, tetrahydrofuran, etc., and precipitating in poor solvents such as ethanol, ether, or petroleum ether) After that, the prepolymer PCL (M w =20,000), vacuum-dried and set aside.

[0070] Add 1.53g of prepolymer PCL with a molecular weight of 20,000, 4.69g of lactide, and 3.78g of glycolide into a dry polymerization tube, mix well and then dry i...

Embodiment 3

[0072] The preparation of embodiment 3 poly(caprolactone-lactide-glycolide) block polymer

[0073] Weigh 0.0147g of cetyl alcohol, 0.8406g of caprolactone, add in the dry polymerization tube, mix well and then in dry conditions (inert gas protection such as nitrogen, argon or humidity is lower than 20% dry air atmosphere or vacuum conditions) 0.005g stannous isooctanoate was added, and then polymerized at 100°C-200°C for 10-50 hours under vacuum conditions (below 150Pa). The obtained product is purified by dissolution-precipitation method (dissolving the polymer in one or several good solvents such as chloroform, dichloromethane, acetone, tetrahydrofuran, etc., and precipitating in poor solvents such as ethanol, ether, or petroleum ether) After that, the prepolymer PCL (M w =20,000), vacuum-dried and set aside.

[0074] Add the prepolymer PCL with a weight-average molecular weight of 20,000, 5.14g lactide, and 1.78g glycolide into the dry polymerization tube, and mix them un...

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Abstract

The invention discloses a local long-acting drug release system for bone disease treatment, and a preparation method and application thereof, and relates to the field of drug release technology development. The drug release system comprises a bone disease treatment drug, a poly(caprolactone-lactide-glycolide) block polymer and an inorganic calcium salt. The defects that an existing drug-loaded implant material is poor in biocompatibility, incapable of being completely degraded, serious in initial drug burst release, short in drug release time and the like are overcome, the drug release speed can be constant, and the release period ranges from 2 weeks to 1 year; and the defects that common drug-loaded bone cement is insensitive in antibacterial spectrum, poor in biocompatibility and non-degradable in material are overcome. An obtained drug-loaded biodegradable polymer / inorganic calcium salt local drug release implant material can be implanted into diseased bone parts in vivo to treat related diseases which have clear focus positions such as bone tuberculosis, bone cancer, brucella infection, osteomyelitis and the like and need long-term local drug application.

Description

technical field [0001] The invention relates to the field of drug release technology development, in particular to a local long-acting drug release system for bone disease treatment and its preparation method and application. Background technique [0002] In recent years, with the impact of changes in people's living and working styles, rest and eating habits, and the environment, the number of bone infection diseases and bone cancer patients such as bone tuberculosis, osteomyelitis, and brucellosis is huge, and some diseases have even shown a significant increase trend. . These diseases have devastating consequences on the bone and have a serious impact on the work and life of many patients. At present, an effective way to kill bacteria or cancer cells that cause bone infection is to increase the local drug concentration in the lesion tissue to exert the effective effect of the drug. For severe patients, surgical removal of the lesion site is also required, and then drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/34A61K47/02A61K31/496A61K31/337A61K31/436A61K31/4965A61P19/08A61P31/06A61P35/00A61P31/04C08G63/08C08G63/78
CPCA61K9/0024A61K47/34A61K47/02A61K31/496A61K31/337A61K31/436A61K31/4965A61P19/08A61P31/06A61P35/00A61P31/04C08G63/08C08G63/78
Inventor 李大伟王星雷震周瑾李春林廖玉辉李钢
Owner 中国人民解放军总医院第八医学中心
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