Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amoxicillin capsule and preparation method thereof

A technology of amoxicillin capsules and amoxicillin, which is applied in the field of pharmaceutical preparations, can solve the problems of short half-life of amoxicillin and low drug utilization, so as to reduce the incidence of adverse reactions, stabilize blood drug concentration, and reduce peak concentration Effect

Active Publication Date: 2021-07-16
CHINA MEHECO SANYANG PHARMA CO LTD
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the short half-life of amoxicillin in the body and the rapid excretion through the urinary tract, the drug availability is low. The time to peak blood concentration after taking the drug is about 2 hours. Ingestion of drugs can maintain blood drug concentration. Generally, amoxicillin drugs are used frequently. Therefore, how to improve the sustained-release effect of amoxicillin, reduce the number of times of taking drugs, and improve drug utilization has become a problem that needs to be solved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of amoxicillin capsule, its content is sustained-release pellet, sustained-release pellet is made up of the raw material of following percentage by weight: described slow-release pellet is made up of the raw material of following percentage by weight: amoxicillin 86%, Seaweed polysaccharide 2%, ethyl cellulose 1.5% and polyethylene glycol 2.5%, dibutyl phthalate 2%, hypromellose 2.5% and polyvinyl alcohol-polyethylene glycol copolymer 3.5%.

[0030] The preparation method of the amoxicillin capsule of the present invention, the preparation method first adopts the dry granulation method according to the formula to prepare the drug-loaded pellet core, prepare the sustained-release pellet from the pellet core, and finally fill the sustained-release pellet into the capsule to obtain Amoxicillin capsules, wherein the sustained-release pellets are film-controlled pellets, and the specific steps are as follows:

[0031] (1) Preparation of drug-loaded pellet core: take a...

Embodiment 2

[0036] A kind of amoxicillin capsule, its content is sustained-release pellet, and sustained-release pellet is made up of following raw materials and auxiliary materials in percentage by weight: amoxicillin 86%, microcrystalline cellulose 2.5%, acrylic resin 3.5%, phthalic acid Dibutyl 2%, talc 2.6%, propylene glycol alginate 3.4%.

[0037] The preparation method of the amoxicillin capsule of the present invention, the preparation method first adopts the dry granulation method according to the formula to prepare the drug-loaded pellet core, prepare the sustained-release pellet from the pellet core, and finally fill the sustained-release pellet into the capsule to obtain Amoxicillin capsules, wherein the sustained-release pellets are film-controlled pellets, and the specific steps are as follows:

[0038] (1) Preparation of drug-loaded pellet core: take amoxicillin, pulverize through a 60-mesh sieve to obtain amoxicillin fine powder; then uniformly mix the obtained amoxicillin ...

Embodiment 3

[0043] A kind of amoxicillin capsule, its content is sustained-release pellet, and sustained-release pellet is made up of following raw materials and auxiliary materials in percentage by weight: amoxicillin 86%, glyceryl behenate 2.5%, ethyl cellulose 1.5% and Mixture of polyethylene glycol 2.5%, castor oil 1.6%, lactose 2.8%, propylene glycol alginate 3.1%.

[0044] The preparation method of the amoxicillin capsule of the present invention, the preparation method first adopts the dry granulation method according to the formula to prepare the drug-loaded pellet core, prepare the sustained-release pellet from the pellet core, and finally fill the sustained-release pellet into the capsule to obtain Amoxicillin capsules, wherein the sustained-release pellets are film-controlled pellets, and the specific steps are as follows:

[0045] (1) Preparation of drug-loaded pellet core: Weigh amoxicillin and glyceryl behenate and pulverize through a 60-mesh sieve to obtain fine powder of a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an amoxicillin capsule and a preparation method thereof, the content of the amoxicillin capsule is a sustained-release pellet, and the sustained-release pellet is composed of the following raw and auxiliary materials by weight: 80%-95% of amoxicillin, 0-5% of a molding material, 2-15% of a sustained-release coating material, 0.5-3% of a plasticizer, 1-6% of an anti-sticking agent and 2-5% of a pore-foaming agent. According to the present invention, the sustained and controlled release effect is good, the bioavailability is high, such that the stable blood concentration is maintained, the medication frequency is reduced, the raw materials are easily available, the preparation process is simple and feasible, the yield is high, the cost is low, the industrial large-scale production can be achieved, and the significant economic benefits are provided.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an amoxicillin capsule and a preparation method thereof. Background technique [0002] Amoxicillin is suitable for upper respiratory tract infections such as otitis media, sinusitis, pharyngitis, tonsillitis, etc. bacteria, Proteus mirabilis or Enterococcus faecalis, acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococcus, Streptococcus pneumoniae, staphylococcus or Haemophilus influenzae, acute simple gonorrhea, etc. It has a good antibacterial effect on severe infections of the upper and lower respiratory tracts. Its preparations include capsules, tablets, granules, dispersible tablets and the like. [0003] Due to the short half-life of amoxicillin in the body and the rapid excretion through the urinary tract, the drug availability is low. Ingestion of drugs can maintain blood drug concentration, and the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/52A61K31/43A61K47/38A61K47/36A61K47/10A61K47/32A61P31/04
CPCA61K9/5047A61K9/5031A61K9/5036A61K9/5026A61K9/5089A61K31/43A61P31/04Y02A50/30
Inventor 陈海刚王玉娟陈晞罗秀莲高嘉璐姚清梅
Owner CHINA MEHECO SANYANG PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com