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Oxidized sodium alginate modified natamycin eye drops and preparation method thereof

A technology for oxidizing sodium alginate and natamycin, which is applied in the field of medical materials, can solve the problems of low degradation rate and achieve the effects of easy storage, low cost, and improved water solubility and permeability

Pending Publication Date: 2021-07-09
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of alginate itself is very low. In order to improve the degradation performance of sodium alginate, sodium alginate is oxidized to convert the hydroxyl group of the uronic acid unit of sodium alginate into an aldehyde group, so as to improve the degradation performance of sodium alginate. purpose; due to the relatively high reactivity of the aldehyde group, it can be coupled with biologically active substances such as active proteins, polypeptides, and specific amino acid sequences, and can improve the interaction between materials and cells. Therefore, it is necessary to seek to design an oxidized sodium alginate Modified natamycin eye drops and a preparation method thereof, using the oxidized sodium alginate obtained after sodium alginate oxidation to improve natamycin, effectively improving the water solubility and permeability of natamycin, and reducing natamycin Reduce the eye irritation and discomfort of toxin, and improve the treatment effect of fungal keratitis

Method used

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  • Oxidized sodium alginate modified natamycin eye drops and preparation method thereof
  • Oxidized sodium alginate modified natamycin eye drops and preparation method thereof
  • Oxidized sodium alginate modified natamycin eye drops and preparation method thereof

Examples

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Embodiment 1

[0027] This example relates to oxidized sodium alginate modified natamycin eye drops, 1mL sterile deionized water contains 0.5-1.5mg oxidized sodium alginate-natamycin lyophilized powder, the specific preparation process is as follows :

[0028] The first step is to prepare oxidized sodium alginate:

[0029] (1) Weigh 10g of sodium alginate with a precision electronic balance, add 200mL of sterilized deionized water, stir magnetically at room temperature for 3-10 hours to prepare a sodium alginate aqueous solution with a mass concentration of 0.05g / mL, and add 1-10g of high iodine Sodium alginate, after reacting in the dark for 3-9 hours, add 0.260-2.60mL of ethylene glycol, magnetically stir for 0.5 hours, stop the reaction, generate oxidized sodium alginate (OSA) mixture solution, add 400mL of absolute ethanol to precipitate out , and then use a circulating water vacuum pump to filter under reduced pressure to obtain a mixed product containing OSA.

[0030] (2) Dissolve th...

Embodiment 2

[0036] This embodiment relates to the preparation method of natamycin eye drops modified by oxidized sodium alginate, and its specific preparation process is as follows:

[0037] The first step is to prepare oxidized sodium alginate:

[0038] Weigh 10g of sodium alginate with a precision electronic balance, add 200mL of sterilized deionized water, stir magnetically at room temperature for 6 hours to prepare a sodium alginate aqueous solution with a mass concentration of 0.05g / mL, add 5g of sodium periodate, and react in the dark for 6 hours Finally, add 1.430mL of ethylene glycol, magnetically stir for 0.5 hours, terminate the reaction, generate oxidized sodium alginate (OSA) mixture solution, add 400mL of absolute ethanol to precipitate the precipitate, and then use a circulating water vacuum pump to filter under reduced pressure to obtain Mixed product containing OSA.

[0039] The mixed product containing OSA was dissolved in sterilized deionized water, and then dialyzed in...

Embodiment 3

[0044] This embodiment relates to the preparation method of oxidized sodium alginate modified natamycin eye drops, and its specific preparation process is as follows: the first step, prepare oxidized sodium alginate:

[0045] (1) Weigh 10 g of sodium alginate with a precision electronic balance, add 200 mL of sterilized deionized water, stir magnetically at room temperature for 3 hours to prepare an aqueous sodium alginate solution with a mass concentration of 0.05 g / mL, add 1 g of sodium periodate, and avoid After 3 hours of photoreaction, add 0.260mL of ethylene glycol, stir magnetically for 0.5 hours, stop the reaction, generate oxidized sodium alginate (OSA) mixture solution, add 400mL of absolute ethanol to precipitate the precipitate, and then use a circulating water vacuum pump to depressurize Suction filtration to obtain a mixed product containing OSA.

[0046] (2) Dissolve the mixed product containing OSA in sterilized deionized water, then dialyze in sterilized doubl...

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Abstract

The invention relates to the technical field of medical materials, in particular to oxidized sodium alginate modified natamycin eye drops and a preparation method thereof. The oxidized sodium alginate modified natamycin eye drops has the component and content that 1 mL of sterilized deionized water contains 0.5-1.5 mg of oxidized sodium alginate-natamycin freeze-dried powder; the oxidized sodium alginate-natamycin is a product obtained by carrying out a Schiff base reaction on oxidized sodium alginate and natamycin; the preparation method comprises the following specific steps: preparing oxidized sodium alginate solid, preparing oxidized sodium alginate-natamycin medicine powder, and preparing the eye drops. The property of the oxidized sodium alginate is similar to that of a human extracellular matrix, so that the oxidized sodium alginate is good in histocompatibility and can be degraded into non-toxic polysaccharide which does not participate in metabolism; the water solubility and permeability of the natamycin are improved, the eye irritation and discomfort of the natamycin are reduced, and the treatment effect of the fungal keratitis is improved; the preparation process is relatively simple, low in cost and easy to store.

Description

Technical field: [0001] The invention relates to the technical field of medical materials, and relates to a natamycin eye drop modified by oxidized sodium alginate and a preparation method thereof. Natamycin is modified by oxidized sodium alginate to effectively improve the natamycin Water-soluble and penetrating, reduce the eye irritation and discomfort of natamycin, and improve the therapeutic effect of fungal keratitis. [0002] technical background: [0003] Fungal keratitis (FK) is a corneal disease caused by pathogenic fungal infection. my country, as a developing country with industry and agriculture as its main industry, is a high-incidence area of ​​fungal keratitis. Corneal trauma, especially plant trauma during production activities provides opportunities for the occurrence of fungal keratitis. With the continuous expansion of the population and the abuse of antibiotics and hormones, the incidence of fungal keratitis has increased significantly in recent years. Mos...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7048A61K47/36A61P27/02A61P31/10C08B37/04
CPCA61K9/08A61K9/0048A61K31/7048A61K47/36A61P27/02A61P31/10C08B37/0084
Inventor 李翠赵桂秋李道浩尹敏彭旭东车成业杜兆东
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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