A kind of preparation method of medical dressing with drug-loading function

Abstract

The invention discloses a medical dressing with a drug-carrying function and a preparation method thereof. The preparation method comprises the following steps: dropping ammonia water into a cetyltrimethylammonium bromide (CTAB) solution, heating and stirring in a water bath. Finally, add tetraethyl orthosilicate (TEOS) and stir at high speed. The turbid liquid was centrifuged in a centrifuge and washed three times with 75% ethanol solution. After centrifugation, dry. Finally, the white solid is mashed and calcined in a muffle furnace. Take out and grind to obtain mesoporous nano-silica (MSN). The silk fibroin (SF) aqueous solution was mixed with acetic acid, followed by the addition of chitosan (CS). SF / CS microspheres were prepared. SF aqueous solution and acetic acid solution were mixed in a certain proportion, MSN was added, and sonicated. Add chitosan and stir. MSN-SF / CS was prepared by electrostatic spraying method, and MSN-SF / CS microspheres were sprayed on the SF / PCL-PVA unidirectional water-conducting film. The formed functional medical dressing can solve the shortcomings of the single-layer nanofiber membrane for poor humidity control around the wound and the insufficient functionality of the unidirectional water-conducting nanofiber membrane, thereby promoting wound healing.

Description

technical field [0001] The invention belongs to the field of biomedical textiles, in particular to a preparation method of a medical dressing with a drug-carrying function. Background technique [0002] For acute wounds, there is a lot of bleeding on the wound surface. Traditional hemostatic dressings cannot stop bleeding quickly and completely. It is necessary to add hemostatic drugs to the dressings to achieve rapid hemostasis. Or when treating chronic wounds, it is necessary to add antibiotics to the dressings to treat inflammation. Therefore, medical dressings need to have certain drug-carrying properties. [0003] Traditional wound dressings such as gauze can protect the wound from mechanical damage and reduce bacterial invasion in the environment, and have good air permeability and moisture permeability, which can be used to treat superficial wounds, but the barrier of traditional dressings such as gauze is The effect is poor, the possibility of bacterial invasion is ...

AI Technical Summary

Problems solved by technology

[0002] For acute wounds, the wound has a lot of bleeding, traditional hemostatic dressings cannot stop bleeding quickly and completely, and it is necessary to add hemostatic drugs to the dressing to achieve rapid hemostasis, or when treating chronic wounds, it is necessary to add antibacterial drugs to the dressing to treat inflammation , so medical dressings need to have a certain drug-loading performance

[0003] Traditional wound dressings, such as gauze, can protect the wound surface from mechanical damage and reduce bacterial invasion in the environment, and have good air permeability and moisture permeability, and can be used to treat superficial wounds, but the barrier of traditional dressings such as gauze The effect is poor, the possibility of bacterial invasion is high, and there is no obvious promotion effect on wound healing

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