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Preparation method of nano-silver/diatomite/calcium alginate composite antibacterial hydrogel microspheres

A hydrogel microsphere and composite antibacterial technology, applied in the field of materials, can solve the problems of easy degradation by bacteria, high production cost, toxicity, etc., achieve good antibacterial effect and enhance the effect of mechanical properties

Pending Publication Date: 2021-07-09
WUHAN INSTITUTE OF TECHNOLOGY
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  • Claims
  • Application Information

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Problems solved by technology

For example, the patent application number 201410215058.8 discloses a nano-silver diatomite and its preparation method, which requires calcination at a high temperature of 600 ° C for 1 hour, which has high production costs and is likely to cause environmental pollution. In addition, the diatomite powder itself is relatively light. , small particle size, complex composition, and difficult to collect when dispersed in water, which affects its wide application in the industrial field
Sodium alginate is a hydrophilic polysaccharide polymer extracted from algae. It is easily soluble in water. It is a polyelectrolyte polymer with high surface charge density. It is biodegradable and has good biocompatibility. Therefore, cross-linking with calcium and iron ions is often used as a drug carrier for drug delivery systems, but it has its own limitations of natural gels, such as poor mechanical stability, easy to absorb water and burst
The patents with application numbers 201610103329.X and 202010184751.9, by compounding attapulgite, iron carbon-medicine stone and sodium alginate, enhanced the cross-linking density inside the microspheres and improved the gel strength of the composite microspheres. However, such Hydrogels have weak anti-fouling properties and are easily degraded by bacteria
[0005] In addition, in practical applications, nano-silver particles with high-efficiency and broad-spectrum antibacterial effects are small, easy to agglomerate, difficult to recycle, and easy to cause secondary pollution
In addition, the rapid release of silver ions in nano-silver dissolves in water to a certain concentration, which is potentially toxic.

Method used

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  • Preparation method of nano-silver/diatomite/calcium alginate composite antibacterial hydrogel microspheres
  • Preparation method of nano-silver/diatomite/calcium alginate composite antibacterial hydrogel microspheres
  • Preparation method of nano-silver/diatomite/calcium alginate composite antibacterial hydrogel microspheres

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preparation example Construction

[0031] (2) Preparation of nanosilver loaded on diatomaceous earth: Add silver nitrate (0.1-0.5g) to 10-50ml of absolute ethanol, then use a mechanical stirrer (300rpm) to stir for 2 hours until completely dissolved, add 0.5-3g of silicon Alginate, then ultrasonically disperse for 10-20min, continue to stir for 1 hour to obtain dispersion A, add a certain amount of sodium hydroxide (0.1-0.5g) to the ethanol solution (10-50ml), stir for 1 hour until completely dissolved, Solution B was obtained, and solution B was slowly added to dispersion A, and stirring was continued for 0.5 hours. After the obtained solution is centrifuged-washed-centrifuged, it is dried in a vacuum oven at 30-60° C. for 12 hours to obtain diatomite-based silver nanoparticles.

[0032] (3) Preparation of sodium alginate-embedded nano-silver / diatomite: 0.1-5g of sodium alginate is dissolved in 20-200ml of deionized water, 0.1-5g of diatomite-based nano-silver particles are added, and magnetically stirred for ...

Embodiment 1

[0034] Preparation of nanosilver / diatomaceous earth:

[0035] (1) Purification of natural diatomite: Grind and sieve natural diatomite, take 10g of the powder and add it to hydrochloric acid solution (2mol / L, 500ml) to remove organic and inorganic impurities, then use a magnetic stirrer to continuously stir for 8 hours, and filter through a 400-mesh sieve After netting, the obtained product was washed three times with deionized water, and then dried in an oven at 50 °C.

[0036] (2) Diatomaceous earth-loaded nano-silver: Add silver nitrate (0.2g) to 40 ml of absolute ethanol, then use a mechanical stirrer (200rpm) to stir for 2 hours until completely dissolved, add 1g of diatomaceous earth, and then ultrasonically disperse for 20min, Continue stirring for 1 hour to obtain dispersion A, add a certain amount of sodium hydroxide (0.15g) to ethanol solution (20ml), stir for 1 hour until completely dissolved, obtain solution B, slowly add solution B to dispersion A , and continued...

Embodiment 2

[0039] Preparation of calcium alginate hydrogel microspheres: Dissolve 1g of sodium alginate in 100ml of deionized water, add 1g of diatomaceous earth-based nano-silver particles, stir magnetically for 0.5h, use a 10ml syringe, drop it into chlorine at a constant speed Calcium chloride aqueous solution (20mg / L, 100ml), the solidified gel beads were filtered out to obtain calcium alginate hydrogel microspheres, the appearance of which is as follows figure 2 As shown in (A), the particle size of the calcium alginate hydrogel microspheres is 3-5 mm.

[0040] Preparation of nano-silver / diatomaceous earth / calcium alginate composite antibacterial hydrogel microspheres:

[0041] (1) Purification of natural diatomite: Grind and sieve natural diatomite, take 10g of the powder and add it to hydrochloric acid solution (2mol / L, 500ml) to remove organic and inorganic impurities, then use a magnetic stirrer to continuously stir for 8 hours, and filter through a 200-mesh sieve After nettin...

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Abstract

The invention discloses a preparation method of nano-silver / diatomite / calcium alginate composite antibacterial hydrogel microspheres. The preparation method comprises the following steps: purifying natural diatomite; mixing silver nitrate, absolute ethyl alcohol and the obtained diatomite, and performing ultrasonic dispersion to obtain dispersion liquid A; mixing sodium hydroxide and absolute ethyl alcohol to obtain a solution B; slowly adding B into A, conducting uniform stirring and mixing, successively performing centrifuging, washing and centrifuging, and then carrying out drying to obtain diatomite-based nano-silver particles; dissolving sodium alginate in deionized water, adding the obtained diatomite-based nano-silver particles, and conducting uniform stirring and dispersing; and dropwise adding the obtained dispersion liquid into an aqueous solution of calcium chloride at a constant speed, and filtering out cured gel beads to obtain the composite antibacterial hydrogel microspheres. On the basis of having antibacterial effect, the obtained antibacterial microspheres effectively slow down overflow of silver ions, the fillers have good biocompatibility, and the microspheres have high mechanical strength, are beneficial to recycling and provide guarantee for long-acting sterilization of domestic water.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a preparation method of composite antibacterial hydrogel microspheres. Background technique [0002] Today, with the rapid development of society, health is still one of the most concerned topics. However, there are many harmful microorganisms in the nature on which human beings live, which are the main reasons for human beings to suffer from infection and induce diseases. With the rapid growth of economy and population, water bodies are often polluted by medical waste, human and animal feces, and various sewage. These polluted water bodies contain a large number of pathogenic microorganisms. Once the human body ingests or contacts water contaminated by these pathogenic microorganisms during production and labor, its health and safety will be seriously threatened. According to the survey of the World Health Organization (WHO), 80% of human infectious diseases are r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/00C02F1/50A01N25/08A01N25/26A01N59/16A01P1/00A01P3/00
CPCB01J13/02B01J13/0065B01J13/0056C02F1/50A01N25/08A01N25/26A01N59/16
Inventor 沈喜洲赵殿佳沈陟康顺吉方柳亚梁田叶文康纪钢
Owner WUHAN INSTITUTE OF TECHNOLOGY
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